InterPAD - DETAILS

[2-(aminomethyl)cyclobutyl]methanamine;2-oxidopropanoate;platinum(4+), Lobaplatine, Lobaplatino, Lobaplatinum, UNII-OX5XK1JD8C, Lobaplatine [INN-French], Lobaplatinum [INN-Latin], Lobaplatino [INN-Spanish], NSC619413, NSC 741422, NSC-619413, cis-((trans-1,2-Cyclobutandimethylamine)-(s)-2-oxidopropanoato-platinum(II)), cis-(trans-1,2-Cyclobutanebis(methylamine))((S)-lactato-O(sup 1),O(sup 1))platinum, Platinum, (rel-(1R,2R)-1,2-cyclobutanedimethanamine-kappaN,kappaN')((2S)-2-(hydroxy-kappa-O)propanoato(2-)-kappaO)-, (SP-4-3)-, Platinum,2-cyclobutanedimethanamine-N,N') [2-hydroxypropanoato(2-)-O(1),O(2)]-, (SP-4-3)

No.	Title	Href
1	Effect of combined treatment with lobaplatin and osthole on inducing apoptosis and inhibiting proliferation in human breast cancer MDA-MB-231 cells. Med Oncol. 2021 Nov 27;39(1):16. doi: 10.1007/s12032-021-01609-4.	`Click`

No.

Title

Href

Effect of combined treatment with lobaplatin and osthole on inducing apoptosis and inhibiting proliferation in human breast cancer MDA-MB-231 cells. Med Oncol. 2021 Nov 27;39(1):16. doi: 10.1007/s12032-021-01609-4.

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Name	Lobaplatin
PubChem CID	24202037
Molecular Weight	397.33g/mol
Synonyms	[2-(aminomethyl)cyclobutyl]methanamine;2-oxidopropanoate;platinum(4+), Lobaplatine, Lobaplatino, Lobaplatinum, UNII-OX5XK1JD8C, Lobaplatine [INN-French], Lobaplatinum [INN-Latin], Lobaplatino [INN-Spanish], NSC619413, NSC 741422, NSC-619413, cis-((trans-1,2-Cyclobutandimethylamine)-(s)-2-oxidopropanoato-platinum(II)), cis-(trans-1,2-Cyclobutanebis(methylamine))((S)-lactato-O(sup 1),O(sup 1))platinum, Platinum, (rel-(1R,2R)-1,2-cyclobutanedimethanamine-kappaN,kappaN')((2S)-2-(hydroxy-kappa-O)propanoato(2-)-kappaO)-, (SP-4-3)-, Platinum,2-cyclobutanedimethanamine-N,N') [2-hydroxypropanoato(2-)-O(1),O(2)]-, (SP-4-3)
Drug Type	Small molecule
Formula	C₉H₁₈N₂O₃Pt+₂
SMILES	CC(C(=O)[O-])[O-].C1CC(C1CN)CN.[Pt+4]
InChI	1S/C6H14N2.C3H5O3.Pt/c7-3-5-1-2-6(5)4-8;1-2(4)3(5)6;/h5-6H,1-4,7-8H2;2H,1H3,(H,5,6);/q;-1;+4/p-1
InChIKey	XSMVECZRZBFTIZ-UHFFFAOYSA-M
CAS Number	131374-93-1
TTD ID	D0S4QZ
Toxicity	Organism	Test Type	Route(Dose)
Structure			Download 2D MOL 3D MOL

Pair Name	Osthol, Lobaplatin
Partner Name	Osthol
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	OST enhanced the apoptosis-mediated growth inhibitory effect of lobaplatin on breast cancer cells and has potential for the treatment of breast cancer in the future.