InterPAD - DETAILS

melphalan, 148-82-3, Alkeran, Melfalan, L-PAM, Phenylalanine mustard, L-Sarcolysine, L-Phenylalanine mustard, L-Sarcolysin, p-L-Sarcolysin, Levofalan, Levofolan, Levopholan, Melfalano, Melphalanum, L-Sarkolysin, 4-[Bis(2-chloroethyl)amino]-L-phenylalanine, Phenylalanine nitrogen mustard, p-Di-(2-chloroethyl)amino-L-phenylalanine, NCI-C04853, Alanine Nitrogen Mustard, CB 3025, p-Bis(beta-chloroethyl)aminophenylalanine, L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine, 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine, p-N-Bis(2-chloroethyl)amino-L-phenylalanine, 4-(Bis(2-chloroethyl)amino)-L-phenylalanine, 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine, Sarcolycin, l-, Melfalano [INN-Spanish], Melphalanum [INN-Latin], Rcra waste number U150, CB-3025, (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid, SK 15673, SK-15673, NSC-8806, CCRIS 374, Phelinun, CHEBI:28876, HSDB 3234, L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, EINECS 205-726-3, Mephalan, At-290, p-N,N-bis(2-chloroethyl)amino-L-phenylalanine, NSC 241286, UNII-Q41OR9510P, BRN 2816456, DTXSID6020804, L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine, Q41OR9510P, 8057-25-8, CHEMBL852, NSC-241286, Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, L-, DTXCID00804, 3025 C.B., ALKERAN (TN), NIOSH/AY3360000, 3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine, L-phenylalanine mustard (L-PAM), NSC8806, 4-14-00-01689 (Beilstein Handbook Reference), Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, L-, Melphalan [USAN:USP:INN:BAN:JAN], NCGC00090757-02, MELPHALAN (IARC), MELPHALAN [IARC], (2S)-2-azaniumyl-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoate, Melfalano (INN-Spanish), Melphalanum (INN-Latin), p-L-sarcolysine, AY33600000, p-N-Di(chloroethyl)aminophenylalanine, MELPHALAN (MART.), MELPHALAN [MART.], L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, MELPHALAN (EP MONOGRAPH), MELPHALAN [EP MONOGRAPH], MELPHALAN (USP MONOGRAPH), MELPHALAN [USP MONOGRAPH], (S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoic acid, CB 3007, (2s)-2-amino-3-(4-[bis(2-chloroethyl)amino]phenyl)propanoic acid, (2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid, (S)-2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid, Melphalan (USAN:USP:INN:BAN:JAN), CAS-148-82-3, SMR000058720, Mustard, Phenylalanine, RCRA waste no. U150, MFCD00057717, NSC241286, Melphalan, powder, Prestwick_1006, Spectrum_000397, Melphalan USP, 2 mg, MELPHALAN [INN], MELPHALAN [JAN], MELPHALAN [MI], MELPHALAN [HSDB], MELPHALAN [USAN], Spectrum2_000074, Spectrum3_000684, Spectrum4_000882, Spectrum5_001601, MELPHALAN [VANDF], Epitope ID:141802, 4-[Bis-(2-chloroethyl)amino]-L-phenylalanine, MELPHALAN [WHO-DD], SCHEMBL5872, BSPBio_002407, KBioGR_001284, KBioSS_000877, MLS001333666, MLS002153368, BIDD:GT0044, DivK1c_000653, SPECTRUM1500382, SPBio_000287, Melphalan (JP17/USP/INN), GTPL7620, MELPHALAN [ORANGE BOOK], HMS502A15, KBio1_000653, KBio2_000877, KBio2_003445, KBio2_006013, KBio3_001627, L01AA03, L-Sarcolysin Phenylalanine mustard, NINDS_000653, HMS2090B09, HMS2091B16, HMS2235D21, Pharmakon1600-01500382, Tox21_111010, Tox21_202522, BDBM50025837, CCG-39704, DL-442, NSC757098, s8266, AKOS015895374, p-di(chloroethyl)amino-L-phenylalanine, Tox21_111010_1, CS-3120, DB01042, NSC-757098, IDI1_000653, Para-di(2-chloroethyl)aminophenylalanine, SMP2_000174, NCGC00090757-01, NCGC00090757-03, NCGC00090757-04, NCGC00090757-05, NCGC00090757-06, NCGC00260071-01, AS-13314, HY-17575, WR-19813, 4-bis(2-chloroethyl)amino-l-phenylalanine, SBI-0052787.P003, Para-di(2-chloroethyl)amino-L-phenylalanine, NS00068077, 4-[bis(2-chloroethyl)-amino]-L-phenylalanine, 4-[bis(2-chloroethyl)-amino]-l-phenyl-alanine, 4-[bis(2-chloroethyl)amino]-(L)-phenylalanine, C07122, D00369, 3(p-(bis(2-chloroethyl)amino)phenyl)-l-alanine, AB00053282-07, AB00053282-08, AB00053282_09, EN300-7479343, P-DI-(2-CHLOROETHYL)AMINO-L-PHENYLALNINE, A808810, SR-05000001667, Q2298283, SR-05000001667-1, W-108096, BRD-K87827419-001-02-8, L-PHENYLALANINE,4-(BIS(2-CHLOROETHYL)AMINO)-, P-N-BIS(2-CHLOROETHYL)AMINO)PHENYL)-L-ALANINE, 2-amino-3-[4-bis(2-chloroethyl)amino]phenylpropanoic acid, (2S)-2-azanyl-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid, 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid, 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid(L-PAM), 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid (Melphalan), 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid(Melphalan)

Name	Melphalan
PubChem CID	460612
Molecular Weight	305.20g/mol
Synonyms	melphalan, 148-82-3, Alkeran, Melfalan, L-PAM, Phenylalanine mustard, L-Sarcolysine, L-Phenylalanine mustard, L-Sarcolysin, p-L-Sarcolysin, Levofalan, Levofolan, Levopholan, Melfalano, Melphalanum, L-Sarkolysin, 4-[Bis(2-chloroethyl)amino]-L-phenylalanine, Phenylalanine nitrogen mustard, p-Di-(2-chloroethyl)amino-L-phenylalanine, NCI-C04853, Alanine Nitrogen Mustard, CB 3025, p-Bis(beta-chloroethyl)aminophenylalanine, L-3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine, 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine, p-N-Bis(2-chloroethyl)amino-L-phenylalanine, 4-(Bis(2-chloroethyl)amino)-L-phenylalanine, 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine, Sarcolycin, l-, Melfalano [INN-Spanish], Melphalanum [INN-Latin], Rcra waste number U150, CB-3025, (2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid, SK 15673, SK-15673, NSC-8806, CCRIS 374, Phelinun, CHEBI:28876, HSDB 3234, L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-, EINECS 205-726-3, Mephalan, At-290, p-N,N-bis(2-chloroethyl)amino-L-phenylalanine, NSC 241286, UNII-Q41OR9510P, BRN 2816456, DTXSID6020804, L-3-(para-(Bis(2-chloroethyl)amino)phenyl)alanine, Q41OR9510P, 8057-25-8, CHEMBL852, NSC-241286, Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, L-, DTXCID00804, 3025 C.B., ALKERAN (TN), NIOSH/AY3360000, 3-(p-(Bis(2-chloroethyl)amino)phenyl)alanine, L-phenylalanine mustard (L-PAM), NSC8806, 4-14-00-01689 (Beilstein Handbook Reference), Alanine, 3-[p-[bis(2-chloroethyl)amino]phenyl]-, L-, Melphalan [USAN:USP:INN:BAN:JAN], NCGC00090757-02, MELPHALAN (IARC), MELPHALAN [IARC], (2S)-2-azaniumyl-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoate, Melfalano (INN-Spanish), Melphalanum (INN-Latin), p-L-sarcolysine, AY33600000, p-N-Di(chloroethyl)aminophenylalanine, MELPHALAN (MART.), MELPHALAN [MART.], L-Phenylalanine, 4-[bis(2-chloroethyl)amino]-, Alanine, 3-(p-(bis(2-chloroethyl)amino)phenyl)-, MELPHALAN (EP MONOGRAPH), MELPHALAN [EP MONOGRAPH], MELPHALAN (USP MONOGRAPH), MELPHALAN [USP MONOGRAPH], (S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoic acid, CB 3007, (2s)-2-amino-3-(4-[bis(2-chloroethyl)amino]phenyl)propanoic acid, (2S)-2-amino-3-{4-[bis(2-chloroethyl)amino]phenyl}propanoic acid, (S)-2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid, Melphalan (USAN:USP:INN:BAN:JAN), CAS-148-82-3, SMR000058720, Mustard, Phenylalanine, RCRA waste no. U150, MFCD00057717, NSC241286, Melphalan, powder, Prestwick_1006, Spectrum_000397, Melphalan USP, 2 mg, MELPHALAN [INN], MELPHALAN [JAN], MELPHALAN [MI], MELPHALAN [HSDB], MELPHALAN [USAN], Spectrum2_000074, Spectrum3_000684, Spectrum4_000882, Spectrum5_001601, MELPHALAN [VANDF], Epitope ID:141802, 4-[Bis-(2-chloroethyl)amino]-L-phenylalanine, MELPHALAN [WHO-DD], SCHEMBL5872, BSPBio_002407, KBioGR_001284, KBioSS_000877, MLS001333666, MLS002153368, BIDD:GT0044, DivK1c_000653, SPECTRUM1500382, SPBio_000287, Melphalan (JP17/USP/INN), GTPL7620, MELPHALAN [ORANGE BOOK], HMS502A15, KBio1_000653, KBio2_000877, KBio2_003445, KBio2_006013, KBio3_001627, L01AA03, L-Sarcolysin Phenylalanine mustard, NINDS_000653, HMS2090B09, HMS2091B16, HMS2235D21, Pharmakon1600-01500382, Tox21_111010, Tox21_202522, BDBM50025837, CCG-39704, DL-442, NSC757098, s8266, AKOS015895374, p-di(chloroethyl)amino-L-phenylalanine, Tox21_111010_1, CS-3120, DB01042, NSC-757098, IDI1_000653, Para-di(2-chloroethyl)aminophenylalanine, SMP2_000174, NCGC00090757-01, NCGC00090757-03, NCGC00090757-04, NCGC00090757-05, NCGC00090757-06, NCGC00260071-01, AS-13314, HY-17575, WR-19813, 4-bis(2-chloroethyl)amino-l-phenylalanine, SBI-0052787.P003, Para-di(2-chloroethyl)amino-L-phenylalanine, NS00068077, 4-[bis(2-chloroethyl)-amino]-L-phenylalanine, 4-[bis(2-chloroethyl)-amino]-l-phenyl-alanine, 4-[bis(2-chloroethyl)amino]-(L)-phenylalanine, C07122, D00369, 3(p-(bis(2-chloroethyl)amino)phenyl)-l-alanine, AB00053282-07, AB00053282-08, AB00053282_09, EN300-7479343, P-DI-(2-CHLOROETHYL)AMINO-L-PHENYLALNINE, A808810, SR-05000001667, Q2298283, SR-05000001667-1, W-108096, BRD-K87827419-001-02-8, L-PHENYLALANINE,4-(BIS(2-CHLOROETHYL)AMINO)-, P-N-BIS(2-CHLOROETHYL)AMINO)PHENYL)-L-ALANINE, 2-amino-3-[4-bis(2-chloroethyl)amino]phenylpropanoic acid, (2S)-2-azanyl-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid, 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid, 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid(L-PAM), 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid (Melphalan), 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid(Melphalan)
Drug Type	Small molecule
Formula	C₁₃H₁₈Cl₂N₂O₂
SMILES	C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl
InChI	1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
InChIKey	SGDBTWWWUNNDEQ-LBPRGKRZSA-N
CAS Number	148-82-3
ChEMBL ID	CHEMBL852
ChEBI ID	CHEBI:28876
TTD ID	D00FGO
Drug Bank ID	DB01042
KEGG ID	C07122
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Curcumin, Melphalan
Partner Name	Curcumin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	CASP7	hsa840
	Up-regulation	Expression	CASP9	hsa842
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Expression	TP53	hsa7157
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	MCF-10A	Healthy	Homo sapiens (Human)	CVCL_0598
Result	Curcumin and melphalan cotreatment induces cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells