| Name | Gap junction alpha-1 protein | ||
| UniProt ID | CXA1_HUMAN | ||
| Gene Name | GJA1 | ||
| Gene ID | 2697 | ||
| Synonyms |
GJA1, AVSD3, CMDR, CX43, EKVP, EKVP3, GJAL, HLHS1, HSS, ODDD, PPKCA
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| Sequence |
MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPG
CENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDG VNVDMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFS LSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRV KGKSDPYHATSGALSPAKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRN YNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVD QRPSSRASSRASSRPRPDDLEI |
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| Pathway Map | MAP LINK | ||
| T.C. Number | 1.A.24.1.16 | ||
| KEGG ID | hsa2697 | ||
| TTD ID | T44479 | ||
| Pfam | PF00029; PF00909; PF03508; PF13687; PF15839; PF16791; PF19904 | ||
| Pair Name | Curcumin, HSV-TK/GCV | |||
| Phytochemical | Curcumin | |||
| Drug | HSV-TK/GCV | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Regulate Info | Up-regulation | Gap junction alpha-1 protein | Expression | |
| Result | Curcumin could enhance the killing effect and the bystander effect of HSV-TK/GCV in treating melanoma, which might be mediated by improved gap junction. | |||
