Pair Name	Chlorogenic acid, Methotrexate
Phytochemical Name	Chlorogenic acid
Anticancer drug Name	Methotrexate
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	These results imply that CGA has perfective effect against MTX-induced liver injury. Hence CGA supplementation might be helpful in abrogation of MTX toxicity.

Pair Name	Chrysin, Paclitaxel
Phytochemical Name	Chrysin
Anticancer drug Name	Paclitaxel
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c oxidase subunit 2		Expression
Result	CR exhibited the ability to reduce oxidative DNA damage, exert anti-apoptotic and anti-inflammatory properties, and mitigate the toxic effects of Pax-induced hepatorenal toxicity.

Pair Name	Baicalin, Fluorouracil
Phytochemical	Baicalin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Baicalin inhibits GC and enhances 5-Fu by promoting ROS-related ferroptosis in GC.

Pair Name	Crocin, Sorafenib
Phytochemical	Crocin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	CR potentiates the suppressive effects of SB on tumor growth and provides the opportunity to strengthen the therapeutic effects of SB in the treatment of HCC.

Pair Name	Curcumin, Nimustine
Phytochemical	Curcumin
Drug	Nimustine
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-kappaB/COX-2 signaling pathways

Pair Name	Dihydroberberine, Sunitinib
Phytochemical	Dihydroberberine
Drug	Sunitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	DCS induced the expression of cell cycle signal molecules that are known to be affected by JNK and p38. The change of cell cycle, in turn, led to down-regulation of JNK and p38, and further reduced IL-1 secretion. Collectively, these findings highlight potential molecular mechanisms of DCS chemotherapeutic activity and suggest that DCS is an efficacious strategy in NSCLC therapy.

Pair Name	Eugenol, Gemcitabine
Phytochemical	Eugenol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	The results suggest that eugenol exerts its anticancer activities via apoptosis induction and anti-inflammatory properties and also provide the first evidence demonstrating synergism between eugenol and gemcitabine, which may enhance The therapeutic index of prevention and/or treatment of cervical cancer.

Pair Name	Gamma-Tocotrienol, Capecitabine
Phytochemical	Gamma-Tocotrienol
Drug	Capecitabine
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Our results show that γ-tocotrienol can potentiate the effects of capecitabine through suppression of NF-κB-regulated markers of proliferation, invasion, angiogenesis, and metastasis.

Pair Name	Gamma-Tocotrienol, Gemcitabine
Phytochemical	Gamma-Tocotrienol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Our findings suggest that γ-T3 can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing NF-κB-mediated inflammatory pathways linked to tumorigenesis.

Pair Name	Harmine, Paclitaxel
Phytochemical	Harmine
Drug	Paclitaxel
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer

Pair Name	Oroxylin A, Fluorouracil
Phytochemical	Oroxylin A
Drug	Fluorouracil
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	The anti-hepatocellular carcinoma effects in vitro and in vivo of 5-FU and oroxylin A combinations were synergistic and oroxylin A increased the sensitivity of HepG2 cells to 5-FU by modulating the metabolic enzymes of 5-FU and apoptotic-related proteins

Pair Name	Oxymatrine, Paclitaxel
Phytochemical	Oxymatrine
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model

Pair Name	Plumbagin, Celecoxib
Phytochemical	Plumbagin
Drug	Celecoxib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Combination of Celecoxib and Plumbagin decreased melanoma cell proliferation and retarded vascular development of tumors mediated by inhibition of COX-2 and STAT3 leading to decreased levels of key cyclins key on which melanoma cell were dependent for survival.

Pair Name	Resveratrol, Celecoxib
Phytochemical	Resveratrol
Drug	Celecoxib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	This study showed that in NMU-induced mammary cancer in rats, the combination of resveratrol and celecoxib led to a significant reduction in all tumor parameters. In addition, in terms of tumor volume, the combination was more efficient than celecoxib as a single agent.

Pair Name	Salvianolic acid B, Celecoxib
Phytochemical	Salvianolic acid B
Drug	Celecoxib
Disease Info	[ICD-11: 2C31.Z]	Head and neck squamous cell carcinoma		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	These results strongly suggest that combination of Sal-B, a multifunctional anticancer agent, with low-dose celecoxib holds potential as a new preventive strategy in targeting inflammatory-associated tumor development.

Pair Name	Shikonin, Gemcitabine
Phytochemical	Shikonin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Our results suggest that shikonin can suppress the growth of human pancreatic tumors and potentiate the antitumor effects of gemcitabine through the suppression of NF-κB and NF-κB-regulated gene products.

Pair Name	Shogaol, Gemcitabine
Phytochemical	Shogaol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10.0]	Pancreatic ductal adenocarcinoma		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Our results suggest that 6-shogaol can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing of TLR4/NF-κB-mediated inflammatory pathways linked to tumorigenesis.

Pair Name	Tectorigenin, Paclitaxel
Phytochemical	Tectorigenin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	These data suggest that tectorigenin could sensitize paclitaxel-resistant human ovarian cancer cells through inactivation of the Akt/IKK/IκB/NFκB signaling pathway, and promise a new intervention to chemosensitize paclitaxel-induced cytotoxicity in ovarian cancer.

Pair Name	Thymoquinone, Fluorouracil
Phytochemical	Thymoquinone
Drug	Fluorouracil
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Our findings present the first report describing the in vivo enhancement effect of combined TQ and 5-FU against early stages of CRC; however, further studies are required to determine the value of this combination therapy in an advanced long-term model of CRC and also to realize its clinical potential.

Pair Name	Zerumbone, Nimesulide
Phytochemical	Zerumbone
Drug	Nimesulide
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Cytochrome c oxidase subunit 2		Expression
Result	Our results suggest that ZER is a novel food factor for mitigating experimental UC and that use of a combination of agents, with different modes of actions, may be an effective anti-inflammatory strategy.