Pair Name	Artesunate, Fluorouracil
Phytochemical Name	Artesunate
Anticancer drug Name	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Expression
Result	Our findings point to the crucial treatment effect of Arte on inflammation, intestinal cell senescence, and CRC cell proliferation and offer a new option for CRC treatment.

Pair Name	Calycosin-7-O-β-D-glucoside, Cisplatin
Phytochemical Name	Calycosin-7-O-β-D-glucoside
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	CG significantly increases the CDDP-induced apoptosis of the SK-OV-3 cells through the p53 pathway at the cellular level. In addition, using the drugs in combination reduces the toxicity and side effects caused by using CDDP alone.

Pair Name	Curcumin, Temozolomide
Phytochemical Name	Curcumin
Anticancer drug Name	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	We showed for the first time that exosomes released from drug-treated U87 cells could be a new therapeutic approach in glioblastoma, and could reduce the side effects produced by drugs alone. This concept needs to be further examined in animal models before clinical trials could be considered.

Pair Name	Deoxyelephantopin, Cisplatin
Phytochemical Name	Deoxyelephantopin
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The CP and DET combination may be an effective intervention for melanoma with reduced side effects.

Pair Name	Kuromanin chloride, Cisplatin
Phytochemical Name	Kuromanin chloride
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Activity
Result	Cyanidin-3-O-glucoside and cisplatin inhibit proliferation and downregulate the PI3K/AKT/mTOR pathway in cervical cancer cells

Pair Name	Lupeol, Sorafenib
Phytochemical Name	Lupeol
Anticancer drug Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Expression
Result	Implication of Lupeol in compensating Sorafenib-induced perturbations of redox homeostasis: A preclinical study in mouse model

Pair Name	Magnoflorine, Doxorubicin
Phytochemical Name	Magnoflorine
Anticancer drug Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways

Pair Name	Mahanine, Fluorouracil
Phytochemical Name	Mahanine
Anticancer drug Name	Fluorouracil
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma.

Pair Name	Oleanolic Acid, Doxorubicin
Phytochemical Name	Oleanolic Acid
Anticancer drug Name	Doxorubicin
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	This approach may increase the efficiency of chemotherapy and reduce unintended side effects by lowering the prescribed dose of DOX.

Pair Name	Resveratrol, Cisplatin
Phytochemical Name	Resveratrol
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest

Pair Name	Usnic acid, Bleomycin
Phytochemical Name	Usnic acid
Anticancer drug Name	Bleomycin
Disease Info	[ICD-11: 2F94]	Ascitic tumor		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin

Pair Name	[6]-Gingerol, Cisplatin
Phytochemical	[6]-Gingerol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The findings of the present study demonstrated that the cisplatin and 6-gingerol combination is more effective in inducing apoptosis and suppressing the angiogenesis of ovarian cancer cells than using each drug alone.

Pair Name	[6]-Gingerol, Paclitaxel
Phytochemical	[6]-Gingerol
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Anticancer Efficacy of 6-Gingerol with Paclitaxel against Wild Type of Human Breast Adenocarcinoma

Pair Name	2,3,5,6-Tetramethylpyrazine, Doxorubicin
Phytochemical	2,3,5,6-Tetramethylpyrazine
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	DLJ14 and Adr combination treatment may inhibit proliferation of Adr-resistant human breast cancer cells through inhibition of the EGFR/PI3K/Akt survival pathway and induction of apoptosis via the mitochondrial-mediated apoptosis pathway.

Pair Name	Acteoside, Sorafenib
Phytochemical	Acteoside
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Acteoside exerts an antitumor effect possibly through its up-regulation of p53 levels as well as inhibition of KLK expression and angiogenesis. Acteoside could be useful as an adjunct in the treatment of advanced HCC in the clinic.

Pair Name	Acteoside, Temozolomide
Phytochemical	Acteoside
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	It was also determined that TMZ + acteoside induced apoptosis and autophagy through the mitogen‑activated protein kinase signaling pathway. These findings suggest that acteoside has beneficial effects on TMZ‑based glioblastoma therapy.

Pair Name	Amygdalin, Cisplatin
Phytochemical	Amygdalin
Drug	Cisplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Phosphorylation
Result	Our present findings suggest that amygdalin has chemo-modulatory effect when used in co-treatment with cisplatin and is able to protect normal breast cells as well as the fibroblasts during chemotherapy treatment, indicating a strong selective chemoprotective ability and may contribute to a better quality of life for cancer patients.

Pair Name	Anacardic Acid, Fluorouracil
Phytochemical	Anacardic Acid
Drug	Fluorouracil
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	Our data suggests that Anacardic Acid might be a promising complementary supplement to slow the initiation or progression of pancreatic cancer.

Pair Name	Arachidin-1, Paclitaxel
Phytochemical	Arachidin-1
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	A-1 in combination with Pac inhibited cell proliferation, induced apoptosis through mitochondrial oxidative stress, and reduced TNBC spheroid growth. These findings underscore the impactful effects of the prenylated stilbenoid A-1 as a novel adjuvant for Pac chemotherapy in TNBC treatment.

Pair Name	Artesunate, Cisplatin
Phytochemical	Artesunate
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	ART exhibited significant anti-tumor effect on A549 cells and this efficiency could be enhanced by combination with CIS

Pair Name	Astaxanthin, Cytarabine
Phytochemical	Astaxanthin
Drug	Cytarabine
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Co-treatment of ASX and Ara-C has synergism effects on apoptosis pathways, cell proliferation inhibition, and decreased inflammation.

Pair Name	Baicalin, Fluorouracil
Phytochemical	Baicalin
Drug	Fluorouracil
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	BA is a promising preventive or adjuvant therapy in breast cancer treatment with 5-FU mainly via cooperative inhibition of inflammation, angiogenesis, and triggering apoptotic cell death.

Pair Name	Berbamine, Arcyriaflavin A
Phytochemical	Berbamine
Drug	Arcyriaflavin A
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our findings suggest that a novel combination therapy involving berbamine and ArcA could effectively eradicate glioblastoma stem-like cells.

Pair Name	Beta-Elemene, Bortezomib
Phytochemical	Beta-Elemene
Drug	Bortezomib
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Expression
Result	Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism

Pair Name	Beta-Elemene, Etoposide
Phytochemical	Beta-Elemene
Drug	Etoposide
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	These results suggest that the combination of β-elemene and VP-16 may be a promising therapeutic option for lung cancer.

Pair Name	Biochanin A, Temozolomide
Phytochemical	Biochanin A
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	Chanin A significantly enhanced the anticancer efficacy of temozolomide in GBM cells.

Pair Name	Bixin, Cisplatin
Phytochemical	Bixin
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The administration of bixin or fucoxanthin decreases the expression of ABCC1 and ABCC2. Both carotenoids, either alone or in combination with cisplatin, upregulated p53 gene expression indicating the mechanism of proliferation inhibition and apoptosis occurs via the p53 caspase-independent pathway.

Pair Name	Bufalin, Hydroxycamptothecin
Phytochemical	Bufalin
Drug	Hydroxycamptothecin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The present study suggested that the combination of bufalin and hydroxycampothecin improved the inhibitory effects of both drugs on CRPC tumors in vivo, potentially via the regulation of the PI3K/AKT/GSK-3β and p53-dependent apoptosis signaling pathways.

Pair Name	Caffeic acid phenethyl ester, Cisplatin
Phytochemical	Caffeic acid phenethyl ester
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	This study reveals the therapeutic potential of CAPE in cisplatin-resistant ovarian tumors as well as in tumors expressing USP8.

Pair Name	Capsaicin, 3,3'-diindolylmethane
Phytochemical	Capsaicin
Drug	3,3'-diindolylmethane
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The present study suggests capsaicin and DIM work synergistically to inhibit cell proliferation and induce apoptosis in colorectal cancer through modulating transcriptional activity of NF-κB, p53, and target genes associated with apoptosis.

Pair Name	Carnosic acid, Tamoxifen
Phytochemical	Carnosic acid
Drug	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our study supplies a novel therapeutic strategy to induce apoptosis for suppressing breast cancer, which was relied on Caspase-3/TRAIL activation.

Pair Name	Chrysin, Cisplatin
Phytochemical	Chrysin
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our results suggest that combination of chrysin and cisplatin is a promising strategy for chemotherapy of human cancers that are resistant to cisplatin.

Pair Name	Curcumin, Arsenic oxide (As2O3)
Phytochemical	Curcumin
Drug	Arsenic oxide (As2O3)
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The antitumor effects of combination therapy with As2O3 and Curcumin have been displayed on prostate cancer cell lines (LNCaP and PC3), which probably originates from their potential to induce apoptosis and inhibit the growth of prostate cancer cells simultaneously.

Pair Name	Curcumin, Arsenic trioxide
Phytochemical	Curcumin
Drug	Arsenic trioxide
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our results suggested that curcumin and As2O3 combination therapy exerts more significant anti-leukemia effects in the treatment of AML than curcumin or As2O3 monotherapy by up-regulating p53 pathway and down-regulating the JAK2/STAT3 pathway.

Pair Name	Curcumin, Binimetinib
Phytochemical	Curcumin
Drug	Binimetinib
Disease Info	[ICD-11: 2C30]	Melanoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our data demonstrates that curcumin exerts significant synergistic anticancer effects on MM cells by inducing ROS and necroptosis when combined with binimetinib. Therefore, a strategy of adding curcumin to conventional anticancer agents holds promise for treating MM.

Pair Name	Curcumin, Carfilzomib
Phytochemical	Curcumin
Drug	Carfilzomib
Disease Info	[ICD-11: 2A83.1]	Plasma cell myeloma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Curcumin significantly ameliorates CFZ cytotoxic effect. Induction of p53/p21 axis and G0/G1 cell cycle arrest were more pronounced for the CFZ-curcumin combination

Pair Name	Curcumin, Dactolisib
Phytochemical	Curcumin
Drug	Dactolisib
Disease Info	[ICD-11: 2D11]	Neuroblastoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Synergistic anti-proliferative and apoptotic effect of NVP-BEZ235 and curcumin on human SH-SY5Y neuroblastoma cells.

Pair Name	Curcumin, Melphalan
Phytochemical	Curcumin
Drug	Melphalan
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Expression
Result	Curcumin and melphalan cotreatment induces cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells

Pair Name	Curcumin, TNF-related apoptosis inducing ligand
Phytochemical	Curcumin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Combined treatment with curcumin and carboplatin inhibited tumor cell growth, migration, and invasion compared with either drug alone. The synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-kappaB via inhibition of the Akt/IKKalpha pathway and enhanced ERK1/2 activity

Pair Name	Damnacanthal, Doxorubicin
Phytochemical	Damnacanthal
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin against Human Breast Cancer MCF-7 Cells in Vitro

Pair Name	Emodin, Doxorubicin
Phytochemical	Emodin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Emodin Interferes With AKT1-Mediated DNA Damage and Decreases Resistance of Breast Cancer Cells to Doxorubicin

Pair Name	Fucoxanthin, Doxorubicin
Phytochemical	Fucoxanthin
Drug	Doxorubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Activity
Result	The carotenoid fucoxanthin can sensitize multidrug resistant cancer cells to doxorubicin via induction of apoptosis, inhibition of multidrug resistance proteins and metabolic enzymes

Pair Name	Gambogic acid, NaI*131
Phytochemical	Gambogic acid
Drug	NaI*131
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Expression
Result	The two drugs appear to have a synergistic effect on apoptosis of A549/DDP cells.

Pair Name	Genipin, Oxaliplatin
Phytochemical	Genipin
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	We showed that genipin increases the oxaliplatin-induced cell death via p53-DRAM autophagy, we suggest that genipin is a sensitizer of oxaliplatin.

Pair Name	Ginger extract, Doxorubicin
Phytochemical	Ginger extract
Drug	Doxorubicin
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	AMPK pathway and cyclin D1 gene expression could be a molecular therapeutic target for the anticancer effect of GE in mice bearing SEC. Combining GE and DOX revealed a greater efficacy as anticancer therapeutic regimen.

Pair Name	GingerenoneA, Dexamethasone
Phytochemical	GingerenoneA
Drug	Dexamethasone
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our findings may provide novel strategies for therapeutic intervention to ameliorate pALL outcomes.

Pair Name	Ginsenoside Rg1, Doxorubicin
Phytochemical	Ginsenoside Rg1
Drug	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The present results support the chemosensitizing property of ginsenoside Rg1 in triple-negative breast cancer cell lines.

Pair Name	Gossypol, BRD4770
Phytochemical	Gossypol
Drug	BRD4770
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	The combination of gossypol and BRD4770 increased LC3-II levels and the autophagosome number in PANC-1 cells, and the compound combination appears to act in a BNIP3 (B-cell lymphoma 2 19-kDa interacting protein)-dependent manner, suggesting that these compounds act together to induce autophagy-related cell death in pancreatic cancer cells.

Pair Name	Gossypol, Ponatinib
Phytochemical	Gossypol
Drug	Ponatinib
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Gossypol could be used as an adjuvant medication for ponatinib in cancer treatment, possibly leading to successful dose reductions and fewer side effects; however, further research is needed before a clinical application could be feasible.

Pair Name	Gossypol, Zoledronic acid
Phytochemical	Gossypol
Drug	Zoledronic acid
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Expression
Result	GP significantly enhances the anti-tumor activity of ZA in hormone- and drug-resistant prostate cancer cells by targeting many pivotal apoptosis-related proteins.

Pair Name	Gynostemma Extract, Fluorouracil
Phytochemical	Gynostemma Extract
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	Gypenosides Synergistically Enhances the Anti-Tumor Effect of 5-Fluorouracil on Colorectal Cancer In Vitro and In Vivo: A Role for Oxidative Stress-Mediated DNA Damage and p53 Activation

Pair Name	Harmine, Paclitaxel
Phytochemical	Harmine
Drug	Paclitaxel
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer

Pair Name	Hederagenin, Cisplatin
Phytochemical	Hederagenin
Drug	Cisplatin
Disease Info	Head and neck cancer
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	Hederagenin effectively targets cisplatin-resistant HNC cells in vitro and in vivo. Consistent with its effects in other types of cancer, hederagenin markedly induces apoptosis in HNC cells by activating the mitochondria-driven intrinsic apoptotic pathway. We demonstrated that the apoptosis-inducing effects of hederagenin are mediated by the inhibition of the Nrf2-ARE antioxidant pathway.

Pair Name	Hesperetin, Capecitabine
Phytochemical	Hesperetin
Drug	Capecitabine
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	It can be suggested that both HES and CAP, singly or in combination, have the potential to exert chemopreventive effects against DMH-induced colon carcinogenesis via the suppression of oxidative stress, the stimulation of the antioxidant defense system, the attenuation of inflammatory effects, the reduction in cell proliferation and the enhancement of apoptosis.

Pair Name	Hesperetin, Capecitabine
Phytochemical	Hesperetin
Drug	Capecitabine
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	It can be suggested that both HES and CAP, singly or in combination, have the potential to exert chemopreventive effects against DMH-induced colon carcinogenesis via the suppression of oxidative stress, the stimulation of the antioxidant defense system, the attenuation of inflammatory effects, the reduction in cell proliferation and the enhancement of apoptosis.

Pair Name	Hispidin, Gemcitabine
Phytochemical	Hispidin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Expression
Result	Hispidin might be a novel chemosensitizer for gemcitabine and a potential synergistic agent for increasing the therapeutic index of gemcitabine as a treatment for pancreatic cancer.

Pair Name	Homoharringtonine, Cisplatin
Phytochemical	Homoharringtonine
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Expression
Result	Combinatorial treatment of ovarian cancer cells with harringtonine and cisplatin results in increased cisplatin-DNA adducts

Pair Name	Homoharringtonine, Suberoylanilide hydroxamic acid (SAHA)
Phytochemical	Homoharringtonine
Drug	Suberoylanilide hydroxamic acid (SAHA)
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The synergistic effect between HHT and SAHA was blocked partially using a specific anti‑TRAIL antibody. The combination therapy was also found to significantly inhibit the growth of leukemia xenografts in vivo with enhanced apoptosis. These results indicate that, by regulating the induction of TRAIL and activation of the TRAIL apoptotic pathway, it is possible to administer HHT at low concentrations in combination with SAHA as an effective therapeutic approach for the treatment of AML.

Pair Name	Licochalcone A, Fluorouracil
Phytochemical	Licochalcone A
Drug	Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	LCA alone or in combination with 5-FU may have significant anticancer effects on gastric cancer cells

Pair Name	Luteolin, Cisplatin
Phytochemical	Luteolin
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	These findings indicate the anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cells and luteolin may be a promising candidate agent used in the treatment of gastric cancer.

Pair Name	Luteolin, Fluorouracil
Phytochemical	Luteolin
Drug	Fluorouracil
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Current results proved the antitumor therapeutic effects of luteolin alone or combined with 5-FU as a novel strategy for cancer therapy.

Pair Name	Luteolin, Oxaliplatin
Phytochemical	Luteolin
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Luteolin can induce p53-mediated apoptosis regardless of oxaliplatin treatment and may eliminate oxaliplatin-resistant p53-null colorectal cells

Pair Name	Mangiferin, Doxorubicin
Phytochemical	Mangiferin
Drug	Doxorubicin
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our findings suggest that the combination of mangiferin and an anticancer drug could be used as a new regime for the treatment of MM.

Pair Name	Morin Hydrate, Cisplatin
Phytochemical	Morin Hydrate
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our findings indicate that CP-Mh in combination served as a prominent regulator of autophagy and significant inducer of apoptosis that maintains a homeostatic balance towards HepG2 cells and the subcutaneous tumor model.

Pair Name	Morin, MST312
Phytochemical	Morin
Drug	MST312
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	Our study suggests that novel targeted-therapy can be implemented by using flavonoid morin and telomerase inhibitor MST‑312 for improved cancer prognosis.

Pair Name	Narciclasine, Tamoxifen
Phytochemical	Narciclasine
Drug	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our findings successfully highlight the STAT3 as the direct therapeutic target of Nar in ER-positive breast cancer cells, especially, Nar leaded STAT3 degradation as a promising strategy for the tamoxifen-resistant breast cancer treatment.

Pair Name	Naringenin, AMG-951
Phytochemical	Naringenin
Drug	AMG-951
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The present study provides a novel therapeutic strategy for glioma by potentiating APO2L-induced apoptosis via the combination with NG in glioma tumor cells.

Pair Name	Naringenin, Diosmin
Phytochemical	Naringenin
Drug	Diosmin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Diosmin in combination with naringenin enhances apoptosis in colon cancer cells

Pair Name	Noscapine, Cisplatin
Phytochemical	Noscapine
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our results suggest that Nos enhanced the anticancer activity of Cis in an additive to synergistic manner by activating multiple signaling pathways including apoptosis. These findings suggest potential benefit for use of Nos and Cis combination in treatment of lung cancer.

Pair Name	Noscapine, Gemcitabine
Phytochemical	Noscapine
Drug	Gemcitabine
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Nos potentiated the anticancer activity of Gem in an additive to synergistic manner against lung cancer via antiangiogenic and apoptotic pathways. These findings suggest potential benefit for use of NGC chemotherapy for treatment of lung cancer.

Pair Name	Oleuropein, Cisplatin
Phytochemical	Oleuropein
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	These data revealed that oleuropein regulated the expression of the above-mentioned miRNAs in ovarian cancer cells, which potentially resulted in apoptosis induction, cell proliferation inhibition, and cisplatin resistance decline in ovarian cancer cells. To confirm the results of this study, it is suggested that similar experiments be performed in animal models of ovarian cancer.

Pair Name	Oridonin, Venetoclax
Phytochemical	Oridonin
Drug	Venetoclax
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Oridonin and venetoclax synergistically promote AML cell apoptosis by inhibiting AKT signaling.

Pair Name	Oroxylin A, Fluorouracil
Phytochemical	Oroxylin A
Drug	Fluorouracil
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The anti-hepatocellular carcinoma effects in vitro and in vivo of 5-FU and oroxylin A combinations were synergistic and oroxylin A increased the sensitivity of HepG2 cells to 5-FU by modulating the metabolic enzymes of 5-FU and apoptotic-related proteins

Pair Name	Osthol, Lobaplatin
Phytochemical	Osthol
Drug	Lobaplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	OST enhanced the apoptosis-mediated growth inhibitory effect of lobaplatin on breast cancer cells and has potential for the treatment of breast cancer in the future.

Pair Name	Parthenolide, Balsalazide
Phytochemical	Parthenolide
Drug	Balsalazide
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	These results demonstrate that parthenolide potentiates the efficacy of balsalazide through synergistic inhibition of NF-κB activation and the combination of dual agents prevents colon carcinogenesis from chronic inflammation.

Pair Name	Patchouli alcohol, Vincristine
Phytochemical	Patchouli alcohol
Drug	Vincristine
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Patchouli alcohol induces G0 /G1 cell cycle arrest and apoptosis in vincristine-resistant non-small cell lung cancer through ROS-mediated DNA damage

Pair Name	Piperlongumine, Doxorubicin
Phytochemical	Piperlongumine
Drug	Doxorubicin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Piperlongumine induces ROS mediated apoptosis by transcriptional regulation of SMAD4/P21/P53 genes and synergizes with doxorubicin in osteosarcoma cells

Pair Name	Piperlongumine, Paclitaxel
Phytochemical	Piperlongumine
Drug	Paclitaxel
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells

Pair Name	Polyphyllin I, Cisplatin
Phytochemical	Polyphyllin I
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Expression
Result	The results from the present study demonstrated that PPI and PPVII may function as chemosensitizers by enhancing apoptosis via the p53 pathway, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis, and the combination with DDP may be a promising strategy for the development of new therapeutic agents.

Pair Name	Pristimerin, Gemcitabine
Phytochemical	Pristimerin
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10.0]	Pancreatic ductal adenocarcinoma		Investigative
Regulate Info	Down-regulation	Cellular tumor antigen p53		Expression
Result	These results show that pristimerin acts as a naturally occurring inhibitor of RSR, and a novel therapeutic strategy of combining pristimerin and gemcitabine deserves further detailed investigation in PC models in vivo.

Pair Name	Raddeanin A, Cisplatin
Phytochemical	Raddeanin A
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Synergy of Raddeanin A and cisplatin induced therapeutic effect enhancement in human hepatocellular carcinoma

Pair Name	Resveratrol, ABT-737
Phytochemical	Resveratrol
Drug	ABT-737
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The obtained data indicate that the combination of ABT-737 and resveratrol is a promising approach for acute lymphoblastic leukemia treatment that should be further explored.

Pair Name	Resveratrol, Temozolomide
Phytochemical	Resveratrol
Drug	Temozolomide
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	TMZ in combination with resveratrol remarkably increased reactive oxygen species (ROS) production, which serves as an upstream signal for AMP-activated protein kinase (AMPK) activation. Subsequently, activated AMPK inhibited mTOR signaling and downregulated antiapoptosis protein Bcl-2, which was contributed to the additive antiproliferation effects of combination treatment. In an orthotopic xenograft model of GBM, TMZ plus resveratrol treatment significantly reduced the volume of tumor, which was confirmed by decreased expression of Ki-67, a marker of proliferation index

Pair Name	Rhizoma Paridis saponins, Sorafenib
Phytochemical	Rhizoma Paridis saponins
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	All of that provided possibility to overcome the intolerance of sorafenib by drug compatibility through protection against mitochondria damage, inhibition of anaerobic glycolysis and suppression of lipid synthesis based on PI3K/Akt/mTOR pathway.

Pair Name	Rosmarinic acid, Anti-MUC1 antibody
Phytochemical	Rosmarinic acid
Drug	Anti-MUC1 antibody
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Results of the study indicate that combined action of anti-MUC1 and RA is more effective than monotherapy in relation to examined cancer related factors. Such treatment can be considered as new, promising strategy in gastric cancer therapy.

Pair Name	Rosmarinic acid, Paclitaxel
Phytochemical	Rosmarinic acid
Drug	Paclitaxel
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Rosmarinic acid exerted chemo-preventive and therapeutic potential alone or in combination with Paclitaxel. Moreover, rosmarinic acid targets numerous signaling pathways associated with breast cancer.

Pair Name	Rutin, Fluorouracil
Phytochemical	Rutin
Drug	Fluorouracil
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Synergistic effects of 5-FU/rutin combination on PC3 cells line enhanced apoptosis, p53 gene expression, and down-regulation of Bcl-2 protein, compared to control separate application. 5-FU/rutin combination does seem an interesting therapeutic pathway to be further investigated.

Pair Name	Salvianolic acid B, Celecoxib
Phytochemical	Salvianolic acid B
Drug	Celecoxib
Disease Info	[ICD-11: 2C31.Z]	Head and neck squamous cell carcinoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	These results strongly suggest that combination of Sal-B, a multifunctional anticancer agent, with low-dose celecoxib holds potential as a new preventive strategy in targeting inflammatory-associated tumor development.

Pair Name	Shogaol, Methotrexate
Phytochemical	Shogaol
Drug	Methotrexate
Disease Info	[ICD-11: 2B33.3]	Acute lymphoblastic leukemia		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The current study revealed the in vivo novel anti-leukaemic role of ginger extract, promoted by MTX. Moreover, 6-shogaol was introduced as the major player of ginger cytotoxicity through inducing p53 activity and ROS generation.

Pair Name	Silibinin, Paclitaxel
Phytochemical	Silibinin
Drug	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our results showed that combination of chemotherapy drugs of silibinin and paclitaxel can be more efficient in treatment of ovarian cancer cells.

Pair Name	Sulforaphane, Cisplatin
Phytochemical	Sulforaphane
Drug	Cisplatin
Disease Info	[ICD-11: 2C28]	Malignant mesothelioma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells

Pair Name	Sulforaphane, MiR-15b-5p
Phytochemical	Sulforaphane
Drug	MiR-15b-5p
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our data demonstrate that this combined treatment leads to a very high proportion of apoptotic HT-29 cells (over 85%), a value higher than the sum of the values of apoptotic cells obtained after singularly administered regents (either SFN or R8-PNA-a15b).

Pair Name	Tangeretin, Fluorouracil
Phytochemical	Tangeretin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	To our knowledge gained from literature, this study is the first to describe synergistic activity of TAN and 5-FU against colorectal cancer cells.

Pair Name	Tenacissoside G, Fluorouracil
Phytochemical	Tenacissoside G
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	TG potentiated 5-FU's inhibitory activity to human colorectal cancer through arresting cell cycle progression and inducing p53-mediated apoptosis, which may present a novel strategy in CRC therapies and contribute to the optimizing clinical application of 5-FU.

Pair Name	Thymoquinone, Fluorouracil
Phytochemical	Thymoquinone
Drug	Fluorouracil
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	TQ and 5-FU probably showed synergistic effect on both of cell cycle and apoptosis of tested TNBC cell lines. Our study reveals that TQ can synergise 5-FU action, and increase its anticancer efficiency against TNBC cells, which might be good choice in drug development for TNBC treatment.

Pair Name	Thymoquinone, Propranolol
Phytochemical	Thymoquinone
Drug	Propranolol
Disease Info	[ICD-11: 2C23.Z]	Laryngeal cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	The effect of thymoquinone and propranolol combination on epidermoid laryngeal carcinoma cell.

Pair Name	Thymoquinone, Topotecan
Phytochemical	Thymoquinone
Drug	Topotecan
Disease Info	[ICD-11: 2A60.Z]	Acute myeloid leukemia		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Thymoquinone, when combined with topotecan in noncytotoxic doses, produced synergistic antiproliferative and proapoptotic effects in AML cells

Pair Name	Vanillin, Fluorouracil
Phytochemical	Vanillin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Vanillin is deemed to be a promising anticancer candidate by inhibiting NNMT and may attenuate NNMT‑induced resistance to 5‑Fu in human CRC therapy with few side effects.

Pair Name	Vitamin C, Topotecan
Phytochemical	Vitamin C
Drug	Topotecan
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Synergistic enhancement of topotecan-induced cell death by ascorbic acid in human breast MCF-7 tumor cells.

Pair Name	Zerumbone, Gefitinib
Phytochemical	Zerumbone
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Our study suggested that zerumbone combined with gefitinib could effectively inhibit lung cancer for multi-model therapies, including the inhibition of tumor growth, angiogenesis, induce cell apoptosis, and ferroptosis.

Pair Name	Zeylenone, Cisplatin
Phytochemical	Zeylenone
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Zeylenone synergizes with cisplatin in osteosarcoma by enhancing DNA damage, apoptosis, and necrosis via the Hsp90/AKT/GSK3β and Fanconi anaemia pathway

Pair Name	Cepharanthine, Cisplatin
Phytochemical	Cepharanthine
Drug	Cisplatin
Disease Info	[ICD-11: 2B70]	Esophageal cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals

Pair Name	Chrysin, Fluorouracil
Phytochemical	Chrysin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Potentiating activities of chrysin in the therapeutic efficacy of 5-fluorouracil in gastric cancer cells

Pair Name	Cordycepin, Cisplatin
Phytochemical	Cordycepin
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Phosphorylation
Result	Our results suggested that Cor in combination with DDP could be an additional therapeutic option for the treatment of DDP-resistant NSCLC.

Pair Name	Liquiritin, Cisplatin
Phytochemical	Liquiritin
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo

Pair Name	Rosmarinic acid, Cisplatin
Phytochemical	Rosmarinic acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Cellular tumor antigen p53		Expression
Result	Rosmarinic acid reverses non-small cell lung cancer cisplatin resistance by activating the MAPK signaling pathway