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3-Rhamnosyl-Glucosyl Quercetin, Quercetin 3 Rutinoside, Quercetin, 3-Rhamnosyl-Glucosyl, Quercetin-3-Rutinoside, Rutin, Rutoside

No.	Title	Href
1	P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin. Biomed Res Int. 2019 Nov 6;2019:6407210. doi: 10.1155/2019/6407210.	`Click`
2	Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions. Naunyn Schmiedebergs Arch Pharmacol. 2019 Feb;392(2):165-175. doi: 10.1007/s00210-018-1579-0.	`Click`
3	Synergetic Impact of Combined 5-Fluorouracil and Rutin on Apoptosis in PC3 Cancer Cells through the Modulation of P53 Gene Expression. Adv Pharm Bull. 2019 Aug;9(3):462-469. doi: 10.15171/apb.2019.055.	`Click`

No.

Title

Href

P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin. Biomed Res Int. 2019 Nov 6;2019:6407210. doi: 10.1155/2019/6407210.

Click

Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions. Naunyn Schmiedebergs Arch Pharmacol. 2019 Feb;392(2):165-175. doi: 10.1007/s00210-018-1579-0.

Click

Synergetic Impact of Combined 5-Fluorouracil and Rutin on Apoptosis in PC3 Cancer Cells through the Modulation of P53 Gene Expression. Adv Pharm Bull. 2019 Aug;9(3):462-469. doi: 10.15171/apb.2019.055.

Click

Name	Rutin
PubChem CID	5280805
Molecular Weight	610.5g/mol
Synonyms	3-Rhamnosyl-Glucosyl Quercetin, Quercetin 3 Rutinoside, Quercetin, 3-Rhamnosyl-Glucosyl, Quercetin-3-Rutinoside, Rutin, Rutoside
Formula	C₂₇H₃₀O₁₆
SMILES	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O
InChI	1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-/m0/s1
InChIKey	IKGXIBQEEMLURG-NVPNHPEKSA-N
CAS Number	153-18-4
ChEMBL ID	CHEMBL226335
ChEBI ID	CHEBI:28527
Herb ID	HBIN042670
Drug Bank ID	DB01698
KEGG ID	C05625
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	QiaoMai
Use Part	Seed
Habitat	China
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Caryophyllales 　　　　-->Family: Polygonaceae 　　　　　-->Genus: Fagopyrum 　　　　　　-->Species: Fagopyrum esculentum

Pair Name	Rutin, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2C82.0]	Prostate cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
Gene Regulation	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
Result	Synergistic effects of 5-FU/rutin combination on PC3 cells line enhanced apoptosis, p53 gene expression, and down-regulation of Bcl-2 protein, compared to control separate application. 5-FU/rutin combination does seem an interesting therapeutic pathway to be further investigated.

Pair Name	Rutin, Oxaliplatin
Partner Name	Oxaliplatin
Disease Info	[ICD-11: 2B72.Z]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Phosphorylation	MAPK14	hsa1432
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP7	hsa840
	Up-regulation	Cleavage	CASP8	hsa841
	Up-regulation	Cleavage	CASP9	hsa842
In Vitro Model	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
Result	P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin

Pair Name	Rutin, Orlistat
Partner Name	Orlistat
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	FAS	hsa355
Gene Regulation	Up-regulation	Expression	GSS	hsa2937
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vitro Model	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0480
Result	Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions