bixin
| Name | Bixin | ||
| PubChem CID | 5281226 | ||
| Molecular Weight | 394.5g/mol | ||
| Synonyms |
bixin |
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| Formula | C₂₅H₃₀O₄ | ||
| SMILES | CC(=CC=CC=C(C)C=CC=C(C)C=CC(=O)OC)C=CC=C(C)C=CC(=O)O | ||
| InChI | 1S/C25H30O4/c1-20(12-8-14-22(3)16-18-24(26)27)10-6-7-11-21(2)13-9-15-23(4)17-19-25(28)29-5/h6-19H,1-5H3,(H,26,27)/b7-6+,12-8+,13-9+,18-16+,19-17+,20-10+,21-11+,22-14+,23-15- | ||
| InChIKey | RAFGELQLHMBRHD-SLEZCNMESA-N | ||
| CAS Number | 6983-79-5 | ||
| ChEMBL ID | CHEMBL1172615 | ||
| ChEBI ID | CHEBI:3136 | ||
| Herb ID | HBIN018639 | ||
| KEGG ID | C08582 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | HongMu | ||
| Use Part | Root cortex, leaf, sarcocarp and seed | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malvales
-->Family: Bixaceae
-->Genus: Bixa
-->Species: Bixa orellana
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| Pair Name | Bixin, Dacarbazine | |||
| Partner Name | Dacarbazine | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Up-regulation | Activity | CASP3 | hsa836 |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | A2058 | Amelanotic melanoma | Homo sapiens (Human) | CVCL_1059 |
| Result | These data suggest that bixin exerts intrinsic antimelanoma activity by mechanisms complementary to those of dacarbazine, encouraging its use in combined therapy for cutaneous melanoma treatment. | |||
| Pair Name | Bixin, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | ABCC1 | hsa4363 |
| Down-regulation | Expression | ABCC2 | hsa1244 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
| Result | The administration of bixin or fucoxanthin decreases the expression of ABCC1 and ABCC2. Both carotenoids, either alone or in combination with cisplatin, upregulated p53 gene expression indicating the mechanism of proliferation inhibition and apoptosis occurs via the p53 caspase-independent pathway. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Bixin, an apocarotenoid isolated from Bixa orellana L., sensitizes human melanoma cells to dacarbazine-induced apoptosis through ROS-mediated cytotoxicity. Food Chem Toxicol. 2019 Mar;125:549-561. doi: 10.1016/j.fct.2019.02.013. | Click |
| 2 | Bixin and Fuxoxanthin Alone and in Combination with Cisplatin Regulate ABCC1 and ABCC2 Transcription in A549 Lung Cancer Cells. J Pharm Bioallied Sci. 2023 Jan-Mar;15(1):15-20. doi: 10.4103/jpbs.jpbs_50_23. | Click |
