damnacanthal
| Name | Damnacanthal | ||
| PubChem CID | 2948 | ||
| Molecular Weight | 282.25g/mol | ||
| Synonyms |
damnacanthal |
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| Formula | C₁₆H₁₀O₅ | ||
| SMILES | COC1=C2C(=CC(=C1C=O)O)C(=O)C3=CC=CC=C3C2=O | ||
| InChI | 1S/C16H10O5/c1-21-16-11(7-17)12(18)6-10-13(16)15(20)9-5-3-2-4-8(9)14(10)19/h2-7,18H,1H3 | ||
| InChIKey | IPDMWUNUULAXLU-UHFFFAOYSA-N | ||
| CAS Number | 477-84-9 | ||
| ChEMBL ID | CHEMBL212948 | ||
| ChEBI ID | CHEBI:93633 | ||
| Herb ID | HBIN022626 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | MangGuoYe | ||
| Use Part | Leaf | ||
| Habitat | FuJian, TaiWan, GuangDong, HaiNan, GuangXi, YunNan | ||
| Flavor | Mildly sour | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Anacardiaceae
-->Genus: Mangifera
-->Species: Mangifera indica
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| Chineses Pinyin | HuCi | ||
| Use Part | Whole Herb | ||
| Habitat | ZheJiang, JiangXi, GuangDong, HuNan | ||
| Flavor | Sweet, Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Gentianales
-->Family: Rubiaceae
-->Genus: Damnacanthus
-->Species: Damnacanthus indicus
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| Chineses Pinyin | TuLianQiao | ||
| Use Part | Bark | ||
| Habitat | YunNan, GuangXi | ||
| Flavor | Bitter | ||
| Meridian Tropism | Lung, Triple burner | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Gentianales
-->Family: Rubiaceae
-->Genus: Hymenodictyon
-->Species: Hymenodictyon excelsum
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| Chineses Pinyin | BaJiTian | ||
| Use Part | Root | ||
| Habitat | GuangDong, GuangXi, FuJian | ||
| Flavor | Pungent; Sweet | ||
| Meridian Tropism | Kidney; Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Magnoliopsida
-->Order: Gentianales
-->Family: Rubiaceae
-->Genus: Morinda
-->Species: Morinda officinalis
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| Pair Name | Damnacanthal, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | CASP7 | hsa840 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Down-regulation | Expression | ESR1 | hsa2099 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Down-regulation | Expression | XIAP | hsa331 | |
| In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
| Result | Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin against Human Breast Cancer MCF-7 Cells in Vitro | |||
