InterPAD - DETAILS

167869-21-8, PD98059, PD 98059, 2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one, PD-98059, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD 98,059, 2-(2-amino-3-methoxyphenyl)chromen-4-one, 2'-AMINO-3'-METHOXYFLAVONE, 4H-1-Benzopyran-4-one, 2-(2-Amino-3-methoxyphenyl)-, PD-098059, C16H13NO3, MFCD00671789, SJE1IO5E3I, CHEMBL35482, CHEBI:77954, 2-(2'-amino-3'-methoxyphenyl)oxanaphthalen-4-one, NSC-679828, 2-(2-Amino-3-methoxy-phenyl)-chromen-4-one, SR-01000076097, PD 098059, 2-(2-Amino-3-methoxyphenyl)-chromen-4-one, NSC 679829, Tocris-1213, PD098059, Lopac-P-215, BiomolKI_000001, UNII-SJE1IO5E3I, 2-(2-amino-3-methoxy-phenyl)chromen-4-one, BiomolKI2_000011, PD 98,059, solid, Lopac0_001028, BMK1-B1, BSPBio_000996, KBioGR_000336, KBioSS_000336, MLS006010134, SCHEMBL157826, GTPL5241, 2''-amino-3''-methoxyflavone, BCBcMAP01_000049, KBio2_000336, KBio2_002904, KBio2_005472, KBio3_000671, KBio3_000672, DTXSID40168416, BCPP000123, Bio1_000475, Bio1_000964, Bio1_001453, Bio2_000338, Bio2_000818, GLXC-04689, HMS1362B17, HMS1792B17, HMS1990B17, HMS3229M08, HMS3263M17, HMS3267D03, HMS3403B17, HMS3412O09, HMS3649N14, HMS3654I16, HMS3676O09, BCP02423, EX-A2127, PD 98059 [WHO-DD], Tox21_501028, BDBM50108771, HB2244, NSC679828, s1177, 2-(2-Amino-3-methoxyphenyl)chromone, AKOS015995212, BCP9001060, BP34124, CCG-100605, CS-0169, LP01028, NSC 679828, NSC-679829, SB16629, SDCCGSBI-0051000.P003, IDI1_002093, SMP2_000052, NCGC00015790-01, NCGC00015790-02, NCGC00015790-03, NCGC00015790-04, NCGC00015790-05, NCGC00015790-06, NCGC00015790-07, NCGC00015790-08, NCGC00025045-01, NCGC00025045-02, NCGC00025045-03, NCGC00025045-04, NCGC00025045-05, NCGC00179347-01, NCGC00261713-01, AC-28412, AS-19374, HY-12028, NCI60_028554, SMR001456459, SY052749, EU-0101028, FT-0716482, P-215, SW218254-2, A25454, P-4313, PD 98059 & Z-100, J-505513, SR-01000076097-1, SR-01000076097-3, SR-01000076097-6, 2-(2-amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran, BRD-K62810658-001-05-6, BRD-K62810658-001-06-4, Q27088281, 2-(2-Amino-3-methoxy-phenyl)-chromen-4-one(PD98059), PD 98059 - CAS 167869-21-8, 4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)- & Z-100

No.	Title	Href
1	Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells. J Int Med Res. 2019 Mar;47(3):1288-1297. doi: 10.1177/0300060518822213.	`Click`
2	Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expressionBufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression. Acta Haematol. 2012;128(3):144-50. doi: 10.1159/000339424.	`Click`

No.

Title

Href

Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells. J Int Med Res. 2019 Mar;47(3):1288-1297. doi: 10.1177/0300060518822213.

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Bufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expressionBufalin induces the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression. Acta Haematol. 2012;128(3):144-50. doi: 10.1159/000339424.

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Name	2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
PubChem CID	4713
Molecular Weight	267.28g/mol
Synonyms	167869-21-8, PD98059, PD 98059, 2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one, PD-98059, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD 98,059, 2-(2-amino-3-methoxyphenyl)chromen-4-one, 2'-AMINO-3'-METHOXYFLAVONE, 4H-1-Benzopyran-4-one, 2-(2-Amino-3-methoxyphenyl)-, PD-098059, C16H13NO3, MFCD00671789, SJE1IO5E3I, CHEMBL35482, CHEBI:77954, 2-(2'-amino-3'-methoxyphenyl)oxanaphthalen-4-one, NSC-679828, 2-(2-Amino-3-methoxy-phenyl)-chromen-4-one, SR-01000076097, PD 098059, 2-(2-Amino-3-methoxyphenyl)-chromen-4-one, NSC 679829, Tocris-1213, PD098059, Lopac-P-215, BiomolKI_000001, UNII-SJE1IO5E3I, 2-(2-amino-3-methoxy-phenyl)chromen-4-one, BiomolKI2_000011, PD 98,059, solid, Lopac0_001028, BMK1-B1, BSPBio_000996, KBioGR_000336, KBioSS_000336, MLS006010134, SCHEMBL157826, GTPL5241, 2''-amino-3''-methoxyflavone, BCBcMAP01_000049, KBio2_000336, KBio2_002904, KBio2_005472, KBio3_000671, KBio3_000672, DTXSID40168416, BCPP000123, Bio1_000475, Bio1_000964, Bio1_001453, Bio2_000338, Bio2_000818, GLXC-04689, HMS1362B17, HMS1792B17, HMS1990B17, HMS3229M08, HMS3263M17, HMS3267D03, HMS3403B17, HMS3412O09, HMS3649N14, HMS3654I16, HMS3676O09, BCP02423, EX-A2127, PD 98059 [WHO-DD], Tox21_501028, BDBM50108771, HB2244, NSC679828, s1177, 2-(2-Amino-3-methoxyphenyl)chromone, AKOS015995212, BCP9001060, BP34124, CCG-100605, CS-0169, LP01028, NSC 679828, NSC-679829, SB16629, SDCCGSBI-0051000.P003, IDI1_002093, SMP2_000052, NCGC00015790-01, NCGC00015790-02, NCGC00015790-03, NCGC00015790-04, NCGC00015790-05, NCGC00015790-06, NCGC00015790-07, NCGC00015790-08, NCGC00025045-01, NCGC00025045-02, NCGC00025045-03, NCGC00025045-04, NCGC00025045-05, NCGC00179347-01, NCGC00261713-01, AC-28412, AS-19374, HY-12028, NCI60_028554, SMR001456459, SY052749, EU-0101028, FT-0716482, P-215, SW218254-2, A25454, P-4313, PD 98059 & Z-100, J-505513, SR-01000076097-1, SR-01000076097-3, SR-01000076097-6, 2-(2-amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran, BRD-K62810658-001-05-6, BRD-K62810658-001-06-4, Q27088281, 2-(2-Amino-3-methoxy-phenyl)-chromen-4-one(PD98059), PD 98059 - CAS 167869-21-8, 4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)- & Z-100
Drug Type	Small molecule
Formula	C₁₆H₁₃NO₃
SMILES	COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
InChI	1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChIKey	QFWCYNPOPKQOKV-UHFFFAOYSA-N
CAS Number	167869-21-8
ChEMBL ID	CHEMBL35482
ChEBI ID	CHEBI:77954
Drug Bank ID	DB17042
Toxicity	Organism	Test Type	Route(Dose)
Structure			Download 2D MOL 3D MOL

Pair Name	Curcumin, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Partner Name	Curcumin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
Gene Regulation	Up-regulation	Expression	PTEN	hsa5728
In Vitro Model	MGC-803	Gastric mucinous adenocarcinoma	Homo sapiens (Human)	CVCL_5334
Result	Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells

Pair Name	Bufalin, 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Partner Name	Bufalin
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BIRC5	hsa332
Gene Regulation	Up-regulation	Expression	CASP3	hsa836
In Vitro Model	NB4	Acute promyelocytic leukemia	Homo sapiens (Human)	CVCL_0005
Result	Bufalin is a potential regimen to be used in combination with conventional chemotherapeutic drugs to improve acute promyelocytic leukemia therapy.