Pair Name	Carvacrol, Sorafenib
Phytochemical Name	Carvacrol
Anticancer drug Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	CARV/Sora is a promising combination for tumor suppression and overcoming Sora resistance and cardiotoxicity in HCC by modulating TRPM7. To our best knowledge, this study represents the first study to investigate the efficiency of CARV/ Sora on the HCC rat model. Moreover, no previous studies have reported the effect of inhibiting TRPM7 on HCC.

Pair Name	Curcumin, Quinacrine
Phytochemical Name	Curcumin
Anticancer drug Name	Quinacrine
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A

Pair Name	Tanshinone IIA, Doxorubicin
Phytochemical Name	Tanshinone IIA
Anticancer drug Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	Tan IIA could be used as a novel agent combined with Dox in breast cancer therapy.

Pair Name	Camptothecin, Sorafenib
Phytochemical	Camptothecin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	The synergetic combination significantly increases lipid peroxidation and iron concentration, decreases TAC, GPX4 and GR activity, and reduces the expression of both Nrf2 and SLC7A11. The downregulation of Nrf2 expression has a vital role in the reduction of resistance mediators to sorafenib against HCC cells like (p62, MT1G, and ABCG2) and improves the cellular uptake of sorafenib. The current study provided evidence that Nrf2 inhibition by CPT improves sorafenib's sensitivity and reduces sorafenib's resistance via the augmentation of sorafenib's ferroptosis action.

Pair Name	Curcumol, Cisplatin
Phytochemical	Curcumol
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	These findings suggest that curcumol inhibits the polarization of M2-like macrophages and could be a promising combination strategy to synergize with CDDP in the osteosarcoma.

Pair Name	Daidzein, Topotecan
Phytochemical	Daidzein
Drug	Topotecan
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	Daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.

Pair Name	Fucoxanthin, Doxorubicin
Phytochemical	Fucoxanthin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	The carotenoid fucoxanthin can sensitize multidrug resistant cancer cells to doxorubicin via induction of apoptosis, inhibition of multidrug resistance proteins and metabolic enzymes

Pair Name	Thymoquinone, Imatinib
Phytochemical	Thymoquinone
Drug	Imatinib
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	TQ potentiates IM efficacy on HCT116 cells via uptake/efflux genes modulation

Pair Name	Ursolic acid, Cisplatin
Phytochemical	Ursolic acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	UA inhibits the proliferation and reversal of drug resistance in ovarian CSCs by suppressing the expression of downregulation of HIF-1α and ABCG2.

Pair Name	Celastrol, Cisplatin
Phytochemical	Celastrol
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	Celastrol can inhibit the proliferation of the SGC7901/DDP cells, induce their apoptosis, and reduce the expression of drug resistance genes, probably by inhibiting the expression of the proteins related to the mTOR signaling pathway

Pair Name	Fisetin, Paclitaxel
Phytochemical	Fisetin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	Our study shows that PTX-FA and Fis-FA PBM NPs directly target platinum-resistant OvCa cells, induce cytotoxic/apoptotic effects, and reverse multi-drug resistance (MDR). These findings allow us to create new clinical applications using PTX-FA and Fis-FA combination nanoparticles to treat drug-resistant cancers.

Pair Name	Saikosaponin D, Gefitinib
Phytochemical	Saikosaponin D
Drug	Gefitinib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Broad substrate specificity ATP-binding cassette transporter ABCG2		Expression
Result	Saikosaponin D enhances the antitumor effect of gemcitabine by controlling glucose metabolism and drug efflux by inhibiting the ADRB2 signaling. Therefore, the combination of saikosaponin D and gemcitabine may be a potential therapeutic strategy for the treatment of iCCA.