Pair Name	alpha-Mangostin, Sorafenib
Phytochemical	alpha-Mangostin
Drug	Sorafenib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	These data demonstrate an unanticipated synergy between α-Mangostin and sorafenib, with mechanistic actions that convert a known safe natural product to a candidate combinatorial therapeutic agent.

Pair Name	Amentoflavone, Sorafenib
Phytochemical	Amentoflavone
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Our results demonstrated that amentoflavone significantly enhanced sorafenib-inhibited tumor growth and expression of ERK/AKT phosphorylation and anti-apoptotic proteins compared to single-agent treatment. Additionally, amentoflavone also triggered sorafenib-induced apoptosis through extrinsic and intrinsic apoptotic pathways.

Pair Name	Artesunate, Sorafenib
Phytochemical	Artesunate
Drug	Sorafenib
Disease Info	[ICD-11: XH50P3]	Non‑hodgkin lymphoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑Hodgkin lymphoma cells through inhibition of the STAT3 pathway

Pair Name	Berbamine, Sorafenib
Phytochemical	Berbamine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Targeting Na+/K+-ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma

Pair Name	Bufalin, Fluorouracil
Phytochemical	Bufalin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Bufalin in combination with 5-FU may induce a higher level of apoptosis compared with monotherapy, and the combination mat be a potential therapeutic strategy for the treatment of colorectal cancer.

Pair Name	Cordycepin, Temozolomide
Phytochemical	Cordycepin
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Cordycepin combined with temozolomide may down-regulate MYC through "MicroRNA in cancer, Proteoglycans in cancer, Pathways in cancer and PI3K-AKT signaling pathway", which in turn regulate the expression of MCL1, CTNNB1, MMP9, PDCD4, thus regulating cell proliferation, migration and apoptosis in glioblastoma.

Pair Name	Curcumin, Binimetinib
Phytochemical	Curcumin
Drug	Binimetinib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Our data demonstrates that curcumin exerts significant synergistic anticancer effects on MM cells by inducing ROS and necroptosis when combined with binimetinib. Therefore, a strategy of adding curcumin to conventional anticancer agents holds promise for treating MM.

Pair Name	Curcumin, Paclitaxel
Phytochemical	Curcumin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Curcumin reduces paclitaxel resistance in ovarian carcinoma cells by upregulating SNIP1 and inhibiting NFκB activity

Pair Name	Fisetin, Sorafenib
Phytochemical	Fisetin
Drug	Sorafenib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Fisetin potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells.

Pair Name	Ginsenoside Rg5, Paclitaxel
Phytochemical	Ginsenoside Rg5
Drug	Paclitaxel
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Ginsenoside Rg5 Sensitizes Paclitaxel-Resistant Human Cervical-Adeno-Carcinoma Cells to Paclitaxel-And Enhances the Anticancer Effect of Paclitaxel

Pair Name	Gossypol, Idarubicin
Phytochemical	Gossypol
Drug	Idarubicin
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	These findings suggest that combinatorial therapy with AT-101 and IDA selectively eliminates leukemia stem-like cells both in vitro and in vivo, representing a potent and alternative salvage therapy for the treatment of relapsed and refractory patients with AML.

Pair Name	Gossypol, Imatinib
Phytochemical	Gossypol
Drug	Imatinib
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	These results suggest that (-)gossypol induced apoptosis in K562 cells through a mitochondria pathway and that the combination of imatinib and (-)gossypol might be an effective treatment for CML.

Pair Name	Gossypol, lenalidomide
Phytochemical	Gossypol
Drug	lenalidomide
Disease Info	[ICD-11: 2A82]	Chronic lymphocytic leukemia		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner.

Pair Name	Honokiol, Osimertinib
Phytochemical	Honokiol
Drug	Osimertinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Our findings warrant further study of HNK and its derivatives in overcoming Osim resistance in the clinic.

Pair Name	Kurarinone, TNF-related apoptosis inducing ligand
Phytochemical	Kurarinone
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Kurarinone Synergizes TRAIL-Induced Apoptosis in Gastric Cancer Cells

Pair Name	Nobiletin, Vorinostat
Phytochemical	Nobiletin
Drug	Vorinostat
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	The combination of nobiletin with vorinostat increased histone H3K9 and H3K27 acetylation levels in SCLC mouse tumor tissue and enhanced the expression of the BH3-only proteins BIM and BID. We conclude that nobiletin is a novel natural BH3 mimetic that can cooperate with vorinostat to induce apoptosis and autophagy in SCLC.

Pair Name	Oleuropein, Cisplatin
Phytochemical	Oleuropein
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	These data revealed that oleuropein regulated the expression of the above-mentioned miRNAs in ovarian cancer cells, which potentially resulted in apoptosis induction, cell proliferation inhibition, and cisplatin resistance decline in ovarian cancer cells. To confirm the results of this study, it is suggested that similar experiments be performed in animal models of ovarian cancer.

Pair Name	Oridonin, Venetoclax
Phytochemical	Oridonin
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Oridonin and venetoclax synergistically promote AML cell apoptosis by inhibiting AKT signaling.

Pair Name	OSW-1, Carboplatin
Phytochemical	OSW-1
Drug	Carboplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Our data revealed the mode of action and molecular mechanism underlying the effect of OSW-1 against TNBC, and provided a useful guidance for improving the sensitivity of TNBC cells to conventional chemotherapeutic drugs, which warrants further investigation.

Pair Name	Periplocin, TNF-related apoptosis inducing ligand
Phytochemical	Periplocin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Antitumor Effect of Periplocin in TRAIL-Resistant gastric cancer cells via upregulation of death receptor through activating ERK1/2-EGR1 pathway

Pair Name	Phenethyl isothiocyanate, Gefitinib
Phytochemical	Phenethyl isothiocyanate
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	We explored the prospect of PEITC in improving the efficacy of targeted drug therapy and demonstrated the synergistic effects and underlined mechanisms of PEITC combined with Gefitinib in NSCLC cells treatment. This study provided useful information for developing novel therapy strategies by combination treatment of PEITC with targeted drugs.

Pair Name	Platycodin D, Venetoclax
Phytochemical	Platycodin D
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Platycodin D may be a potent therapeutic candidate for the treatment of AML

Pair Name	Resveratrol, Rapamycin
Phytochemical	Resveratrol
Drug	Rapamycin
Disease Info	[ICD-11: 2D10.1]	Papillary thyroid cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	The present study suggests that the combination of rapamycin and resveratrol may be a promising strategy for the treatment of papillary thyroid cancer.

Pair Name	Shikonin, TNF-related apoptosis inducing ligand
Phytochemical	Shikonin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	The results indicated that shikonin sensitized resistant cancer cells to TRAIL-induced cytotoxicity via the modulation of the JNK, STAT3 and AKT pathways, the downregulation of antiapoptotic proteins and the upregulation of proapoptotic proteins.

Pair Name	Silibinin, Sorafenib
Phytochemical	Silibinin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	These results suggested that silibinin improved the efficacy of sorafenib in HCC therapy, indicating a clinical promising therapeutic strategy for HCC patients.

Pair Name	Silibinin, Trichostatin A
Phytochemical	Silibinin
Drug	Trichostatin A
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Combinations of TSA with silibinin synergistically augmented the cytotoxic effects of the single agent, which was associated with a dramatic increase in p21 (Cdkn1a)

Pair Name	Tetrandrine, Sorafenib
Phytochemical	Tetrandrine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	The antitumour activity of sorafenib plus tetrandrine may be attributed to the induction of the intrinsic apoptosis pathway through ROS/Akt signaling. This finding provides a novel approach that may broaden the clinical application of sorafenib.

Pair Name	Ursolic acid, Sorafenib
Phytochemical	Ursolic acid
Drug	Sorafenib
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	These results suggest that the synergistic antitumor effects of sorafenib combined with ursolic acid may involve the induction of Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis. Our findings may offer a novel effective therapeutic strategy for tumor treatment.

Pair Name	Ursolic acid, Sorafenib
Phytochemical	Ursolic acid
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	The carrier-free US NPs provide new strategies for HCC treatment and new ideas for the development of novel nano-drug delivery systems containing UA and Sora.

Pair Name	Wogonin, Cisplatin
Phytochemical	Wogonin
Drug	Cisplatin
Disease Info	Head and neck cancer
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Wogonin induced selective cell death by targeting the antioxidant defense mechanisms enhanced in the resistant HNC cells and activating cell death pathways involving PUMA and PARP. Hence, wogonin significantly sensitized resistant HNC cells to cisplatin both in vitro and in vivo. Wogonin is a promising anticancer candidate that induces ROS accumulation and selective cytotoxicity in HNC cells and can help to overcome cisplatin-resistance in this cancer.

Pair Name	Amentoflavone, Sorafenib
Phytochemical	Amentoflavone
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Amentoflavone not only reversed sorafenib-induced anti-apoptotic protein levels but also enhanced sorafenib-induced pro-apoptotic protein expression in SK-Hep1R cells. In conclusion, amentoflavone may be used as a sorafenib sensitizer to enhance sorafenib-induced cytotoxicity and trigger sorafenib-induced apoptosis through extrinsic and intrinsic pathways in SK-Hep1R cells.

Pair Name	Artesunate, Venetoclax
Phytochemical	Artesunate
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	We provide a new triple combination for AML treatment by targeting the Noxa/Mcl-1/Bim axis to reverse Mcl-1/p-Chk1 resistance of cytarabine therapy.

Pair Name	Bufalin, Osimertinib
Phytochemical	Bufalin
Drug	Osimertinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Our study suggests that bufalin eliminates resistance to osimertinib by inhibiting Ku70-mediated MCL-1 overexpression, indicating that a combination of osimertinib and bufalin could be an effective additional treatment to overcome acquired resistance to osimertinib in NSCLC cells.

Pair Name	Gossypol, Gemcitabine
Phytochemical	Gossypol
Drug	Gemcitabine
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression

Pair Name	Honokiol, Paclitaxel
Phytochemical	Honokiol
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Synergistic killing effect of paclitaxel and honokiol in non-small cell lung cancer cells through paraptosis induction

Pair Name	Mitocurcumin, Cytarabine
Phytochemical	Mitocurcumin
Drug	Cytarabine
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	The data suggest that MitoC exploits stress-induced leukemic oxidative environment to up-regulate JNK/p38 signaling to lead to apoptosis and can potentially overcome Cytarabine resistance via ROS/p21/CHK1 axis.

Pair Name	Pentosalen, Cisplatin
Phytochemical	Pentosalen
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	We found that the addition of imperatorin significantly reversed the resistance to cisplatin in cisplatin-resistant HCC cells, which was Mcl-1 dependent. In summary, our study revealed that combination with imperatorin could enhance the antitumor activity of cisplatin via targeting Mcl-1 and reverse the resistance to cisplatin in HCC.

Pair Name	Vinpocetine, Sorafenib
Phytochemical	Vinpocetine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Induced myeloid leukemia cell differentiation protein Mcl-1		Expression
Result	Vinpocetine may be a potential candidate for sorafenib sensitization and HCC treatment, and our results may help to elucidate more effective therapeutic options for HCC patients with sorafenib resistance.