Pair Name	Curcumin, Quinacrine
Phytochemical Name	Curcumin
Anticancer drug Name	Quinacrine
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A

Pair Name	Ilexgenin A, Sorafenib
Phytochemical Name	Ilexgenin A
Anticancer drug Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	The results described in the present study identifies Ilexgenin A as a promising therapeutic candidate that modulates inflammation, angiogenesis, and HCC growth.

Pair Name	Kuromanin chloride, Cisplatin
Phytochemical Name	Kuromanin chloride
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Cyanidin-3-O-glucoside and cisplatin inhibit proliferation and downregulate the PI3K/AKT/mTOR pathway in cervical cancer cells

Pair Name	Magnoflorine, Doxorubicin
Phytochemical Name	Magnoflorine
Anticancer drug Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways

Pair Name	Mangiferin, Cisplatin
Phytochemical Name	Mangiferin
Anticancer drug Name	Cisplatin
Disease Info	Nephrotoxicity			Investigative
Regulate Info	Up-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	The study reveals a mechanistic basis of mangiferin action against cisplatin induced nephrotoxicity. Since Mangiferin shows synergistic anticancer activity with cisplatin, it can be considered as a promising drug candidate, to be used in combination with cisplatin.

Pair Name	Polydatin, 2-Deoxy-d-glucose
Phytochemical Name	Polydatin
Anticancer drug Name	2-Deoxy-d-glucose
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Our study demonstrates that PD synergised with 2-DG to enhance its anti-cancer efficacy by inhibiting the ROS/PI3K/AKT/HIF-1α/HK2 signalling axis, providing a potential anti-cancer strategy.

Pair Name	Silibinin, Regorafenib
Phytochemical Name	Silibinin
Anticancer drug Name	Regorafenib
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	The present study suggests that silybin in combination with regorafenib is a promising strategy for treatment of metastatic colorectal patients.

Pair Name	[6]-Gingerol, Cisplatin
Phytochemical	[6]-Gingerol
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	[6]-Gingerol enhances the cisplatin sensitivity of gastric cancer cells through inhibition of proliferation and invasion via PI3K/AKT signaling pathway

Pair Name	2,3,5,6-Tetramethylpyrazine, Doxorubicin
Phytochemical	2,3,5,6-Tetramethylpyrazine
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	DLJ14 and Adr combination treatment may inhibit proliferation of Adr-resistant human breast cancer cells through inhibition of the EGFR/PI3K/Akt survival pathway and induction of apoptosis via the mitochondrial-mediated apoptosis pathway.

Pair Name	4'-Hydroxywogonin, Wortmannin
Phytochemical	4'-Hydroxywogonin
Drug	Wortmannin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	4'-HW decreased the viability and reduced angiogenesis in CRC, which was associated with downregulation of VEGF-A expression by disrupting the PI3K/AKT pathway. Our discoveries suggested 4'-HW as a promising anticancer agent against CRC targeting angiogenesis.

Pair Name	Aloe emodin, Gefitinib
Phytochemical	Aloe emodin
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	AE could enhance the gefitinib sensitivity of PC9-GR cells and reverse EMT by blocking PI3K/Akt/TWIS1 signal pathway.

Pair Name	Aloin, Irinotecan
Phytochemical	Aloin
Drug	Irinotecan
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	Our findings suggests that CPT-11 and Aloin are potential combination treatment partners against colorectal cancer. MicroRNA-133b may serve as a co-therapeutic target with IGF1R against colorectal cancer, which might overcome the existing treatment limitations.

Pair Name	Aloin, Metformin
Phytochemical	Aloin
Drug	Metformin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Activity
Result	Our research demonstrated that the concomitant treatment with aloin and MET enhances the antitumor effect by inhibiting the growth and invasion as well as inducing apoptosis and autophagy in HCC through PI3K/AKT/mTOR pathway.

Pair Name	Alpha-Hederin, Carboplatin
Phytochemical	Alpha-Hederin
Drug	Carboplatin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling

Pair Name	Apigenin, Doxorubicin
Phytochemical	Apigenin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	Co-administration of apigenin with doxorubicin enhances anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells

Pair Name	Beta-Elemene, Fluorouracil
Phytochemical	Beta-Elemene
Drug	Fluorouracil
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	The conclusion obtained, considering that the results suggest that the combination may be important specifically in the treatment of TNBC.

Pair Name	Beta-Elemene, Fluorouracil
Phytochemical	Beta-Elemene
Drug	Fluorouracil
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	The conclusion obtained, considering that the results suggest that the combination may be important specifically in the treatment of TNBC.

Pair Name	Cordycepin, Apatinib
Phytochemical	Cordycepin
Drug	Apatinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	Our findings demonstrated that the combination of cordycepin and apatinib has synergistically anticancer effect on NSCLC cells by down-regulating VEGF/PI3K/Akt signaling pathway. This result indicated that cordycepin and apatinib could be a promising drug combination against NSCLC.

Pair Name	Costunolide, Doxorubicin
Phytochemical	Costunolide
Drug	Doxorubicin
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	These results demonstrate that costunolide may be a potent therapeutic agent against chronic myeloid leukemia.

Pair Name	Curcumin, Docetaxel
Phytochemical	Curcumin
Drug	Docetaxel
Disease Info	[ICD-11: 2B70]	Esophageal cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	CUR combined with DTX induced apoptosis and autophagy of ESCC and probably worked through the PI3K/AKT/mTOR signaling pathway. The combination of the autophagy inhibitor, CUR and DTX may become a new treatment strategy for esophageal cancer.

Pair Name	Curcumin, Nimustine
Phytochemical	Curcumin
Drug	Nimustine
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-kappaB/COX-2 signaling pathways

Pair Name	Curcumin, Pyridoxine
Phytochemical	Curcumin
Drug	Pyridoxine
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	C + B is superior to either agent alone in preventing obesity-promoted colorectal carcinogenesis. Augmented suppression of procancerous signaling pathways may be the means by which this augmentation occurs.

Pair Name	Erianin, Afatinib
Phytochemical	Erianin
Drug	Afatinib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	EBTP/Afa targets VEGF and EGFR signaling pathways in liver cancer cells and tumor vasculature, thereby inhibiting the proliferation, motion and angiogenesis of liver cancer cells. Overall, this study provides a new combined strategy for the clinical treatment of hepatocellular carcinoma.

Pair Name	Fisetin, Fluorouracil
Phytochemical	Fisetin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Fisetin and 5-fluorouracil: Effective combination for PIK3CA-mutant colorectal cancer

Pair Name	Fisetin, Sorafenib
Phytochemical	Fisetin
Drug	Sorafenib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Fisetin potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells.

Pair Name	Fucoxanthin, TNF-related apoptosis inducing ligand
Phytochemical	Fucoxanthin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	The findings of this study suggest that the combined use of fucoxanthin and TRAIL might be a useful strategy against TRAIL-resistant cervical cancer.

Pair Name	Gamma-Tocotrienol, SU11274
Phytochemical	Gamma-Tocotrienol
Drug	SU11274
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	Suggest that combined γ-tocotrienol and Met inhibitor treatment may provide benefit in treatment of breast cancers characterized by aberrant Met activity.

Pair Name	Garcinol, Cisplatin
Phytochemical	Garcinol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	Our data demonstrated that garcinol has the potential to be used as an anticancer agent and may synergize the effect of DDP. These actions are most likely through the regulation of the PI3K/AKT and NF-κB pathways.

Pair Name	Ginsenoside Rg3, Endostar
Phytochemical	Ginsenoside Rg3
Drug	Endostar
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug, and it can inhibit angiogenesis and cell invasion, and enhance cell autophagy.

Pair Name	Ginsenoside Rg3, Sorafenib
Phytochemical	Ginsenoside Rg3
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Rg3 has a synergistic effect on the sensitivity of HepG2 and Bel7404 hepatoma cells to SFN, which is related to HK2-mediated glycolysis and the PI3K/Akt signaling pathway.

Pair Name	Gossypol, Trastuzumab
Phytochemical	Gossypol
Drug	Trastuzumab
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	The trastuzumab/AT-101 combination may be a good candidate for patients with trastuzumab-resistant Her2-positive breast cancer and inhibition of the PI3K/AKT pathway may be one of the underlying mechanisms.

Pair Name	Jervine, Decitabine
Phytochemical	Jervine
Drug	Decitabine
Disease Info	[ICD-11: 2A3Z]	Myelodysplastic syndrome		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	The Smo inhibitor jervine and its combination with decitabine have a synergistic effect on the proliferation, cell cycle, and apoptosis of MUTZ-1 cells, and its mechanism may be achieved by interfering with the Shh signaling pathway.

Pair Name	Kaempferol, Erlotinib
Phytochemical	Kaempferol
Drug	Erlotinib
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	These data imply that KAE may be a valid therapeutic candidate to potentiate PC cell sensitivity to ERL via inhibiting PI3K/AKT and EGFR signaling.

Pair Name	Kaempferol, Fluorouracil
Phytochemical	Kaempferol
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Activity
Result	The present study demonstrated that kaempferol has a synergistic effect with 5‑FU by inhibiting cell proliferation and inducing apoptosis in colorectal cancer cells via suppression of TS or attenuation of p‑Akt activation. The combination of kaempferol and 5‑FU may be used as an effective therapeutic strategy for colorectal cancer.

Pair Name	Liquiritigenin, Cisplatin
Phytochemical	Liquiritigenin
Drug	Cisplatin
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	The results suggested that LQ plays an intensive role on CDDP suppressing invasion and metastasis through regulating the PI3 K/AKT signal pathway and suppressing the protein expression of MMP-2/9.

Pair Name	Magnolin, B-RAF Inhibitors
Phytochemical	Magnolin
Drug	B-RAF Inhibitors
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Synergistic activity of magnolin combined with B-RAF inhibitor SB590885 in hepatocellular carcinoma cells via targeting PI3K-AKT/mTOR and ERK MAPK pathway

Pair Name	Myriocin, Cisplatin
Phytochemical	Myriocin
Drug	Cisplatin
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	We suggest that myriocin is a novel potent anti-cancer agent that dually targets both VEGFR2 in ECs and IκBα in cancer cells, and exerts more pronounced anti-tumor effects than with either kinase being inhibited alone.

Pair Name	Nobiletin, Vorinostat
Phytochemical	Nobiletin
Drug	Vorinostat
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	The combination of nobiletin with vorinostat increased histone H3K9 and H3K27 acetylation levels in SCLC mouse tumor tissue and enhanced the expression of the BH3-only proteins BIM and BID. We conclude that nobiletin is a novel natural BH3 mimetic that can cooperate with vorinostat to induce apoptosis and autophagy in SCLC.

Pair Name	OSW-1, Carboplatin
Phytochemical	OSW-1
Drug	Carboplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	Our data revealed the mode of action and molecular mechanism underlying the effect of OSW-1 against TNBC, and provided a useful guidance for improving the sensitivity of TNBC cells to conventional chemotherapeutic drugs, which warrants further investigation.

Pair Name	Quercitrin, Insulin
Phytochemical	Quercitrin
Drug	Insulin
Disease Info	[ICD-11: 5A80]	Polycystic ovary syndrome		Investigative
Regulate Info	Up-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	PM20D1 and PI3K/Akt were required for lipolysis and endocrine regulation in PCOS-IR to restore ovarian function and maintain normal endocrine metabolism. By upregulating the expression of PM20D1, quercitrin activated the PI3K/Akt signaling pathway, improved adipocyte catabolism, corrected reproductive and metabolic abnormalities, and had a therapeutic effect on PCOS-IR.

Pair Name	Retinoic acid, PI3K inhibitor
Phytochemical	All-trans-retinoic acid
Drug	PI3K inhibitor
Disease Info	[ICD-11: 2D4Y]	Adenoid cystic carcinoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	We displayed the morphologically and genetic featured PDXs which recapitulated the heterogeneity of original ACC tumors, indicating that the models could be used as a platform for drug screening for therapy response. The feasibility of combination treatment approaches for dual targets were confirmed, providing new regimens for personalized therapies in ACC.

Pair Name	Rhein, Oxaliplatin
Phytochemical	Rhein
Drug	Oxaliplatin
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	These data demonstrate that Rhein can induce apoptosis and enhance the oxaliplatin sensitivity of PC cells, suggesting that Rhein may be an effective strategy to overcome drug resistance in the chemotherapeutic treatment of PC.

Pair Name	Rhein, Pemetrexed
Phytochemical	Rhein
Drug	Pemetrexed
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Our findings demonstrated that the potential application of rhein as a candidate drug in combination with PTX is promising for treatment of the human lung cancer.

Pair Name	Rhizoma Paridis saponins, Sorafenib
Phytochemical	Rhizoma Paridis saponins
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	All of that provided possibility to overcome the intolerance of sorafenib by drug compatibility through protection against mitochondria damage, inhibition of anaerobic glycolysis and suppression of lipid synthesis based on PI3K/Akt/mTOR pathway.

Pair Name	Shikonin, 4-hydroxytamoxifen
Phytochemical	Shikonin
Drug	4-hydroxytamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	The combination of SK and 4-OHT shows highly efficient anticancer effects on breast cancer therapy. SK may be a promising candidate as an adjuvant to 4-OHT for breast cancer treatments, especially for ER- breast cancer.

Pair Name	Shikonin, Doxorubicin
Phytochemical	Shikonin
Drug	Doxorubicin
Disease Info	[ICD-11: 2B33.5]	Lymphoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	These data suggest that shikonin may be an encouraging chemotherapeutic agent in the clinical treatment of BL.

Pair Name	Sulforaphene, Carboplatin
Phytochemical	Sulforaphene
Drug	Carboplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	This study demonstrates that the duel character of this combination therapy may be an effective replacement for conventional therapy alone against NSCLC.

Pair Name	Sulforaphene, Cisplatin
Phytochemical	Sulforaphene
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian Cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	SFE synergistically inhibited proliferation and induced apoptosis of SKOV3 and SNU8 cells in combination with cisplatin by activating multiple apoptotic pathways. Therefore, we suggest sulforaphene as a chemo-enhancing adjuvant to improve the efficacy of cisplatin in ovarian cancer treatment.

Pair Name	Tanshinone IIA, Cisplatin
Phytochemical	Tanshinone IIA
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	The combination of Tan IIA and cisplatin exhibited the most significant difference. Tanshinone IIA may function as a novel option for combination therapy for non-small-cell lung cancer treatment.

Pair Name	Tanshinone IIA, Imatinib
Phytochemical	Tanshinone IIA
Drug	Imatinib
Disease Info	[ICD-11: 2A20.1]	Chronic myelogenous leukemia		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	The results revealed that Tan IIA enhanced the inhibitory effect of imatinib on TIB‑152 cell proliferation, migration and invasion, and induced apoptosis, which may be associated with inhibition of the PI3K/AKT/mTOR signaling pathway.

Pair Name	Tubeimoside I, Temozolomide
Phytochemical	Tubeimoside I
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	We first demonstrated that synergistic effects of TBMS1 and TMZ induced apoptosis in GBM cells through reducing MGMT expression and inhibiting the EGFR induced PI3K/Akt/mTOR/NF-κB signaling pathway. This study provides a rationale for combined application of TMZ and TBMS1 as a potential chemotherapeutic treatment for MGMT+ GBM patients.

Pair Name	Ursolic acid, Epirubicin
Phytochemical	Ursolic acid
Drug	Epirubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	These findings indicate that UA can dramatically enhance the sensitivity of MCF-7 and MDA-MB-231 cells to EPI by modulating the autophagy pathway. Our study may provide a new therapeutic strategy for combination therapy.

Pair Name	Vitamin C, Cimetidine
Phytochemical	Vitamin C
Drug	Cimetidine
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Phosphorylation
Result	We concluded that the synergistic combination provided a promising anti-neoplastic effect via reducing the angiogenesis, oxidative stress, increasing apoptosis,as well as inhibiting the activation of PI3K/AKT/mTOR cue, and suggesting its use as a treatment option for breast cancer.

Pair Name	Quercetin, Docetaxel
Phytochemical	Quercetin
Drug	Docetaxel
Disease Info	[ICD-11: 2E02]	Metastatic prostate cancer		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways

Pair Name	Tanshinone I, Epirubicin
Phytochemical	Tanshinone I
Drug	Epirubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Our results suggested that Tan I could effectively improve the anti-tumor effect of EADM, and synergize EADM to reverse HIF-1α mediated resistance via targeting PI3K/AKT/HIF-1α signaling pathway.

Pair Name	Vinpocetine, Sorafenib
Phytochemical	Vinpocetine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		Expression
Result	Vinpocetine may be a potential candidate for sorafenib sensitization and HCC treatment, and our results may help to elucidate more effective therapeutic options for HCC patients with sorafenib resistance.