InterPAD - DETAILS

BRD4770, 1374601-40-7, Methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate, BRD-4770, GTPL7016, methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate, BRD 4770, AOB3886, CHEMBL3970748, SCHEMBL16569005, EX-A692, CHEBI:131143, BDBM225263, BCP10433, BRD4770?, ZEC60140, MFCD23143627, NSC777671, s7591, AKOS026750266, CCG-268804, CS-3446, NSC-777671, SB19344, 2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester, NCGC00351780-01, NCGC00351780-04, AC-35910, AS-16771, DA-35008, HY-16705, BRD4770, >=98% (HPLC), FT-0733814, J-690148, BRD-K72264770-001-01-6, Q27075478, methyl 2-benzamido-1-(3-phenylpropyl)-1,3-benzodiazole-5-carboxylate, methyl 2-benzamido-1-(3-phenylpropyl)-1H-1,3-benzodiazole-5-carboxylate

No.	Title	Href
1	Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis. 2013 Jun 27;4(6):e690. doi: 10.1038/cddis.2013.191.	`Click`

No.

Title

Href

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis. 2013 Jun 27;4(6):e690. doi: 10.1038/cddis.2013.191.

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Name	BRD4770
PubChem CID	72193870
Molecular Weight	413.5g/mol
Synonyms	BRD4770, 1374601-40-7, Methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate, BRD-4770, GTPL7016, methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate, BRD 4770, AOB3886, CHEMBL3970748, SCHEMBL16569005, EX-A692, CHEBI:131143, BDBM225263, BCP10433, BRD4770?, ZEC60140, MFCD23143627, NSC777671, s7591, AKOS026750266, CCG-268804, CS-3446, NSC-777671, SB19344, 2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester, NCGC00351780-01, NCGC00351780-04, AC-35910, AS-16771, DA-35008, HY-16705, BRD4770, >=98% (HPLC), FT-0733814, J-690148, BRD-K72264770-001-01-6, Q27075478, methyl 2-benzamido-1-(3-phenylpropyl)-1,3-benzodiazole-5-carboxylate, methyl 2-benzamido-1-(3-phenylpropyl)-1H-1,3-benzodiazole-5-carboxylate
Drug Type	Small molecule
Formula	C₂₅H₂₃N₃O₃
SMILES	COC(=O)C1=CC2=C(C=C1)N(C(=N2)NC(=O)C3=CC=CC=C3)CCCC4=CC=CC=C4
InChI	1S/C25H23N3O3/c1-31-24(30)20-14-15-22-21(17-20)26-25(27-23(29)19-12-6-3-7-13-19)28(22)16-8-11-18-9-4-2-5-10-18/h2-7,9-10,12-15,17H,8,11,16H2,1H3,(H,26,27,29)
InChIKey	UCGWYCMPZXDHNR-UHFFFAOYSA-N
CAS Number	1374601-40-7
ChEMBL ID	CHEMBL3970748
ChEBI ID	CHEBI:131143
TTD ID	D0LA0P
Toxicity	Organism	Test Type	Route(Dose)
Structure			Download 2D MOL 3D MOL

Pair Name	Gossypol, BRD4770
Partner Name	Gossypol
Disease Info	[ICD-11: 2C10.Z]	Pancreatic cancer		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Up-regulation	Phosphorylation	TP53	hsa7157
	Up-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Expression	BNIP3	hsa664
In Vitro Model	PANC-1	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0480
Result	The combination of gossypol and BRD4770 increased LC3-II levels and the autophagosome number in PANC-1 cells, and the compound combination appears to act in a BNIP3 (B-cell lymphoma 2 19-kDa interacting protein)-dependent manner, suggesting that these compounds act together to induce autophagy-related cell death in pancreatic cancer cells.