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2-(3,4-dihydroxyphenyl)ethyl (2S-(2alpha,3E,4beta))-3-ethylidene-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate, oleoeuropein, oleoeuropeine, oleuropein

No.	Title	Href
1	Synergistic Anti-Breast-Cancer Effects of Combined Treatment With Oleuropein and Doxorubicin In Vivo. Altern Ther Health Med. 2019 May;25(3):17-24.	`Click`
2	Oleuropein reduces cisplatin resistance in ovarian cancer by targeting apoptotic pathway regulators. Life Sci. 2021 Aug 1;278:119525. doi: 10.1016/j.lfs.2021.119525.	`Click`
3	Oleuropein potentiates anti-tumor activity of cisplatin against HepG2 through affecting proNGF/NGF balance. Life Sci. 2018 Apr 1;198:87-93. doi: 10.1016/j.lfs.2018.02.027.	`Click`

No.

Title

Href

Synergistic Anti-Breast-Cancer Effects of Combined Treatment With Oleuropein and Doxorubicin In Vivo. Altern Ther Health Med. 2019 May;25(3):17-24.

Click

Oleuropein reduces cisplatin resistance in ovarian cancer by targeting apoptotic pathway regulators. Life Sci. 2021 Aug 1;278:119525. doi: 10.1016/j.lfs.2021.119525.

Click

Oleuropein potentiates anti-tumor activity of cisplatin against HepG2 through affecting proNGF/NGF balance. Life Sci. 2018 Apr 1;198:87-93. doi: 10.1016/j.lfs.2018.02.027.

Click

Name	Oleuropein
PubChem CID	5281544
Molecular Weight	540.5g/mol
Synonyms	2-(3,4-dihydroxyphenyl)ethyl (2S-(2alpha,3E,4beta))-3-ethylidene-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-acetate, oleoeuropein, oleoeuropeine, oleuropein
Formula	C₂₅H₃₂O₁₃
SMILES	CC=C1C(C(=COC1OC2C(C(C(C(O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O
InChI	1S/C25H32O13/c1-3-13-14(9-19(29)35-7-6-12-4-5-16(27)17(28)8-12)15(23(33)34-2)11-36-24(13)38-25-22(32)21(31)20(30)18(10-26)37-25/h3-5,8,11,14,18,20-22,24-28,30-32H,6-7,9-10H2,1-2H3/b13-3+/t14-,18+,20+,21-,22+,24-,25-/m0/s1
InChIKey	RFWGABANNQMHMZ-ZCHJGGQASA-N
CAS Number	32619-42-4
ChEMBL ID	CHEMBL1911053
ChEBI ID	CHEBI:7747
Herb ID	HBIN038054
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	NvZhenZi
Use Part	Fruit
Habitat	ZheJiang, JiangSu, HuNan, FuJian, GuangXi, JiangXi, SiChuan
Flavor	Sweet, Bitter
Meridian Tropism	Liver, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Oleaceae 　　　　　-->Genus: Ligustrum 　　　　　　-->Species: Ligustrum lucidum

Chineses Pinyin	QinPi
Use Part	Bark
Habitat	Shaanxi, HeBei, JiLin, LiaoNing
Flavor	Bitter, Astringent
Meridian Tropism	Liver, Gallbladder, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Oleaceae 　　　　　-->Genus: Fraxinus 　　　　　　-->Species: Fraxinus rhynchophylla

Chineses Pinyin	YouGanLan
Use Part	Fruit
Habitat	HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Oleaceae 　　　　　-->Genus: Olea 　　　　　　-->Species: Olea europaea

Chineses Pinyin	GanLan
Use Part	leaf
Habitat	FuJian, SiChuan, GuangDong, YunNan, GuangXi
Flavor	Sweet; Sour; Punkery
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Sapindales 　　　　-->Family: Burseraceae 　　　　　-->Genus: Canarium 　　　　　　-->Species: Canarium album

Pair Name	Oleuropein, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BIRC5	hsa332
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	NFKB1	hsa4790
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
In Vivo Model	The study involved 40 female, nude mice (BALB/c OlaHsd-foxn1),the volume of the tumor increased aggressively, reaching 173 mm3 in the control animals in a time-dependent manner. On the other hand, a sharp drop, to 48.7 mm3, in the volume of the tumor was observed with the 2 drugs combined, a more than 3-fold decrease.
Result	The key findings clearly indicate the synergistic efficacy of DOX with natural and nontoxic OL against breast tumor xenografts.

Pair Name	Oleuropein, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	GDE1	hsa51573
	Down-regulation	Expression	MCL1	hsa4170
	Up-regulation	Expression	TNFRSF10B	hsa8795
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0134
In Vitro Model	A2780/CP70	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0135
Result	These data revealed that oleuropein regulated the expression of the above-mentioned miRNAs in ovarian cancer cells, which potentially resulted in apoptosis induction, cell proliferation inhibition, and cisplatin resistance decline in ovarian cancer cells. To confirm the results of this study, it is suggested that similar experiments be performed in animal models of ovarian cancer.