Pair Name	Morusin, TNF-related apoptosis inducing ligand
Phytochemical Name	Morusin
Anticancer drug Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	These results suggest that morusin enhances TRAIL sensitivity in human glioblastoma cells through regulating expression of DR5 and EGFR. Therefore, the combination treatment of TRAIL and morusin may be a new therapeutic strategy for malignant glioma patients.

Pair Name	Triptolide, Cetuximab
Phytochemical Name	Triptolide
Anticancer drug Name	Cetuximab
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	Cet-TPL represents a potent targeting therapeutic agent against EGFR-overexpressing NSCLC and others.

Pair Name	(S)-10-Hydroxycamptothecin, Crizotinib
Phytochemical	(S)-10-Hydroxycamptothecin
Drug	Crizotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells

Pair Name	2,3,5,6-Tetramethylpyrazine, Doxorubicin
Phytochemical	2,3,5,6-Tetramethylpyrazine
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	DLJ14 and Adr combination treatment may inhibit proliferation of Adr-resistant human breast cancer cells through inhibition of the EGFR/PI3K/Akt survival pathway and induction of apoptosis via the mitochondrial-mediated apoptosis pathway.

Pair Name	Apigenin, Gefitinib
Phytochemical	Apigenin
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells

Pair Name	Berbamine, Sorafenib
Phytochemical	Berbamine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Targeting Na+/K+-ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma

Pair Name	Berberine, Erlotinib
Phytochemical	Berberine
Drug	Erlotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Our data supported use of BBR in combination with erlotinib as a novel strategy for treatment of patients with EGFR positive tumors.

Pair Name	Biochanin A, Temozolomide
Phytochemical	Biochanin A
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	Chanin A significantly enhanced the anticancer efficacy of temozolomide in GBM cells.

Pair Name	Bisdemethoxycucurmin, Icotinib
Phytochemical	Bisdemethoxycucurmin
Drug	Icotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Our data indicate that BMDC has the potential to improve the treatment of primary EGFR-TKI resistant NISCLC that cannot be controlled with single-target agent, such as icotinib.

Pair Name	Capsaicin, Sorafenib
Phytochemical	Capsaicin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	These data confirm that capsaicin and sorafenib combination treatment inhibits the growth, invasion and metastasis of HCC cells and induces autophagy in a synergistic manner, supporting its potential as a therapeutic option for HCC.

Pair Name	Curcumin, Vemurafenib
Phytochemical	Curcumin
Drug	Vemurafenib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib-resistant melanoma cells by downregulating the EGFR signaling pathway

Pair Name	Daidzein, Gefitinib
Phytochemical	Daidzein
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	Daidzein Synergizes with Gefitinib to Induce ROS/JNK/c-Jun Activation and Inhibit EGFR-STAT/AKT/ERK Pathways to enhance Lung Adenocarcinoma cells chemosensitivity

Pair Name	Gambogenic acid, Erlotinib
Phytochemical	Gambogenic acid
Drug	Erlotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Our findings provide preclinical evidence for using GNA as an FGFR signaling pathway inhibitor to overcome erlotinib resistance in NSCLC treatment or to enhance erlotinib efficacy when used as a combined administration.

Pair Name	Gossypol, Gefitinib
Phytochemical	Gossypol
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations.

Pair Name	Helichrysetin, Tumor necrosis factor-alpha
Phytochemical	Helichrysetin
Drug	Tumor necrosis factor-alpha
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Helichrysetin and TNF‑α synergistically promoted apoptosis by inhibiting TAK1/IKK/NF‑κB and TAK1/EGFR signaling pathways in HeLa and T98G cells, indicating a potential therapeutic strategy for cancer.

Pair Name	Honokiol, Fluorouracil
Phytochemical	Honokiol
Drug	Fluorouracil
Disease Info	[ICD-11: 2B62.0]	Tongue squamous cell carcinoma		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	These findings suggest that HNK and 5-FU exert a synergistic therapeutic effect on OSCC by inducing apoptosis. HNK might thus enhance the clinical therapeutic efficacy of 5-FU without increasing its toxicity.

Pair Name	Kaempferol, Erlotinib
Phytochemical	Kaempferol
Drug	Erlotinib
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	These data imply that KAE may be a valid therapeutic candidate to potentiate PC cell sensitivity to ERL via inhibiting PI3K/AKT and EGFR signaling.

Pair Name	Kaempferol, Gefitinib
Phytochemical	Kaempferol
Drug	Gefitinib
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway

Pair Name	Luteolin, Erlotinib
Phytochemical	Luteolin
Drug	Erlotinib
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	These findings suggest that combining luteolin with erlotinib offers a potential treatment strategy for glioblastoma multiforme IV.

Pair Name	Oleanolic Acid, Gemcitabine
Phytochemical	Oleanolic Acid
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	We found an interesting finding that the 73-03 in combination with GCB can improve GCB efficacy and decrease PCa resistance, which induced apoptosis and mitochondrial damage through epigenetic inhibition of SPINK1 transcription by miR-421 up-regulation. This was the first study that used OA derivatives on GCB-resistant PCa cells, so this combined strategy warrants further investigation.

Pair Name	Oridonin, Cetuximab
Phytochemical	Oridonin
Drug	Cetuximab
Disease Info	[ICD-11: 2C23.Z]	Laryngeal cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: Involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway

Pair Name	Oxidized tea polyphenol, Nimotuzumab
Phytochemical	Oxidized tea polyphenol
Drug	Nimotuzumab
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	OTP-3 can also serve as an effective therapeutic agent in NSCLC where it can augment the effects of nimotuzumab, a valuable property for combination agents.

Pair Name	Peiminine, Doxorubicin
Phytochemical	Peiminine
Drug	Doxorubicin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	Our findings indicated that sinapine played an important role in the downregulation of MDR1 expression through suppression of fibroblast growth factor receptor (FGFR)4/FRS2α-ERK1/2 mediated NF-κB activation in MCF-7/dox cancer cells.

Pair Name	Salvianolic acid B, Celecoxib
Phytochemical	Salvianolic acid B
Drug	Celecoxib
Disease Info	[ICD-11: 2C31.Z]	Head and neck squamous cell carcinoma		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	These results strongly suggest that combination of Sal-B, a multifunctional anticancer agent, with low-dose celecoxib holds potential as a new preventive strategy in targeting inflammatory-associated tumor development.

Pair Name	Sanguinarium, Cisplatin
Phytochemical	Sanguinarium
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	Our findings demonstrate that SNG induces mitochondrial and caspase-dependent apoptosis, generates oxidative stress, and suppresses MM cell lines proliferation. In addition, co-treatment of MM cell lines with sub-toxic doses of SNG and BTZ potentiated the cytotoxic activity. These results would suggest that SNG could be developed into therapeutic agent either alone or in combination with other anticancer drugs in MM.

Pair Name	Shikonin, Erlotinib
Phytochemical	Shikonin
Drug	Erlotinib
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	These results suggest that the combination of erlotinib with shikonin or its derivatives might be a potential strategy to overcome drug resistance to erlotinib.

Pair Name	Sulforaphane, CB-5083
Phytochemical	Sulforaphane
Drug	CB-5083
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	The combination of Sulforaphane and CB-5083 may be a useful treatment strategy to combat CB-5083 resistance.

Pair Name	Sulforaphane, Gefitinib
Phytochemical	Sulforaphane
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	SFN overcame T790M-mediated gefitinib resistance in vitro through EMT. Thus, a combination of gefitinib and SFN may be a beneficial treatment strategy for lung cancer patients with acquired resistance due to T790M mutation.

Pair Name	Sulforaphene, Photodynamic therapy
Phytochemical	Sulforaphene
Drug	Photodynamic therapy
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	This study could be useful in the improvement of therapies for human cervical and other types of cancers.

Pair Name	Tectochrysin, Cetuximab
Phytochemical	Tectochrysin
Drug	Cetuximab
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Our results indicate that combined therapy with lower concentration of cetuximab and tectochrysin could significantly enhance the cancer cell growth inhibitory effect through the inhibition of EGFR signaling.

Pair Name	Tetrahydrocurcumin, Celecoxib
Phytochemical	Tetrahydrocurcumin
Drug	Celecoxib
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	The combinational treatment effect of THC and celecoxib causing inhibition of tumor growth and tumor angiogenesis via down-regulation of VEGF, COX-2 and EGFR expression. However, this combined treatment did not show the synergistic effect on inhibiting the tumor growth and tumor angiogenesis in cervical cancer (CaSki)-implanted nude mice model.

Pair Name	Trigonelline, Cisplatin
Phytochemical	Trigonelline
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Our study demonstrated that Trigonelline blocks Nrf2 activation and its nuclear translocation via inhibition of EGFR signalling pathway. It has improved responsiveness of NSCLC cells for Cisplatin and Etoposide and could be a promising choice for lung cancer therapy. Toxicol In Vitro. 2021 Feb;70:105038. doi: 10.1016/j.tiv.2020.105038.

Pair Name	Tubeimoside I, Temozolomide
Phytochemical	Tubeimoside I
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	We first demonstrated that synergistic effects of TBMS1 and TMZ induced apoptosis in GBM cells through reducing MGMT expression and inhibiting the EGFR induced PI3K/Akt/mTOR/NF-κB signaling pathway. This study provides a rationale for combined application of TMZ and TBMS1 as a potential chemotherapeutic treatment for MGMT+ GBM patients.

Pair Name	Zerumbone, Gefitinib
Phytochemical	Zerumbone
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	Our study suggested that zerumbone combined with gefitinib could effectively inhibit lung cancer for multi-model therapies, including the inhibition of tumor growth, angiogenesis, induce cell apoptosis, and ferroptosis.

Pair Name	(20S)-Protopanaxatriol, EGFR-TKI
Phytochemical	(20S)-Protopanaxatriol
Drug	EGFR-TKI
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Phosphorylation
Result	Our findings uncover a link between lipid metabolic reprogramming and EGFR-TKI resistance, confirmed that combination target both EGFR and abnormal lipid metabolism maybe a promising therapy for EGFR-TKI resistance and highlighting the possibility of monitoring lipid accumulation in tumors for predicting drug resistance.

Pair Name	Curcumin, Lenvatinib
Phytochemical	Curcumin
Drug	Lenvatinib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	We report that Curcumin reverses Lenvatinib resistance in HCC, and that their combination has clinical application potential for adjunctive treatment in HCC.

Pair Name	Shikonin, Gefitinib
Phytochemical	Shikonin
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Epidermal growth factor receptor		Expression
Result	Shikonin-induced cell apoptosis is closely associated with ROS elevation in the cells. These findings indicate that Shikonin can be an effective small molecule treating gefitinib-resistant NSCLC.