InterPAD - DETAILS

disulfiram, Tetraethylthiuram disulfide, 97-77-8, Antabuse, Bis(diethylthiocarbamoyl) disulfide, Antabus, Alcophobin, Anticol, Esperal, Teturam, TETD, Dicupral, Exhorran, Hoca, Ethyldithiurame, Abstensil, Antaethyl, Antietanol, Antivitium, Contralin, Tetradine, Tetraetil, Teturamin, Abstinil, Abstinyl, Antadix, Antalcol, Antetan, Antetil, Antietil, Antikol, Aversan, Averzan, Cronetal, Krotenal, Refusal, Etabus, Ethyl tuads, Ethyl Thiram, Ethyl Thiurad, Ethyl Tuex, Antaenyl, Antaetil, Antiaethan, Contrapot, Disulfan, Disulfuram, Ephorran, Stopetyl, Thiuranide, Anteyl, Bonibal, Disetil, Nocbin, Tenurid, Tenutex, Tetidis, Ekagom TEDS, Ekagom TETDS, Ethyldithiourame, Noxal, Anti-ethyl, Alk-aubs, Tetraethylthiuram disulphide, Thiuram E, TATD, Soxinol TET, Tetraethylthiram disulfide, Ekagom DTET, Accel TET, Espenal, Exhoran, Sanceler TET-G, Ro-sulfiram, Tetraethylthioperoxydicarbonic diamide, Tetraethylthiuram, Tuads, ethyl, Usaf B-33, Sanceler TET, Stopaethyl, Thireranide, Antaethan, Antethyl, Tetradin, Tillram, Accel TET-R, Ethyl Thiudad, Dupon 4472, Tetraethylthiuran disulfide, Anthethyl, Disulphuram, Dupont fungicide 4472, Hocakrotenalnci-C02959, Tetraethylthiram disulphide, Bis(diethylthiocarbamyl) disulfide, Tetraethylthiuram sulfide, Thiuram disulfide, tetraethyl-, N,N,N',N'-Tetraethylthiuram disulfide, Antabuse (TN), Bis(N,N-diethylthiocarbamoyl) disulfide, 1,1'-Dithiobis(N,N-diethylthioformamide), Disulfide, bis(diethylthiocarbamoyl), ENT 27,340, Thioperoxydicarbonic diamide, tetraethyl-, Bis(diethylthiocarbamoyl)disulphide, NCI-C02959, diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate, NSC-25953, N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide, NSC 190940, Bis(N,N-diethylthiocarbamoyl)disulphide, N,N,N',N'-Tetraethylthiuram disulphide, Bis((diethylamino)thioxomethyl)disulphide, Bis((diethylamino)thioxomethyl) disulfide, Tetraethylthiuram disulfide;TETD, TTS, TR3MLJ1UAI, MFCD00009048, Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl-, CHEMBL964, MLS000069818, CHEBI:4659, ORA102, DTXSID1021322, ORA-102, NSC25953, Esperal [France], CAS-97-77-8, NCGC00016000-08, NCGC00016000-13, SMR000059171, Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-, 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane, Ancazide ET, Akrochem TETD, Perkacit TETD, Ekaland TETD, Perkait TETD, Ethyl Tuads Rodform, C10H20N2S4, DTXCID101322, Disulfiramum [INN-Latin], Disulfiramo [INN-Spanish], Bis[(diethylamino)thioxomethyl] disulfide, CCRIS 582, 1,1'-Dithiobis[N,N-diethylthioformamide], HSDB 3317, SR-01000076145, UNII-TR3MLJ1UAI, EINECS 202-607-8, NSC 25953, AI3-27340, Formamide, 1,1'-dithiobis(N,N-diethylthio-, Thioperoxydicarbonic diamide (((H2N)C(S))2S2), N,N,N',N'-tetraethyl-, Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetraethyl-, Disulfiram [USP:INN:BAN:JAN], Bis(diethylthiocarbamyoyl)disulfide, Prestwick_182, Disulfiram (Antabuse), Spectrum_001010, CPD000059171, Disulfiram (Antabuse)?, DISULFIRAM [MI], Opera_ID_224, DISULFIRAM [INN], DISULFIRAM [JAN], Prestwick0_000097, Prestwick1_000097, Prestwick2_000097, Prestwick3_000097, Spectrum2_001176, Spectrum3_000405, Spectrum4_000228, Spectrum5_001590, DISULFIRAM [HSDB], DISULFIRAM [IARC], Lopac-T-1132, 1,N-diethylthioformamide], DISULFIRAM [VANDF], Formamide, 1,1'-dithiobis(N,N-diethylthio)-, UPCMLD-DP090, EC 202-607-8, T 1132, tetraethyl thiuram disulfide, DISULFIRAM [MART.], Tetraethyldithiuram disulfide, DISULFIRAM [WHO-DD], Lopac0_001164, SCHEMBL27213, BSPBio_000054, BSPBio_001930, KBioGR_000895, KBioSS_001490, MLS000758264, MLS001076475, MLS001423963, SPECTRUM1500262, SPBio_001191, SPBio_001993, BPBio1_000060, Disulfiram (JP17/USP/INN), GTPL7168, DISULFIRAM [EP IMPURITY], DISULFIRAM [ORANGE BOOK], UPCMLD-DP090:001, KBio2_001490, KBio2_004058, KBio2_006626, KBio3_001150, DISULFIRAM [EP MONOGRAPH], Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetraethyl-, DISULFIRAM [USP MONOGRAPH], HMS1568C16, HMS1920I16, HMS2051M17, HMS2090C18, HMS2091O22, HMS2095C16, HMS2230K06, HMS3263J09, HMS3371B21, HMS3393M17, HMS3655I19, HMS3712C16, HMS3867H13, Pharmakon1600-01500262, BCP07331, HY-B0240, bis-(diethyl-thiocarbamyl)-disulfide, Tox21_110280, Tox21_300403, Tox21_400072, Tox21_501164, BDBM50058655, CCG-39549, DL-379, HB1119, N,N',N'-Tetraethylthiuram disulfide, NSC756748, NSC800739, s1680, STL069539, 1,1',1'',1'''-{disulfanediylbis[(thioxomethylene)-nitrilo]}tetraethane, AKOS000120201, Tox21_110280_1, AT13284, DB00822, HS-0057, LP01164, NC00063, NSC-756748, NSC-800739, SDCCGSBI-0051131.P005, WLN: 2N2 & YUS & S 2, NCGC00016000-01, NCGC00016000-02, NCGC00016000-03, NCGC00016000-04, NCGC00016000-05, NCGC00016000-06, NCGC00016000-07, NCGC00016000-09, NCGC00016000-10, NCGC00016000-11, NCGC00016000-12, NCGC00016000-14, NCGC00016000-15, NCGC00016000-18, NCGC00016000-29, NCGC00094423-01, NCGC00094423-02, NCGC00094423-03, NCGC00094423-05, NCGC00094423-06, NCGC00094423-07, NCGC00254447-01, NCGC00261849-01, N,N,N'',N''-tetraethylthiuram disulfide, BIS(DIETHYLTHIOCARBAMOYL) DISULPHIDE, Formamide,1'-dithiobis(N,N-diethylthio)-, SBI-0051131.P004, 1,1''-dithiobis(N,N-diethylthioformamide), DB-057683, AB00051976, B0479, EU-0101164, FT-0631502, FT-0667720, NS00010096, SW196492-4, Tetraethylthiuram disulfide, >=97.0% (S), EN300-19458, C01692, D00131, S00294, AB00051976-20, AB00051976-21, AB00051976-23, AB00051976_22, AB00051976_25, A845750, Q409665, Q-201812, SR-01000076145-1, SR-01000076145-5, SR-01000076145-8, BRD-K32744045-001-05-6, BRD-K32744045-001-17-1, Z104473910, Disulfiram, British Pharmacopoeia (BP) Reference Standard, Disulfiram, European Pharmacopoeia (EP) Reference Standard, Disulfiram, United States Pharmacopeia (USP) Reference Standard, 1,1'',1'''',1''''''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane, Disulfiram, Pharmaceutical Secondary Standard; Certified Reference Material, N,N-diethylcarbamodithioic acid [[diethylamino(sulfanylidene)methyl]thio] ester, THIOPEROXYDICARBONIC DIAMIDE ((H2N)C(S))(SUB 2) S(SUB 2), TETRAETHYL-, InChI=1/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H, TETRAETHYLTHIOPEROXYDICARBONIC DIAMIDE ((((C(SUB 2)H(SUB 5))(SUB 2)N)C(S))(SUB 2)S(SUB 2))

Name	Disulfiram
PubChem CID	3117
Molecular Weight	296.5g/mol
Synonyms	disulfiram, Tetraethylthiuram disulfide, 97-77-8, Antabuse, Bis(diethylthiocarbamoyl) disulfide, Antabus, Alcophobin, Anticol, Esperal, Teturam, TETD, Dicupral, Exhorran, Hoca, Ethyldithiurame, Abstensil, Antaethyl, Antietanol, Antivitium, Contralin, Tetradine, Tetraetil, Teturamin, Abstinil, Abstinyl, Antadix, Antalcol, Antetan, Antetil, Antietil, Antikol, Aversan, Averzan, Cronetal, Krotenal, Refusal, Etabus, Ethyl tuads, Ethyl Thiram, Ethyl Thiurad, Ethyl Tuex, Antaenyl, Antaetil, Antiaethan, Contrapot, Disulfan, Disulfuram, Ephorran, Stopetyl, Thiuranide, Anteyl, Bonibal, Disetil, Nocbin, Tenurid, Tenutex, Tetidis, Ekagom TEDS, Ekagom TETDS, Ethyldithiourame, Noxal, Anti-ethyl, Alk-aubs, Tetraethylthiuram disulphide, Thiuram E, TATD, Soxinol TET, Tetraethylthiram disulfide, Ekagom DTET, Accel TET, Espenal, Exhoran, Sanceler TET-G, Ro-sulfiram, Tetraethylthioperoxydicarbonic diamide, Tetraethylthiuram, Tuads, ethyl, Usaf B-33, Sanceler TET, Stopaethyl, Thireranide, Antaethan, Antethyl, Tetradin, Tillram, Accel TET-R, Ethyl Thiudad, Dupon 4472, Tetraethylthiuran disulfide, Anthethyl, Disulphuram, Dupont fungicide 4472, Hocakrotenalnci-C02959, Tetraethylthiram disulphide, Bis(diethylthiocarbamyl) disulfide, Tetraethylthiuram sulfide, Thiuram disulfide, tetraethyl-, N,N,N',N'-Tetraethylthiuram disulfide, Antabuse (TN), Bis(N,N-diethylthiocarbamoyl) disulfide, 1,1'-Dithiobis(N,N-diethylthioformamide), Disulfide, bis(diethylthiocarbamoyl), ENT 27,340, Thioperoxydicarbonic diamide, tetraethyl-, Bis(diethylthiocarbamoyl)disulphide, NCI-C02959, diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate, NSC-25953, N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide, NSC 190940, Bis(N,N-diethylthiocarbamoyl)disulphide, N,N,N',N'-Tetraethylthiuram disulphide, Bis((diethylamino)thioxomethyl)disulphide, Bis((diethylamino)thioxomethyl) disulfide, Tetraethylthiuram disulfide;TETD, TTS, TR3MLJ1UAI, MFCD00009048, Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl-, CHEMBL964, MLS000069818, CHEBI:4659, ORA102, DTXSID1021322, ORA-102, NSC25953, Esperal [France], CAS-97-77-8, NCGC00016000-08, NCGC00016000-13, SMR000059171, Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-, 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane, Ancazide ET, Akrochem TETD, Perkacit TETD, Ekaland TETD, Perkait TETD, Ethyl Tuads Rodform, C10H20N2S4, DTXCID101322, Disulfiramum [INN-Latin], Disulfiramo [INN-Spanish], Bis[(diethylamino)thioxomethyl] disulfide, CCRIS 582, 1,1'-Dithiobis[N,N-diethylthioformamide], HSDB 3317, SR-01000076145, UNII-TR3MLJ1UAI, EINECS 202-607-8, NSC 25953, AI3-27340, Formamide, 1,1'-dithiobis(N,N-diethylthio-, Thioperoxydicarbonic diamide (((H2N)C(S))2S2), N,N,N',N'-tetraethyl-, Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetraethyl-, Disulfiram [USP:INN:BAN:JAN], Bis(diethylthiocarbamyoyl)disulfide, Prestwick_182, Disulfiram (Antabuse), Spectrum_001010, CPD000059171, Disulfiram (Antabuse)?, DISULFIRAM [MI], Opera_ID_224, DISULFIRAM [INN], DISULFIRAM [JAN], Prestwick0_000097, Prestwick1_000097, Prestwick2_000097, Prestwick3_000097, Spectrum2_001176, Spectrum3_000405, Spectrum4_000228, Spectrum5_001590, DISULFIRAM [HSDB], DISULFIRAM [IARC], Lopac-T-1132, 1,N-diethylthioformamide], DISULFIRAM [VANDF], Formamide, 1,1'-dithiobis(N,N-diethylthio)-, UPCMLD-DP090, EC 202-607-8, T 1132, tetraethyl thiuram disulfide, DISULFIRAM [MART.], Tetraethyldithiuram disulfide, DISULFIRAM [WHO-DD], Lopac0_001164, SCHEMBL27213, BSPBio_000054, BSPBio_001930, KBioGR_000895, KBioSS_001490, MLS000758264, MLS001076475, MLS001423963, SPECTRUM1500262, SPBio_001191, SPBio_001993, BPBio1_000060, Disulfiram (JP17/USP/INN), GTPL7168, DISULFIRAM [EP IMPURITY], DISULFIRAM [ORANGE BOOK], UPCMLD-DP090:001, KBio2_001490, KBio2_004058, KBio2_006626, KBio3_001150, DISULFIRAM [EP MONOGRAPH], Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetraethyl-, DISULFIRAM [USP MONOGRAPH], HMS1568C16, HMS1920I16, HMS2051M17, HMS2090C18, HMS2091O22, HMS2095C16, HMS2230K06, HMS3263J09, HMS3371B21, HMS3393M17, HMS3655I19, HMS3712C16, HMS3867H13, Pharmakon1600-01500262, BCP07331, HY-B0240, bis-(diethyl-thiocarbamyl)-disulfide, Tox21_110280, Tox21_300403, Tox21_400072, Tox21_501164, BDBM50058655, CCG-39549, DL-379, HB1119, N,N',N'-Tetraethylthiuram disulfide, NSC756748, NSC800739, s1680, STL069539, 1,1',1'',1'''-{disulfanediylbis[(thioxomethylene)-nitrilo]}tetraethane, AKOS000120201, Tox21_110280_1, AT13284, DB00822, HS-0057, LP01164, NC00063, NSC-756748, NSC-800739, SDCCGSBI-0051131.P005, WLN: 2N2 & YUS & S 2, NCGC00016000-01, NCGC00016000-02, NCGC00016000-03, NCGC00016000-04, NCGC00016000-05, NCGC00016000-06, NCGC00016000-07, NCGC00016000-09, NCGC00016000-10, NCGC00016000-11, NCGC00016000-12, NCGC00016000-14, NCGC00016000-15, NCGC00016000-18, NCGC00016000-29, NCGC00094423-01, NCGC00094423-02, NCGC00094423-03, NCGC00094423-05, NCGC00094423-06, NCGC00094423-07, NCGC00254447-01, NCGC00261849-01, N,N,N'',N''-tetraethylthiuram disulfide, BIS(DIETHYLTHIOCARBAMOYL) DISULPHIDE, Formamide,1'-dithiobis(N,N-diethylthio)-, SBI-0051131.P004, 1,1''-dithiobis(N,N-diethylthioformamide), DB-057683, AB00051976, B0479, EU-0101164, FT-0631502, FT-0667720, NS00010096, SW196492-4, Tetraethylthiuram disulfide, >=97.0% (S), EN300-19458, C01692, D00131, S00294, AB00051976-20, AB00051976-21, AB00051976-23, AB00051976_22, AB00051976_25, A845750, Q409665, Q-201812, SR-01000076145-1, SR-01000076145-5, SR-01000076145-8, BRD-K32744045-001-05-6, BRD-K32744045-001-17-1, Z104473910, Disulfiram, British Pharmacopoeia (BP) Reference Standard, Disulfiram, European Pharmacopoeia (EP) Reference Standard, Disulfiram, United States Pharmacopeia (USP) Reference Standard, 1,1'',1'''',1''''''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane, Disulfiram, Pharmaceutical Secondary Standard; Certified Reference Material, N,N-diethylcarbamodithioic acid [[diethylamino(sulfanylidene)methyl]thio] ester, THIOPEROXYDICARBONIC DIAMIDE ((H2N)C(S))(SUB 2) S(SUB 2), TETRAETHYL-, InChI=1/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H, TETRAETHYLTHIOPEROXYDICARBONIC DIAMIDE ((((C(SUB 2)H(SUB 5))(SUB 2)N)C(S))(SUB 2)S(SUB 2))
Drug Type	Small molecule
Formula	C₁₀H₂₀N₂S₄
SMILES	CCN(CC)C(=S)SSC(=S)N(CC)CC
InChI	1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
InChIKey	AUZONCFQVSMFAP-UHFFFAOYSA-N
CAS Number	97-77-8
ChEMBL ID	CHEMBL964
ChEBI ID	CHEBI:4659
TTD ID	D0X5SD
Drug Bank ID	DB00822
KEGG ID	C01692
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Pair Name	Curcumin, Disulfiram
Partner Name	Curcumin
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Biological Phenomena	Induction-->Oxidative stress
In Vitro Model	B16-F10	Mouse melanoma	Mus musculus (Mouse)	CVCL_0159
In Vivo Model	Tumor cells (2×10⁶ cells per 500 μL) were implanted subcutaneously into the left hind groin of mice. The compounds were dissolved in 5% DMSO and provided to the mice intraperitoneally once a day for 15 consecutive days.
Result	Combination Therapy of Curcumin and Disulfiram Synergistically Inhibits the Growth of B16-F10 Melanoma Cells by Inducing Oxidative Stress