Pair Name	Chrysin, Paclitaxel
Phytochemical Name	Chrysin
Anticancer drug Name	Paclitaxel
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	CR exhibited the ability to reduce oxidative DNA damage, exert anti-apoptotic and anti-inflammatory properties, and mitigate the toxic effects of Pax-induced hepatorenal toxicity.

Pair Name	Juglone, Indomethacin
Phytochemical Name	Juglone
Anticancer drug Name	Indomethacin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	IND and JUG reduce the inflammatory activity and induce apoptotic cell death, while JUG effectively prevents IND induced gastric ulceration. These findings establish that a combination of IND + JUG may serve as a promising treatment regimen for colon cancer.

Pair Name	Paeonol, Epirubicin
Phytochemical Name	Paeonol
Anticancer drug Name	Epirubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	These findings suggest that combination of Paeonol and Epirubicin is potentially applicable for breast cancer treatment.

Pair Name	Paeonol, Methotrexate
Phytochemical Name	Paeonol
Anticancer drug Name	Methotrexate
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Paeonol protects against MTX-induced nephrotoxicity through antioxidant, anti-inflammatory, and antiapoptotic mechanisms and might potentiate MTX chemotherapeutic efficacy.

Pair Name	Amentoflavone, Cisplatin
Phytochemical	Amentoflavone
Drug	Cisplatin
Disease Info	[ICD-11: 2B66.0]	Oral squamous cell carcinoma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	Inactivation of NF-κB and induction of apoptosis through intrinsic caspase-dependent and independent apoptotic pathways are associated with amentoflavone enhanced anti-OSCC efficacy of cisplatin.

Pair Name	Amentoflavone, Sorafenib
Phytochemical	Amentoflavone
Drug	Sorafenib
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Phosphorylation
Result	Amentoflavone may sensitize OS to sorafenib treatment by inducing intrinsic and extrinsic apoptosis and inhibiting ERK/NF-κB signaling transduction.

Pair Name	Artepillin C, TNF-related apoptosis inducing ligand
Phytochemical	Artepillin C
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	The data demonstrate the important role of Brazilian green propolis and its bioactive compounds in prostate cancer chemoprevention through the enhancement of TRAIL-mediated apoptosis.

Pair Name	Astragaloside IV, Carboplatin
Phytochemical	Astragaloside IV
Drug	Carboplatin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Our results suggested that AgIV enhanced carboplatin sensitivity in prostate cancer cell lines by suppressing AKT/NF-κB signaling, thus suppressed epithelial-mesenchymal transition induced by carboplatin. Our findings provided a new mechanism for AgIV in overcoming drug resistance of platinum-based chemotherapy and suggested a potential combination therapy of AgIV and carboplatin in prostate cancer.

Pair Name	Baicalin, Fluorouracil
Phytochemical	Baicalin
Drug	Fluorouracil
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	BA is a promising preventive or adjuvant therapy in breast cancer treatment with 5-FU mainly via cooperative inhibition of inflammation, angiogenesis, and triggering apoptotic cell death.

Pair Name	Bergamottin, Simvastatin
Phytochemical	Bergamottin
Drug	Simvastatin
Disease Info	[ICD-11: 2A20.1]	Chronic myelogenous leukemia		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Discussion and conclusion Our results provide novel insight into the role of SV and BGM in potentially preventing and treating cancer through modulation of NF-κB signalling pathway and its regulated gene products.

Pair Name	Beta-Sitosterol, Gemcitabine
Phytochemical	Beta-Sitosterol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Phosphorylation
Result	β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling

Pair Name	Caffeic acid phenethyl ester, Bortezomib
Phytochemical	Caffeic acid phenethyl ester
Drug	Bortezomib
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	We think that our study, which is the first to demonstrate the in vitro and in vivo effectiveness of the.combined use of CAPE and bortezomib, will be a pioneer for future human applications of CAPE in MM.

Pair Name	Chebulagic acid, Doxorubicin
Phytochemical	Chebulagic acid
Drug	Doxorubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	The present study shows the efficacy of CA to overcome MDR-1 mediated drug resistance in HepG2 cells through COX-2 dependant modulation of MDR-1.

Pair Name	Cordycepin, Temozolomide
Phytochemical	Cordycepin
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Cordycepin combined with temozolomide may down-regulate MYC through "MicroRNA in cancer, Proteoglycans in cancer, Pathways in cancer and PI3K-AKT signaling pathway", which in turn regulate the expression of MCL1, CTNNB1, MMP9, PDCD4, thus regulating cell proliferation, migration and apoptosis in glioblastoma.

Pair Name	Costunolide, Osimertinib
Phytochemical	Costunolide
Drug	Osimertinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Phosphorylation
Result	The combination of osimertinib and costunolide showed synergistic or additive inhibitory effects on tumor growth in osimertinib-resistant cell lines and PDX model. Hence, this study highlights a potential therapeutic strategy for osimertinib-resistant patients through targeting of MEK1 and AKT1/2 by costunolide.

Pair Name	Curcumin, Paclitaxel
Phytochemical	Curcumin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	Curcumin reduces paclitaxel resistance in ovarian carcinoma cells by upregulating SNIP1 and inhibiting NFκB activity

Pair Name	Curcumin, TNF-related apoptosis inducing ligand
Phytochemical	Curcumin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	Combined treatment with curcumin and carboplatin inhibited tumor cell growth, migration, and invasion compared with either drug alone. The synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-kappaB via inhibition of the Akt/IKKalpha pathway and enhanced ERK1/2 activity

Pair Name	Curcumol, Cisplatin
Phytochemical	Curcumol
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	The findings may offer new thoughts that curcumol in combination with cisplatin might be a useful strategy for GC management.

Pair Name	Deoxyelephantopin, Gemcitabine
Phytochemical	Deoxyelephantopin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	It is possible that DET could be developed as a single agent or combined with conventional chemotherapy drugs to improve the treatment of pancreatic cancer.

Pair Name	Dihydroberberine, Sunitinib
Phytochemical	Dihydroberberine
Drug	Sunitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Phosphorylation
Result	DCS induced the expression of cell cycle signal molecules that are known to be affected by JNK and p38. The change of cell cycle, in turn, led to down-regulation of JNK and p38, and further reduced IL-1 secretion. Collectively, these findings highlight potential molecular mechanisms of DCS chemotherapeutic activity and suggest that DCS is an efficacious strategy in NSCLC therapy.

Pair Name	Emodin, Gemcitabine
Phytochemical	Emodin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	This study suggests that emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo, which may be via the downregulation of NF-κB expression, thus inhibiting the expression of XIAP.

Pair Name	Epigallocatechin gallate, Fluorouracil
Phytochemical	Epigallocatechin gallate
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	Our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU.

Pair Name	Eriocalyxin B, Gemcitabine
Phytochemical	Eriocalyxin B
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Phosphorylation
Result	Gem and EriB (or Isodon extract) taken together in combination regulated PDK1/AKT1/caspase and JNK signaling and promoted apoptosis synergistically, which may contribute to the much increased anti-proliferative activity compared to either agent alone.

Pair Name	Eurycomalactone, Cisplatin
Phytochemical	Eurycomalactone
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Phosphorylation
Result	This finding provides a rationale for the combined use of chemotherapy drugs with ECL to improve their efficacy in NSCLC treatment.

Pair Name	Flavokawain B, Daunorubicin
Phytochemical	Flavokawain B
Drug	Daunorubicin
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Up-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	A combination treatment of DNR and FKB may improve the anticancer effects of DNR in DNR-resistant acute myeloid leukemia.

Pair Name	Gamma-Tocotrienol, Capecitabine
Phytochemical	Gamma-Tocotrienol
Drug	Capecitabine
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Our findings suggest that γ-T3 inhibited the growth of human CRC and sensitised CRC to capecitabine by regulating proteins linked to tumourigenesis.

Pair Name	Gamma-Tocotrienol, Docetaxel
Phytochemical	Gamma-Tocotrienol
Drug	Docetaxel
Disease Info	[ICD-11: 2B66.Z]	Oral cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	These findings suggest that the combination treatment with these agents may provide enhanced therapeutic response in oral cancer patients, while avoiding the toxicity associated with high-dose β-tubulin stabilization monotherapy.

Pair Name	Gamma-Tocotrienol, Gemcitabine
Phytochemical	Gamma-Tocotrienol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Our findings suggest that γ-T3 can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing NF-κB-mediated inflammatory pathways linked to tumorigenesis.

Pair Name	Gamma-Tocotrienol, SU11274
Phytochemical	Gamma-Tocotrienol
Drug	SU11274
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Phosphorylation
Result	Suggest that combined γ-tocotrienol and Met inhibitor treatment may provide benefit in treatment of breast cancers characterized by aberrant Met activity.

Pair Name	Gedunin, Epalrestat
Phytochemical	Gedunin
Drug	Epalrestat
Disease Info	[ICD-11: 2B66.Z]	Oral cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Our results provide compelling evidence that the combination of gedunin and epalrestat modulates expression of key oncogenic signalling kinases and transcription factors primarily by influencing phosphorylation and subcellular localisation. AR inhibitors such as gedunin and epalrestat are novel candidate agents for cancer prevention and therapy.

Pair Name	Ginger extract, Doxorubicin
Phytochemical	Ginger extract
Drug	Doxorubicin
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	AMPK pathway and cyclin D1 gene expression could be a molecular therapeutic target for the anticancer effect of GE in mice bearing SEC. Combining GE and DOX revealed a greater efficacy as anticancer therapeutic regimen.

Pair Name	Ginsenoside Rh2, Gemcitabine
Phytochemical	Ginsenoside Rh2
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Rh2 activation of DCs may remodel the cold TIME and optimize GEM chemotherapy for future therapeutic use.

Pair Name	Guggulsterone, Gemcitabine
Phytochemical	Guggulsterone
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10.0]	Pancreatic ductal adenocarcinoma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	The combination of guggulsterone to gemcitabine enhanced antitumor efficacy through apoptosis induction by suppressing Akt and nuclear factor KappaB activity and by modulating apoptosis-related protein expression in pancreatic cancer

Pair Name	Harmine, Paclitaxel
Phytochemical	Harmine
Drug	Paclitaxel
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer

Pair Name	Hispidin, Gemcitabine
Phytochemical	Hispidin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Hispidin might be a novel chemosensitizer for gemcitabine and a potential synergistic agent for increasing the therapeutic index of gemcitabine as a treatment for pancreatic cancer.

Pair Name	Icariin, Fluorouracil
Phytochemical	Icariin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	We suggest that combination of icariin with 5-FU might offer a therapeutic benefit to the patients with CRC; however, further studies are required to ascertain this proposition.

Pair Name	Icariin, Gemcitabine
Phytochemical	Icariin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C94]	Bladder cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	Icariin, by suppressing NF-κB activity, exerts antitumor activity, and potentiates the antitumor activity of gemcitabine in gallbladder cancer. Combined administration of gemcitabine and icariin may offer a better therapeutic option for the patients with gallbladder cancer.

Pair Name	Juglone, Indomethacin
Phytochemical	Juglone
Drug	Indomethacin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	A combination of both was shown to be more effective, suggesting that juglone may be considered for therapeutic intervention of colon cancer.

Pair Name	Luteolin, Erlotinib
Phytochemical	Luteolin
Drug	Erlotinib
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Phosphorylation
Result	These findings suggest that combining luteolin with erlotinib offers a potential treatment strategy for glioblastoma multiforme IV.

Pair Name	Luteolin, SMC3
Phytochemical	Luteolin
Drug	SMC3
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	The results suggest that combination of SMC3 and luteolin is an effective approach for improving the anticancer value of SMC3, which has implications in cancer prevention and therapy.

Pair Name	Lycopene, Cisplatin
Phytochemical	Lycopene
Drug	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Lycopene increases the sensitization of cervical cancer cells to cisplatin via inhibition of cell viability, up-regulation of Bax expression, and down-regulation of Bcl-2 expression. Furthermore, the anticancer effect of lycopene might be also associated with suppression of NF-κB-mediated inflammatory responses, and modulation of Nrf2-mediated oxidative stress. The results of the present study suggest that lycopene and concurrent cisplatin chemotherapy might have a role in improving the treatment of cervical cancer.

Pair Name	Mangiferin, Doxorubicin
Phytochemical	Mangiferin
Drug	Doxorubicin
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Our findings suggest that the combination of mangiferin and an anticancer drug could be used as a new regime for the treatment of MM.

Pair Name	Maslinic acid, Gemcitabine
Phytochemical	Maslinic acid
Drug	Gemcitabine
Disease Info	[ICD-11: 2C94]	Bladder cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	The results suggest that MA potentiates the antitumor effects of GEM in human GBC cell lines by suppressing the activation of NF-κB and its dowstream gene products, which are involved in survival signaling.

Pair Name	Naringenin, Diosmin
Phytochemical	Naringenin
Drug	Diosmin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Diosmin in combination with naringenin enhances apoptosis in colon cancer cells

Pair Name	Neferine, Cisplatin
Phytochemical	Neferine
Drug	Cisplatin
Disease Info	[ICD-11: 2C90.Z]	Renal carcinoma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	Neferine increases sensitivities to multiple anticancer drugs via downregulation of Bcl-2 expression in renal cancer cells

Pair Name	Nimbolide, Docetaxel
Phytochemical	Nimbolide
Drug	Docetaxel
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	The combination of NL and DTX significantly reduced the DNA binding ability of NF-κB in both cell types. NL significantly enhanced the antitumor effect of DTX and reduced metastases in orthotopic models of prostate cancer. NL abolishes DTX-induced-NF-κB activation to counteract cell proliferation, tumor growth, and metastasis in the prostate cancer models.

Pair Name	Nobiletin, Bicalutamide
Phytochemical	Nobiletin
Drug	Bicalutamide
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	NBT and BCT combination reduced key cellular signaling regulators including: p-Erk/Erk, p-STAT3/STAT3 and NF-κB. Overall, these results suggest that NBT combination with BCT may be an effective treatment for prostate cancer.

Pair Name	Noscapine, Cisplatin
Phytochemical	Noscapine
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Noscapine Increases the Sensitivity of Drug-Resistant Ovarian Cancer Cell Line SKOV3/DDP to Cisplatin by Regulating Cell Cycle and Activating Apoptotic Pathways

Pair Name	Obovatol, Docetaxel
Phytochemical	Obovatol
Drug	Docetaxel
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	These results indicate that obovatol augments cell growth inhibition by chemotherapeutics through inactivation of NF-kappaB and suggest that obovatol may have therapeutic advantages in the combination treatment with other chemotherapeutics.

Pair Name	Oleuropein, Doxorubicin
Phytochemical	Oleuropein
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	The key findings clearly indicate the synergistic efficacy of DOX with natural and nontoxic OL against breast tumor xenografts.

Pair Name	Oridonin, Arsenic oxide (As2O3)
Phytochemical	Oridonin
Drug	Arsenic oxide (As2O3)
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	The combination treatment induced ROS-dependent decrease in mitochondrial membrane potential (MMP) decrease, and relocation of Bax and cytochrome C. Besides, oridonin dramatically increased the intracellular Ca2+ overload triggered by As2O3. Furthermore, the co-treatment of oridonin and As2O3 induced ROS-mediated down-regulation of Akt and XIAP, and inhibition of NF-κB activation. The two drug combination enhanced tumor suppression activity in murine HCC model compared with single agent treatment in vivo.

Pair Name	Parthenolide, Balsalazide
Phytochemical	Parthenolide
Drug	Balsalazide
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	These results demonstrate that parthenolide potentiates the efficacy of balsalazide through synergistic inhibition of NF-κB activation and the combination of dual agents prevents colon carcinogenesis from chronic inflammation.

Pair Name	Piperlongumine, Doxorubicin
Phytochemical	Piperlongumine
Drug	Doxorubicin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Piperlongumine induces ROS mediated apoptosis by transcriptional regulation of SMAD4/P21/P53 genes and synergizes with doxorubicin in osteosarcoma cells

Pair Name	Rosmarinic acid, Paclitaxel
Phytochemical	Rosmarinic acid
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Rosmarinic acid exerted chemo-preventive and therapeutic potential alone or in combination with Paclitaxel. Moreover, rosmarinic acid targets numerous signaling pathways associated with breast cancer.

Pair Name	Saikosaponin B1, Etoposide
Phytochemical	Saikosaponin B1
Drug	Etoposide
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	We conclude Saikosaponin B can be an attractive adjuvant for enhancing the clinical effect of cancer chemotherapy.

Pair Name	Shogaol, Gemcitabine
Phytochemical	Shogaol
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10.0]	Pancreatic ductal adenocarcinoma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	Our results suggest that 6-shogaol can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing of TLR4/NF-κB-mediated inflammatory pathways linked to tumorigenesis.

Pair Name	Sulforaphane, CB-5083
Phytochemical	Sulforaphane
Drug	CB-5083
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	The combination of Sulforaphane and CB-5083 may be a useful treatment strategy to combat CB-5083 resistance.

Pair Name	Tectochrysin, Cetuximab
Phytochemical	Tectochrysin
Drug	Cetuximab
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	Our results indicate that combined therapy with lower concentration of cetuximab and tectochrysin could significantly enhance the cancer cell growth inhibitory effect through the inhibition of EGFR signaling.

Pair Name	Tectorigenin, Paclitaxel
Phytochemical	Tectorigenin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	These data suggest that tectorigenin could sensitize paclitaxel-resistant human ovarian cancer cells through inactivation of the Akt/IKK/IκB/NFκB signaling pathway, and promise a new intervention to chemosensitize paclitaxel-induced cytotoxicity in ovarian cancer.

Pair Name	Thymoquinone, Cisplatin
Phytochemical	Thymoquinone
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Thymoquinone combined with cisplatin showed synergistic anticancer activity by down-regulating NF-kappaB

Pair Name	Thymoquinone, Fluorouracil
Phytochemical	Thymoquinone
Drug	Fluorouracil
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Our findings present the first report describing the in vivo enhancement effect of combined TQ and 5-FU against early stages of CRC; however, further studies are required to determine the value of this combination therapy in an advanced long-term model of CRC and also to realize its clinical potential.

Pair Name	Tiliroside, Anti-MUC1 antibody
Phytochemical	Tiliroside
Drug	Anti-MUC1 antibody
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	The combined action of anti-MUC1 and tiliroside was more effective in comparison with monotherapy in the case of C1GalT1, ST3GalT1, FUT4, Gal-3, NF-κB, Akt mRNAs, and Tn antigen, as well as sialyl T antigen expression. The results of our study indicate that applied combined therapy may be a promising anti-gastric cancer strategy.

Pair Name	Tubeimoside I, Temozolomide
Phytochemical	Tubeimoside I
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Phosphorylation
Result	We first demonstrated that synergistic effects of TBMS1 and TMZ induced apoptosis in GBM cells through reducing MGMT expression and inhibiting the EGFR induced PI3K/Akt/mTOR/NF-κB signaling pathway. This study provides a rationale for combined application of TMZ and TBMS1 as a potential chemotherapeutic treatment for MGMT+ GBM patients.

Pair Name	Aloe emodin, Temozolomide
Phytochemical	Aloe emodin
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	These convincing results suggest that AE could be a natural adjuvant agent to potentiate the effects of traditional drugs (TMZ) and overcome drug resistance in glioblastoma cells.

Pair Name	Oleanolic Acid, Cisplatin
Phytochemical	Oleanolic Acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Phosphorylation
Result	OLO-2 treatment also exhibited up to 4.6-fold selectivity against human lung adenocarcinoma cells. Taken together, the results of the present study shed light on the drug resistance-reversing effects of OLO-2 in lung cancer cells.

Pair Name	Parthenolide, Temozolomide
Phytochemical	Parthenolide
Drug	Temozolomide
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Activity
Result	These findings suggest that NF-κB is a potential target for inducing cell death in gliomas. A targeted combination strategy in which the response to TMZ is synergistically enhanced by the addition of parthenolide which may be useful, especially in chemoresistant gliomas with high MGMT expression.

Pair Name	Troxerutin, Fluorouracil
Phytochemical	Troxerutin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Down-regulation	Nuclear factor NF-kappa-B p105		Expression
Result	Our data indicated a novel therapeutic strategy to potentiate 5-FU-induced anti-tumor effect in gastric cancer cells with resistance to 5-FU by TXN through suppression of p-STAT3/NF-κB (p65 and p50) and Bcl-2.