Pair Name	Baicalein, Docetaxel
Phytochemical Name	Baicalein
Anticancer drug Name	Docetaxel
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Baicalein enhances the antitumor efficacy of docetaxel on nonsmall cell lung cancer in a β-catenin-dependent manner

Pair Name	Carnosic acid, Anti-PD-1 antibody
Phytochemical Name	Carnosic acid
Anticancer drug Name	Anti-PD-1 antibody
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	CA-NBF combined with anti-PD-1 have stronger immunomodulatory and anticancer effects without increasing biological toxicity.

Pair Name	Camptothecin, Doxorubicin
Phytochemical	Camptothecin
Drug	Doxorubicin
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Catenin beta-1		Expression
Result	Camptothecin-doxorubicin combinations showed synergistic antitumor acitivity.

Pair Name	Harmine, Paclitaxel
Phytochemical	Harmine
Drug	Paclitaxel
Disease Info	[ICD-11: 2B72.Z]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer

Pair Name	Piperlongumine, Doxorubicin
Phytochemical	Piperlongumine
Drug	Doxorubicin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Piperlongumine induces ROS mediated apoptosis by transcriptional regulation of SMAD4/P21/P53 genes and synergizes with doxorubicin in osteosarcoma cells

Pair Name	Piperlongumine, Paclitaxel
Phytochemical	Piperlongumine
Drug	Paclitaxel
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells

Pair Name	Tetrandrine, Cisplatin
Phytochemical	Tetrandrine
Drug	Cisplatin
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo

Pair Name	Puerarin, Cisplatin
Phytochemical	Puerarin
Drug	Cisplatin
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Taking these results together, we can draw the conclusion that the PUE enhances the anti-tumor effect of DDP on the drug-resistant A549 cancer in vivo and in vitro through activation of the Wnt signaling pathway.

Pair Name	Dihydroartemisinin, Capecitabine
Phytochemical	Dihydroartemisinin
Drug	Capecitabine
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	DHA in combination with Cap could be a novel therapeutic strategy for CRC with improved efficacy and reduced side effects.

Pair Name	Toosendanin, Paclitaxel
Phytochemical	Toosendanin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	The results suggest that combination of TSN and PTX is superior to PTX alone, suggesting that it may be a promising alternative adjuvant chemotherapy strategy for patients with TNBC, especially those with metastatic TNBC.

Pair Name	Furanodiene, Doxorubicin
Phytochemical	Furanodiene
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	These observations indicate that furanodiene is a potential agent that may be utilized to improve the anticancer efficacy of doxorubicin and overcome the risk of chemotherapy in highly metastatic breast cancer.

Pair Name	Tanshinone IIA, Doxorubicin
Phytochemical	Tanshinone IIA
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Tan II A could be used as a potential chemosensitizer in combination with Dox for breast cancer chemotherapy.

Pair Name	Thymoquinone, Fluorouracil
Phytochemical	Thymoquinone
Drug	Fluorouracil
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Our findings present the first report describing the in vivo enhancement effect of combined TQ and 5-FU against early stages of CRC; however, further studies are required to determine the value of this combination therapy in an advanced long-term model of CRC and also to realize its clinical potential.

Pair Name	Withaferin A, Fluorouracil
Phytochemical	Withaferin A
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Synergistic antitumor effect of 5-fluorouracil and withaferin-A induces endoplasmic reticulum stress-mediated autophagy and apoptosis in colorectal cancer cells

Pair Name	Curcumin, Pyridoxine
Phytochemical	Curcumin
Drug	Pyridoxine
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Phosphorylation
Result	C + B is superior to either agent alone in preventing obesity-promoted colorectal carcinogenesis. Augmented suppression of procancerous signaling pathways may be the means by which this augmentation occurs.

Pair Name	All-trans retinoic acid, Salinomycin
Phytochemical	All-trans-retinoic acid
Drug	Salinomycin
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	S+RA induced differentiation by β-catenin-inhibition-mediated up-regulation of C/EBPs and PU.1 and suppression of c-Myc. S+RA triggered apoptosis through β-catenin-inhibition-regulated ΔΨm collapse and caspase-3/7 activation. Taken together, our findings may provide novel therapeutic strategies for AML patients by targeting the WNT/β-catenin pathway.

Pair Name	Sulforaphane, Cisplatin
Phytochemical	Sulforaphane
Drug	Cisplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	The results of the current study suggests that CIS when supplemented with SFN, inhibits metastasis and stemness potential of TNBC cells by down regulating SIRTs-mediated EMT cascade. Overall this study affirms that, this novel combination could be a promising strategy against SIRT-mediated TNBC metastasis and CIS-resistance.

Pair Name	Sulforaphane, Metformin
Phytochemical	Sulforaphane
Drug	Metformin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Our data indicate that SLFN and MTFN can reduce cancer cell viability via both collaborative and differential effects and suggest that MTFN increases SLFN effectiveness by targeting common molecules/pathways downstream of HER2 and key for CSC signaling.

Pair Name	Gamma-Tocotrienol, SU11274
Phytochemical	Gamma-Tocotrienol
Drug	SU11274
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Catenin beta-1		Expression
Result	Suggest that combined γ-tocotrienol and Met inhibitor treatment may provide benefit in treatment of breast cancers characterized by aberrant Met activity.

Pair Name	Cordycepin, Temozolomide
Phytochemical	Cordycepin
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Cordycepin combined with temozolomide may down-regulate MYC through "MicroRNA in cancer, Proteoglycans in cancer, Pathways in cancer and PI3K-AKT signaling pathway", which in turn regulate the expression of MCL1, CTNNB1, MMP9, PDCD4, thus regulating cell proliferation, migration and apoptosis in glioblastoma.

Pair Name	Periplocin, TNF-related apoptosis inducing ligand
Phytochemical	Periplocin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B70.1]	Esophageal squamous cell carcinoma		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Activity
Result	Our data suggest that CPP and TRAIL could be further explored as potential therapeutic approach for esophageal cancer.

Pair Name	Periplocin, TNF-related apoptosis inducing ligand
Phytochemical	Periplocin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B70.1]	Esophageal squamous cell carcinoma		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Phosphorylation
Result	Our data suggest that CPP and TRAIL could be further explored as potential therapeutic approach for esophageal cancer.

Pair Name	Platycodin D, Cetuximab
Phytochemical	Platycodin D
Drug	Cetuximab
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Our findings provide a potential strategy to inhibit CRC metastasis during cetuximab therapy by addition of platycodin D.

Pair Name	Epibrassinolide, Etoposide
Phytochemical	Epibrassinolide
Drug	Etoposide
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Regulate Info	Down-regulation	Catenin beta-1		Expression
Result	Castasterone, a Plant Steroid Hormone, Affects Human Small-Cell Lung Cancer Cells and Reverses Multi-Drug Resistance