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7-methoxy-8-(3-methylpent-2-enyl)coumarin, osthol, osthole

No.	Title	Href
1	Effect of combined treatment with lobaplatin and osthole on inducing apoptosis and inhibiting proliferation in human breast cancer MDA-MB-231 cells. Med Oncol. 2021 Nov 27;39(1):16. doi: 10.1007/s12032-021-01609-4.	`Click`
2	Coumarins modulate the anti-glioma properties of temozolomide. Eur J Pharmacol. 2020 Aug 15;881:173207. doi: 10.1016/j.ejphar.2020.173207.	`Click`

No.

Title

Href

Effect of combined treatment with lobaplatin and osthole on inducing apoptosis and inhibiting proliferation in human breast cancer MDA-MB-231 cells. Med Oncol. 2021 Nov 27;39(1):16. doi: 10.1007/s12032-021-01609-4.

Click

Coumarins modulate the anti-glioma properties of temozolomide. Eur J Pharmacol. 2020 Aug 15;881:173207. doi: 10.1016/j.ejphar.2020.173207.

Click

Name	Osthol
PubChem CID	10228
Molecular Weight	244.28g/mol
Synonyms	7-methoxy-8-(3-methylpent-2-enyl)coumarin, osthol, osthole
Formula	C₁₅H₁₆O₃
SMILES	CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
InChI	1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
InChIKey	MBRLOUHOWLUMFF-UHFFFAOYSA-N
CAS Number	484-12-8
ChEMBL ID	CHEMBL52229
ChEBI ID	CHEBI:69832
Herb ID	HBIN038387
KEGG ID	C09280
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	CangZhu
Use Part	Rhizome
Habitat	HeNan, ShanDong
Flavor	Pungent, Bitter
Meridian Tropism	Spleen, Stomach, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asterales 　　　　-->Family: Asteraceae 　　　　　-->Genus: Atractylodes 　　　　　　-->Species: Atractylodes lancea

Chineses Pinyin	DuHuo
Use Part	Root
Habitat	HuBei, SiChuan, JiangXi
Flavor	Pungent; Bitter
Meridian Tropism	Kidney; Bladder
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Apiales 　　　　-->Family: Apiaceae 　　　　　-->Genus: Angelica 　　　　　　-->Species: Angelica pubescens

Pair Name	Osthol, Lobaplatin
Partner Name	Lobaplatin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	TP53	hsa7157
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	CASP3	hsa836
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	OST enhanced the apoptosis-mediated growth inhibitory effect of lobaplatin on breast cancer cells and has potential for the treatment of breast cancer in the future.

Pair Name	Osthol, Temozolomide
Partner Name	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	BECN1	hsa8678
In Vitro Model	T98G	Glioblastoma	Homo sapiens (Human)	CVCL_0556
In Vitro Model	MOG-G-CCM	Anaplastic astrocytoma	Homo sapiens (Human)	CVCL_2613
Result	Our results indicated that osthole effectively eliminated glioma cells via apoptosis, what was correlated with Bcl-2/Beclin 1 complex formation. Considering the anti-migratory effect, osthole and Temozolomide display antiglioma potential but it needs further extensive studies.