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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name NaI*131
Drug Type Not Available
Toxicity Organism Test Type Route(Dose)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 150
Ref_1
Pair Name Gambogic acid, NaI*131
Partner Name Gambogic acid
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression ABCB1 hsa5243
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Down-regulation Expression TP53 hsa7157
In Vitro Model A549/DDP Lung adenocarcinoma Homo sapiens (Human) CVCL_C0W4
Result The two drugs appear to have a synergistic effect on apoptosis of A549/DDP cells.
03. Reference
No. Title Href
1 Role of gambogic acid and NaI131 in A549/DDP cells. Oncol Lett. 2017 Jan;13(1):37-44. doi: 10.3892/ol.2016.5435. Click
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