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magnoflorine, magnoflorine iodide, (S)-isomer, magnoflorine perchlorate, (S)-isomer

No.	Title	Href
1	Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways. Biomed Pharmacother. 2020 Jan;121:109139. doi: 10.1016/j.biopha.2019.109139.	`Click`
2	Heterogeneous Cellular Response of Primary and Metastatic Human Gastric Adenocarcinoma Cell Lines to Magnoflorine and Its Additive Interaction with Docetaxel. Int J Mol Sci. 2023 Oct 24;24(21):15511. doi: 10.3390/ijms242115511.	`Click`

No.

Title

Href

Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways. Biomed Pharmacother. 2020 Jan;121:109139. doi: 10.1016/j.biopha.2019.109139.

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Heterogeneous Cellular Response of Primary and Metastatic Human Gastric Adenocarcinoma Cell Lines to Magnoflorine and Its Additive Interaction with Docetaxel. Int J Mol Sci. 2023 Oct 24;24(21):15511. doi: 10.3390/ijms242115511.

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Name	Magnoflorine
PubChem CID	73337
Molecular Weight	342.4g/mol
Synonyms	magnoflorine, magnoflorine iodide, (S)-isomer, magnoflorine perchlorate, (S)-isomer
Formula	C₂₀H₂₄NO₄+
SMILES	C[N+]1(CCC2=CC(=C(C3=C2C1CC4=C3C(=C(C=C4)OC)O)O)OC)C
InChI	1S/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1/t13-/m0/s1
InChIKey	YLRXAIKMLINXQY-ZDUSSCGKSA-O
CAS Number	2141-09-5
ChEMBL ID	CHEMBL235428
ChEBI ID	CHEBI:6641
Herb ID	HBIN034216
KEGG ID	C09581
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	HuangLian
Use Part	Rhizome
Habitat	SiChuan, YunNan, HuBei
Flavor	Bitter
Meridian Tropism	Heart; Spleen; Stomach; Liver; Gallbladder; Large Intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Ranunculaceae 　　　　　-->Genus: Coptis 　　　　　　-->Species: Coptis chinensis

Pair Name	Magnoflorine, Docetaxel
Partner Name	Docetaxel
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
In Vitro Model	23132/87	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_1046
	AGS	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0139
	MKN74	Gastric tubular adenocarcinoma	Homo sapiens (Human)	CVCL_2791
	NCI-N87	Gastric tubular adenocarcinoma	Homo sapiens (Human)	CVCL_1603
In Vivo Model	Zebrafish embryos of the AB strain were studied under standard conditions (28.5 °C, 14 h light/10 h dark cycle) in an incubator.
Result	Heterogeneous Cellular Response of Primary and Metastatic Human Gastric Adenocarcinoma Cell Lines to Magnoflorine and Its Additive Interaction with Docetaxel

Pair Name	Magnoflorine, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BECN1	hsa8678
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Phosphorylation	MAPK14	hsa1432
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Down-regulation	Phosphorylation	PIK3CA	hsa5290
	Down-regulation	Expression	SQSTM1	hsa8878
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
In Vivo Model	1×10⁷ MCF-7 cells suspended in 0.2 ml PBS were injected into the right flank of each mouse at a single site.
Result	Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways