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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name Dexamethasone
PubChem CID 5743
Molecular Weight 392.5g/mol
Synonyms

dexamethasone, 50-02-2, Decadron, Maxidex, Dexamethazone, Hexadecadrol, Dexasone, Hexadrol, Aeroseb-Dex, Fluormethylprednisolone, Desametasone, Superprednol, Visumetazone, Cortisumman, Decaderm, Decaspray, Dexacortal, Dexacortin, Gammacorten, Millicorten, Oradexon, Auxiron, Calonat, Dexason, Dexone, Dectancyl, Deltafluorene, Desamethasone, Desameton, Fortecortin, Mediamethasone, Mymethasone, Decalix, Dekacort, Dexacort, Dexameth, Dinormon, Loverine, Luxazone, Azium, Dexa-Scheroson, Prednisolone F, Dexa-sine, Isopto-Dex, Aeroseb-D, Anaflogistico, Aphtasolon, Decacortin, Decasone, Dergramin, Desadrene, Deseronil, Dexadeltone, Dexafarma, Dexalona, Dexapolcort, Dexinolon, Dexinoral, Dextelan, Policort, Spoloven, Corsone, Deronil, Dexapos, Mexidex, Sunia Sol D, Bisu DS, Dexa Mamallet, Dexa-Cortidelt, Dexa-Cortisyl, Prednisolon F, Lokalison F, Ocu-trol, Dex-ide, SK-Dexamethasone, Dexamethasonum, Dexaprol, Fluormone, Decagel, Dexone 4, Hexadrol Elixir, Pet Derm III, Dexamethasone Intensol, Hl-dex, Methylfluorprednisolone, Dexone 0.5, Dexone 1.5, Dexametasona, Fluorocort, Decaject, Decameth, Dexone 0.75, Dexpak, Dxms, Dexamethasone alcohol, Hexadrol Tablets, Desametasone [DCIT], Decacort, Dexamonozon, Dextenza, Turbinaire, Ozurdex, 9alpha-Fluoro-16alpha-methylprednisolone, Dexametasona [INN-Spanish], Dexamethasonum [INN-Latin], Dezone, Decadron Tablets, Elixir, Azium (Veterinary), Dexametasone, Dexamethansone, Adexone, Osurdex, Posurdex, Dexycu, DexaSite, OTO-104, Corson, 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol, 16alpha-Methyl-9alpha-fluoroprednisolone, (3H)-Dexamethasone, Azimycin (Veterinary), delta1-9alpha-Fluoro-16alpha-methylcortisol, MK 125, NSC 34521, 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone, Naquasone (Veterinary), Tresaderm (Veterinary), CCRIS 7067, Diodex, DTXSID3020384, HSDB 3053, ISV-305, (11beta,16alpha)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, Zema-Pak, 16-alpha-Methyl-9-alpha-fluoroprednisolone, 9-alpha-Fluoro-16-alpha-methylprednisolone, UNII-7S5I7G3JQL, 16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone, EINECS 200-003-9, 7S5I7G3JQL, MFCD00064136, NSC-34521, 16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone, DXM [Steroid], 16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone, HEMADY, 16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol, Dexamethasone (GMP), Dexamethasone, topical, CHEBI:41879, AI3-50934, delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol, 9A-FLUORO-16BETA-METHYLPREDNISOLONE, Prednisolone, 9alpha-fluoro-16alpha-methyl-, DTXCID10384, MLS001332507, 16.alpha.-Methyl-9.alpha.-fluoroprednisolone, Dexamethasone [USP:INN:BAN:JAN], DXM (Steroid), 9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione, [3H]-dexamethasone, DEXA, [3H]dexamethasone, CIPRODEX COMPONENT DEXAMETHASONE, Decaject-L.A., MAXITROL COMPONENT DEXAMETHASONE, TOBRADEX COMPONENT DEXAMETHASONE, (1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one, DEXACIDIN COMPONENT DEXAMETHASONE, DEXASPORIN COMPONENT DEXAMETHASONE, Aphthasolone, TOBRADEX ST COMPONENT DEXAMETHASONE, Dexa-Mamallet, 9.alpha.-Fluoro-16.alpha.-methylprednisolone, Dexametasona (INN-Spanish), Dexamethasonum (INN-Latin), (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one, C22H29FO5, DEXAMETHASONE (MART.), DEXAMETHASONE [MART.], 16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol, DEXAMETHASONE (USP-RS), DEXAMETHASONE [USP-RS], 1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone, Dexamethasone (USP:INN:BAN:JAN), DEXAMETHASONE (EP MONOGRAPH), DEXAMETHASONE [EP MONOGRAPH], DEXAMETHASONE (USP MONOGRAPH), DEXAMETHASONE [USP MONOGRAPH], Dexamethasone Base, Decadron (TN), (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, SMR000857119, BETAMETHASONE IMPURITY A (EP IMPURITY), BETAMETHASONE IMPURITY A [EP IMPURITY], dexamethasone (tetramethyl-rhodamine conjugated ), Prednisolone, 9.alpha.-fluoro-16.alpha.-methyl-, alin, Amplidermis, Cortidexason, Dexafluorene, Dexamecortin, Dexamethsone, Fluorodelta, Aacidexam, Baycadron, Decadrol, Dexabliss, Dexachel, Dexalocal, Dexasine, Spersadex, .delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol, 16.alpha.-Methyl-9.alpha.-fluoro-.delta.(sup1)-hydrocortisone, Dxevo, NSC34521, TaperDex, Aknichthol Dexa, Alin Oftalmico, Anemul mono, Azium Solution, Dexium Tablets, Azium Powder, Dexa-Rhinosan, .gamma.corten, ZoDex, 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, Alin Depot, Baycuten N, Lokalison-F, Apo-dexamethasone, Decadron DP, Dexasone 4mg, Alba-Dex, Zonometh Solution, Dexameth-A-Vet, PHL-dexamethasone, PMS-dexamethasone, TaperDex 6-day, TaperDex 7-day, Decasone R.p., Dexamethasone-omega, NCGC00091019-08, Dexasone 0.5mg, TaperDex 12-day, HiDex 6-day, Dexasone 0.75mg, Sandoz Dexamethasone, Dexamethasone1.5 mg, Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-, Dexamethasone Solution, Dexamethasone Injection, DEXYCU KIT, Maxidex Ont 0.1%, Maxidex Sus 0.1%, Azium Boluses 10 mg, Dexamethasone 1.5 mg, Pet Derm III Tablets, Dexameth-A-Vet Injection, Spectrum5_002019, Azium Tablets 0.25 mg, DEXAMETHASONE 6-Day, Azium Oral Solution 2 mg, DEXAMETHASONE [MI], MolMap_000018, (9R,14S)-Dexamethasone, DEXAMETHASONE [INN], DEXAMETHASONE [JAN], SCHEMBL3774, 16-alpha-Methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione, 16-alpha-Methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4-diene-3,20-dione, 4-alpha-Fluoro-16-alpha-methyl-11-beta,17,21-trihydroxypregna-1,4-diene-3,20-dione, 9-alpha-Fluoro-16-alpha-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione, DEXAMETHASONE [HSDB], BIDD:PXR0060, BSPBio_000995, DEXAMETHASONE [VANDF], MLS001055412, MLS001332508, BIDD:ER0494, Dexamethasone Sterile Solution, sustained-release dexamethasone, DEXAMETHASONE [WHO-DD], DEXAMETHASONE [WHO-IP], CHEMBL384467, GTPL2768, GTPL3447, SGCUT00126, 9-Fluoro-16-methylprednisolone, Ak Dex Oph Otic Soln 0.1%, DEXAMETHASONE [EMA EPAR], BDBM18207, Dexamethasone (anti-inflammatory), Dexamethasone (JP17/USP/INN), 1p93, DEXAMETHASONE [GREEN BOOK], HMS1792A17, HMS1990A17, HMS2089N13, HMS2235F08, HMS3039L11, HMS3259N11, HMS3403A17, Azium Aqueous Suspension Veterinary, DEXAMETHASONE [ORANGE BOOK], AMY28815, to_000038, Tox21_200122, Dexamethasone, >=97.0% (HPLC), HB2521, HY-14648G, IBI-10090, MK-125, s1322, Dexamethasone 1.0 mg/ml in Methanol, DEXAMETHASONUM [WHO-IP LATIN], PMS Dexamethasone Elixir 0.5mg/5ml, AKOS005259009, AKOS015895509, 1ST2218, CCG-264887, CS-1505, DB01234, KS-1451, NC00645, alpha -Fluoro-16-alpha -methylcortisol, CAS-50-02-2, Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-, SMP1_000092, Dexamethasone, >=98% (HPLC), powder, NCGC00091019-01, NCGC00091019-02, NCGC00091019-03, NCGC00091019-04, NCGC00091019-05, NCGC00091019-06, NCGC00091019-07, NCGC00091019-23, NCGC00257676-01, (11beta,16alpha)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione labeled with tritium, (8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]ph, 23495-06-9, 9alpha-fluoro-16alpha-methyl-Prednisolone, AC-11056, DEXAMETHASONE COMPONENT OF CIPRODEX, DEXAMETHASONE COMPONENT OF MAXITROL, DEXAMETHASONE COMPONENT OF TOBRADEX, HY-14648, NCI60_003067, Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, labeled with tritium, (11beta,16alpha)-, SMR001227192, DEXAMETHASONE COMPONENT OF DEXACIDIN, Fluoro-9alpha Methyl-16alpha Prednisolone, 16alpha -Methyl-9alpha -fluoroprednisolone, 9alpha -Fluoro-16alpha -methylprednisolone, DEXAMETHASONE COMPONENT OF DEXASPORIN, Dexamethasone, tested according to Ph.Eur., CS-0626118, DEXAMETHASONE COMPONENT OF TOBRADEX ST, NS00000344, EN300-52607, D00292, Dexamethasone, meets USP testing specifications, Prednisolone, 9alpha -fluoro-16alpha -methyl-, 9.alpha.-Fluoro-16.alpha.-methyl-1,20-dione, AB00918428-05, AB00918428-08, AB00918428-09, AB00918428_10, 16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol, 16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone, Dexamethasone, VETRANAL(TM), analytical standard, Q422252, 1-Dehydro-16alpha-methyl-0alpha-fluorohydrocortisone, delta(Sup1)-9-alpha-fluoro-16-alpha-methylcortisol, Q-200939, BRD-K38775274-001-02-3, BRD-K38775274-001-06-4, DEXAMETHASONE ACETATE IMPURITY A [EP IMPURITY], 1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone, 9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione, Dexamethasone, British Pharmacopoeia (BP) Assay Standard, Z756391748, Pregna-1,4-diene-3,20-dione, 9-fluoro-11alpha -methyl-, Dexamethasone, European Pharmacopoeia (EP) Reference Standard, WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1, Dexamethasone, powder, BioReagent, suitable for cell culture, >=97%, Dexamethasone, United States Pharmacopeia (USP) Reference Standard, 16-.alpha.-Methyl-9-.alpha.-fluoro-1,17-.alpha.,21-triol-3,20-dione, 4.alpha.-Fluoro-16.alpha.-methyl-11.beta.-17,4-diene-3,20-dione, Pregna-1,20-dione, 9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methyl-, 16.alpha.-Methyl-9.alpha.-fluoro-11.beta.-17.alpha.-21-trihydroxypregna-1,20-dione, 9-Fluoro-11.beta.,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione, 9-fluoro-16alpha-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione, 9.alpha.-Fluoro-11.beta.-17.alpha.- 21-trihydroxy-16.alpha.-methylpregna-1,20-dione, 9alpha-Fluoro-16alpha-methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione, Dexamethasone for peak identification, European Pharmacopoeia (EP) Reference Standard, Dexamethasone for system suitability, European Pharmacopoeia (EP) Reference Standard, Dexamethasone, Pharmaceutical Secondary Standard; Certified Reference Material, Dexamethasone, powder, gamma-irradiated, BioXtra, suitable for cell culture, >=80% (HPLC), Pregna-1,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11.beta.,16.alpha.)-, (11.BETA.,16.ALPHA.)-9-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE, (11alpha,14beta,16alpha,17alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, (1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one, (1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadeca-3,6-dien-5-one, 1050677-47-8, 9.alpha.-Fluoro-16.alpha.-methyl-11.beta.,21.beta.-trihydroxy-pregna-1,4-diene-3,20-dione, PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11,17,21-TRIHYDROXY-16-METHYL-,(11.BETA.,16.ALPHA.)-9-FLUORO-11.BETA.,17,21-TRIHYDROXY-16.ALPHA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE

Drug Type Small molecule
Formula C₂₂H₂₉FO₅
SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
InChI 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChIKey UREBDLICKHMUKA-CXSFZGCWSA-N
CAS Number 50-02-2
ChEMBL ID CHEMBL384467
ChEBI ID CHEBI:41879
TTD ID D0IT2G
Drug Bank ID DB01234
KEGG ID D00292
Toxicity Organism Test Type Route(Dose)
rat LD50 intraperitoneal(165 mg/kg)
mouse LD50 intraperitoneal(254 mg/kg)
rat LD50 oral(322 mg/kg)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 922
Pair Name GingerenoneA, Dexamethasone
Partner Name GingerenoneA
Disease Info [ICD-11: 2B33.3] Acute lymphoblastic leukemia Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression CDKN1A hsa1026
Down-regulation Expression FASN hsa2194
Up-regulation Expression MDM2 hsa4193
Up-regulation Expression TP53 hsa7157
In Vitro Model CCRF-CEM Childhood T acute lymphoblastic leukemia Homo sapiens (Human) CVCL_0207
NALM-6 Adult B acute lymphoblastic leukemia Homo sapiens (Human) CVCL_0092
RN95 B‐ALL subline derived from a 12‐year‐old Iranian girl with relapsed ALL Homo sapiens (Human) N.A.
Result Our findings may provide novel strategies for therapeutic intervention to ameliorate pALL outcomes.
03. Reference
No. Title Href
1 GingerenoneA overcomes dexamethasone resistance by activating apoptosis and inhibiting cell proliferation in pediatric T-ALL cells. Cancer Sci. 2023 Oct;114(10):3984-3995. doi: 10.1111/cas.15936 Click
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