narciclasine
| Name | Narciclasine | ||
| PubChem CID | 72376 | ||
| Molecular Weight | 307.25g/mol | ||
| Synonyms |
narciclasine |
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| Formula | C₁₄H₁₃NO₇ | ||
| SMILES | C1OC2=C(O1)C(=C3C(=C2)C4=CC(C(C(C4NC3=O)O)O)O)O | ||
| InChI | 1S/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)/t6-,9+,10+,12-/m0/s1 | ||
| InChIKey | LZAZURSABQIKGB-AEKGRLRDSA-N | ||
| CAS Number | 29477-83-6 | ||
| ChEMBL ID | CHEMBL98745 | ||
| ChEBI ID | CHEBI:70169 | ||
| Herb ID | HBIN036344 | ||
| KEGG ID | C08533 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | ShuiXian | ||
| Use Part | Bulb | ||
| Habitat | JiangSu, ZheJiang, FuJian, GuangDong, SiChuan, GuiZhou | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asparagales
-->Family: Amaryllidaceae
-->Genus: Narcissus
-->Species: Narcissus tazetta
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| Pair Name | Narciclasine, Tamoxifen | |||
| Partner Name | Tamoxifen | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Target-->STAT3 | |||
| Gene Regulation | Down-regulation | Phosphorylation | STAT3 | hsa6774 |
| Down-regulation | Expression | MYC | hsa4609 | |
| Down-regulation | Expression | CCND1 | hsa595 | |
| Down-regulation | Expression | BIRC5 | hsa332 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| Result | Our findings successfully highlight the STAT3 as the direct therapeutic target of Nar in ER-positive breast cancer cells, especially, Nar leaded STAT3 degradation as a promising strategy for the tamoxifen-resistant breast cancer treatment. | |||
