Pair Name	(-)-Catechin gallate, Sorafenib
Phytochemical Name	(-)-Catechin gallate
Anticancer drug Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Standard-dose Sorafenib and the combination of low-dose Sorafenib and epigallo-3-catechin gallate have similar effectivity in reducing the expression of microvascular density and could prevent resistance and lower toxicity effects.

Pair Name	Amygdalin, Sorafenib
Phytochemical Name	Amygdalin
Anticancer drug Name	Sorafenib
Disease Info	[ICD-11: 2D91]	Ehrlich ascites carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Amy improved the antitumor effect of Sor and had a protective role on liver damage induced by EAC in mice.

Pair Name	Carvacrol, Sorafenib
Phytochemical Name	Carvacrol
Anticancer drug Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	CARV/Sora is a promising combination for tumor suppression and overcoming Sora resistance and cardiotoxicity in HCC by modulating TRPM7. To our best knowledge, this study represents the first study to investigate the efficiency of CARV/ Sora on the HCC rat model. Moreover, no previous studies have reported the effect of inhibiting TRPM7 on HCC.

Pair Name	Curcumin, Quinacrine
Phytochemical Name	Curcumin
Anticancer drug Name	Quinacrine
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A

Pair Name	Honokiol, Celecoxib
Phytochemical Name	Honokiol
Anticancer drug Name	Celecoxib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The combined treatment with PV-CXB and PV-HNK showed synergistic effect both in vitro and in vivo

Pair Name	Ilexgenin A, Sorafenib
Phytochemical Name	Ilexgenin A
Anticancer drug Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The results described in the present study identifies Ilexgenin A as a promising therapeutic candidate that modulates inflammation, angiogenesis, and HCC growth.

Pair Name	Polydatin, 2-Deoxy-d-glucose
Phytochemical Name	Polydatin
Anticancer drug Name	2-Deoxy-d-glucose
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Our study demonstrates that PD synergised with 2-DG to enhance its anti-cancer efficacy by inhibiting the ROS/PI3K/AKT/HIF-1α/HK2 signalling axis, providing a potential anti-cancer strategy.

Pair Name	[6]-Gingerol, Cisplatin
Phytochemical	[6]-Gingerol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The findings of the present study demonstrated that the cisplatin and 6-gingerol combination is more effective in inducing apoptosis and suppressing the angiogenesis of ovarian cancer cells than using each drug alone.

Pair Name	4'-Hydroxywogonin, Wortmannin
Phytochemical	4'-Hydroxywogonin
Drug	Wortmannin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	4'-HW decreased the viability and reduced angiogenesis in CRC, which was associated with downregulation of VEGF-A expression by disrupting the PI3K/AKT pathway. Our discoveries suggested 4'-HW as a promising anticancer agent against CRC targeting angiogenesis.

Pair Name	Amentoflavone, Sorafenib
Phytochemical	Amentoflavone
Drug	Sorafenib
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Amentoflavone may sensitize OS to sorafenib treatment by inducing intrinsic and extrinsic apoptosis and inhibiting ERK/NF-κB signaling transduction.

Pair Name	Astaxanthin, Sorafenib
Phytochemical	Astaxanthin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Astaxanthin Augmented the Anti-Hepatocellular Carcinoma Efficacy of Sorafenib Through the Inhibition of the JAK2/STAT3 Signaling Pathway and Mitigation of Hypoxia within the Tumor Microenvironment

Pair Name	Baicalin, Fluorouracil
Phytochemical	Baicalin
Drug	Fluorouracil
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	BA is a promising preventive or adjuvant therapy in breast cancer treatment with 5-FU mainly via cooperative inhibition of inflammation, angiogenesis, and triggering apoptotic cell death.

Pair Name	Bergamottin, Simvastatin
Phytochemical	Bergamottin
Drug	Simvastatin
Disease Info	[ICD-11: 2A20.1]	Chronic myelogenous leukemia		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Discussion and conclusion Our results provide novel insight into the role of SV and BGM in potentially preventing and treating cancer through modulation of NF-κB signalling pathway and its regulated gene products.

Pair Name	Beta-Elemene, Bevacizumab
Phytochemical	Beta-Elemene
Drug	Bevacizumab
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Bevacizumab exerts a synergistic effect with β-elemene in suppressing the growth of tumors derived from HCT-116 cells, and the related mechanisms may include the inhibition of tumor cell proliferation and tumor angiogenesis and the promotion of tumor cell apoptosis.

Pair Name	Biochanin A, Fluorouracil
Phytochemical	Biochanin A
Drug	Fluorouracil
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The synergistic antitumor effect of Bio-A/ 5-FU combination can be, at least partly, attributed to Bio-A-mediated suppression of ER-α/Akt axis and the augmentation of 5-FU-mediated proapoptotic effects.

Pair Name	Bisdemethoxycucurmin, Icotinib
Phytochemical	Bisdemethoxycucurmin
Drug	Icotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Our data indicate that BMDC has the potential to improve the treatment of primary EGFR-TKI resistant NISCLC that cannot be controlled with single-target agent, such as icotinib.

Pair Name	Brassinolid, Doxorubicin
Phytochemical	Brassinolid
Drug	Doxorubicin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Vascular endothelial growth factor A		Expression
Result	These data indicate that EB, a natural product with widespread occurrence in plants, is pharmacologically active in both drug-sensitive and drug-resistant SCLC cells and acts through the Wnt signaling pathway.

Pair Name	Bufalin, Sorafenib
Phytochemical	Bufalin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The results revealed a synergistic anti-hepatoma effect of bufalin combined with sorafenib via affecting the tumor vascular microenvironment by targeting mTOR/VEGF signaling.

Pair Name	Cordycepin, Apatinib
Phytochemical	Cordycepin
Drug	Apatinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Our findings demonstrated that the combination of cordycepin and apatinib has synergistically anticancer effect on NSCLC cells by down-regulating VEGF/PI3K/Akt signaling pathway. This result indicated that cordycepin and apatinib could be a promising drug combination against NSCLC.

Pair Name	Crocin, Metformin
Phytochemical	Crocin
Drug	Metformin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	These findings suggest that a combination of crocin and metformin could serve as a novel therapeutic approach to enhance the effectiveness of metastatic breast cancer therapy.

Pair Name	Curcumin, Arsenic oxide (As2O3)
Phytochemical	Curcumin
Drug	Arsenic oxide (As2O3)
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The antitumor effects of combination therapy with As2O3 and Curcumin have been displayed on prostate cancer cell lines (LNCaP and PC3), which probably originates from their potential to induce apoptosis and inhibit the growth of prostate cancer cells simultaneously.

Pair Name	Epigallocatechin gallate, Metformin
Phytochemical	Epigallocatechin gallate
Drug	Metformin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Anti-proliferative and anti-apoptotic potential effects of epigallocatechin-3-gallate and/or metformin on hepatocellular carcinoma cells: in vitro study

Pair Name	Epigallocatechin gallate, TNF-related apoptosis inducing ligand
Phytochemical	Epigallocatechin gallate
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis

Pair Name	Erianin, Afatinib
Phytochemical	Erianin
Drug	Afatinib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	EBTP/Afa targets VEGF and EGFR signaling pathways in liver cancer cells and tumor vasculature, thereby inhibiting the proliferation, motion and angiogenesis of liver cancer cells. Overall, this study provides a new combined strategy for the clinical treatment of hepatocellular carcinoma.

Pair Name	Evening primrose oil, Tamoxifen
Phytochemical	Evening primrose oil
Drug	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The most significant finding of this study was the confirmation of the anticancer activity of the natural product EPO, which potentiated the activity of the anticancer drug TAM against MCF-7 and MDA-MB-231 BC cell lines through the induction of apoptosis, inhibiting angiogenesis and halting cell proliferation.

Pair Name	Gambogic Acid, Sunitinib
Phytochemical	Gambogic Acid
Drug	Sunitinib
Disease Info	[ICD-11: 2C90.0]	Renal cell carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Our results show that the joint use of GA and SU can provide greater antitumor efficacy compared to either drug alone and thus may offer a new treatment strategy for renal cell carcinoma.

Pair Name	Gamma-Tocotrienol, Capecitabine
Phytochemical	Gamma-Tocotrienol
Drug	Capecitabine
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Our results show that γ-tocotrienol can potentiate the effects of capecitabine through suppression of NF-κB-regulated markers of proliferation, invasion, angiogenesis, and metastasis.

Pair Name	Gamma-Tocotrienol, Capecitabine
Phytochemical	Gamma-Tocotrienol
Drug	Capecitabine
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Our findings suggest that γ-T3 inhibited the growth of human CRC and sensitised CRC to capecitabine by regulating proteins linked to tumourigenesis.

Pair Name	Gamma-Tocotrienol, Gemcitabine
Phytochemical	Gamma-Tocotrienol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Our findings suggest that γ-T3 can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing NF-κB-mediated inflammatory pathways linked to tumorigenesis.

Pair Name	Garcinol, Paclitaxel
Phytochemical	Garcinol
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model

Pair Name	Ginsenoside Rg3, Endostar
Phytochemical	Ginsenoside Rg3
Drug	Endostar
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug, and it can inhibit angiogenesis and cell invasion, and enhance cell autophagy.

Pair Name	Glucosinalbate, Doxorubicin
Phytochemical	Glucosinalbate
Drug	Doxorubicin
Disease Info	[ICD-11: 2C90]	Ehrlich ascites carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The present study clearly suggested therapeutic benefit of I3C in combination with DOX by augmenting anticancer efficacy and diminishing toxicity to the host.

Pair Name	Gossypol, Ponatinib
Phytochemical	Gossypol
Drug	Ponatinib
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Gossypol could be used as an adjuvant medication for ponatinib in cancer treatment, possibly leading to successful dose reductions and fewer side effects; however, further research is needed before a clinical application could be feasible.

Pair Name	Liquiritigenin, [4-({6-[Allyl(methyl)amino]hexyl}oxy)-2-fluorophenyl](4-bromophenyl)methanone
Phytochemical	Liquiritigenin
Drug	[4-({6-[Allyl(methyl)amino]hexyl}oxy)-2-fluorophenyl](4-bromophenyl)methanone
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The ERβ ligand LQ significantly enhanced the inhibition of breast-cancer cell viability and tumor-xenograft growth by RO. The anti-tumor properties of RO may in part be due to an off-target effect that reduces ERα and increases ERβ, the latter of which can then interact with LQ to promote anti-proliferative effects. The RO + LQ combination may have value when considering novel treatment strategies for hormone-dependent breast cancer.

Pair Name	Matairesinol, Fluorouracil
Phytochemical	Matairesinol
Drug	Fluorouracil
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells

Pair Name	Noscapine, Doxorubicin
Phytochemical	Noscapine
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Noscapine potentiated the anticancer activity of Doxorubicin in a synergistic manner against TNBC tumors via inactivation of NF-KB and anti-angiogenic pathways while stimulating apoptosis. These findings suggest potential benefit for use of oral Noscapine and Doxorubicin combination therapy for treatment of more aggressive TNBC.

Pair Name	Noscapine, Gemcitabine
Phytochemical	Noscapine
Drug	Gemcitabine
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Nos potentiated the anticancer activity of Gem in an additive to synergistic manner against lung cancer via antiangiogenic and apoptotic pathways. These findings suggest potential benefit for use of NGC chemotherapy for treatment of lung cancer.

Pair Name	Oxymatrine, Paclitaxel
Phytochemical	Oxymatrine
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Oxymatrine Attenuates Tumor Growth and Deactivates STAT5 Signaling in a Lung Cancer Xenograft Model

Pair Name	Parthenolide, Balsalazide
Phytochemical	Parthenolide
Drug	Balsalazide
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	These results demonstrate that parthenolide potentiates the efficacy of balsalazide through synergistic inhibition of NF-κB activation and the combination of dual agents prevents colon carcinogenesis from chronic inflammation.

Pair Name	Phenethyl isothiocyanate, Dasatinib
Phytochemical	Phenethyl isothiocyanate
Drug	Dasatinib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The inhibition of FAK/STAT3 signalling led to increased E-cadherin expression and reduced VEGF secretion, reducing HCC metastatic potential. Therefore, a combination of PEITC and dasatinib could be a potential therapeutic strategy for the treatment of HCC.

Pair Name	Pterostilbene, Vorinostat
Phytochemical	Pterostilbene
Drug	Vorinostat
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Our study provides preclinical evidence that Pter/SAHA combination treatment inhibits MTA1/HIF-1α tumor-promoting signaling in PCa. The beneficial outcome of combinatorial strategy using a natural agent and an approved drug for higher efficacy and less toxicity supports further development of MTA1-targeted therapies in PCa.

Pair Name	Resveratrol, Gemcitabine
Phytochemical	Resveratrol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	These results suggest that VEGF-B signaling pathway plays an important role in the development of PaCa and combination of GEM and RSV would be a promising modality for clinical PaCa therapy.

Pair Name	Resveratrol, Sorafenib
Phytochemical	Resveratrol
Drug	Sorafenib
Disease Info	[ICD-11: 2C90.0]	Renal cell carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	PEGylated resveratrol combined with sorafenib can achieve synergistic anti-RCC activity, and the mechanism may be related to the inhibition of Akt/mTOR/p70S6k-4EBP-1 and c-Raf7MEK/ERK signaling pathways.

Pair Name	Rosmarinic acid, Paclitaxel
Phytochemical	Rosmarinic acid
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Rosmarinic acid exerted chemo-preventive and therapeutic potential alone or in combination with Paclitaxel. Moreover, rosmarinic acid targets numerous signaling pathways associated with breast cancer.

Pair Name	Shikonin, Gemcitabine
Phytochemical	Shikonin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Our results suggest that shikonin can suppress the growth of human pancreatic tumors and potentiate the antitumor effects of gemcitabine through the suppression of NF-κB and NF-κB-regulated gene products.

Pair Name	Tanshinone IIA, Imatinib
Phytochemical	Tanshinone IIA
Drug	Imatinib
Disease Info	[ICD-11: 2A20.1]	Chronic myelogenous leukemia		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The results revealed that Tan IIA enhanced the inhibitory effect of imatinib on TIB‑152 cell proliferation, migration and invasion, and induced apoptosis, which may be associated with inhibition of the PI3K/AKT/mTOR signaling pathway.

Pair Name	Tetrahydrocurcumin, Celecoxib
Phytochemical	Tetrahydrocurcumin
Drug	Celecoxib
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The combinational treatment effect of THC and celecoxib causing inhibition of tumor growth and tumor angiogenesis via down-regulation of VEGF, COX-2 and EGFR expression. However, this combined treatment did not show the synergistic effect on inhibiting the tumor growth and tumor angiogenesis in cervical cancer (CaSki)-implanted nude mice model.

Pair Name	Tetrandrine, Cisplatin
Phytochemical	Tetrandrine
Drug	Cisplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo

Pair Name	Thymoquinone, Bortezomib
Phytochemical	Thymoquinone
Drug	Bortezomib
Disease Info	[ICD-11: 2A85.5]	Mantle cell lymphoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-KappaB regulated gene products in multiple myeloma xenograft mouse model

Pair Name	Thymoquinone, Fluorouracil
Phytochemical	Thymoquinone
Drug	Fluorouracil
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	Our findings present the first report describing the in vivo enhancement effect of combined TQ and 5-FU against early stages of CRC; however, further studies are required to determine the value of this combination therapy in an advanced long-term model of CRC and also to realize its clinical potential.

Pair Name	Thymoquinone, Propranolol
Phytochemical	Thymoquinone
Drug	Propranolol
Disease Info	[ICD-11: 2C23.Z]	Laryngeal cancer		Investigative
Regulate Info	Up-regulation	Vascular endothelial growth factor A		Expression
Result	The effect of thymoquinone and propranolol combination on epidermoid laryngeal carcinoma cell.

Pair Name	Zerumbone, Cisplatin
Phytochemical	Zerumbone
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Vascular endothelial growth factor A		Expression
Result	The current study indicates that the treatment of 4.62 μM of ZER combined with 1.93 μM of CIS in human liver cancer cells exerts synergistic effects on cell growth inhibition, apoptosis induction, angiogenesis, and invasion by modulating gene expression.

Pair Name	Zerumbone, Gefitinib
Phytochemical	Zerumbone
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Vascular endothelial growth factor A		Expression
Result	Our study suggested that zerumbone combined with gefitinib could effectively inhibit lung cancer for multi-model therapies, including the inhibition of tumor growth, angiogenesis, induce cell apoptosis, and ferroptosis.