arachidin-1
| Name | Arachidin-1 | ||
| PubChem CID | 11220670 | ||
| Molecular Weight | 312.4g/mol | ||
| Synonyms |
arachidin-1 |
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| Formula | C₁₉H₂₀O₄ | ||
| SMILES | CC(C)C=CC1=C(C=C(C=C1O)C=CC2=CC(=C(C=C2)O)O)O | ||
| InChI | 1S/C19H20O4/c1-12(2)3-7-15-17(21)10-14(11-18(15)22)5-4-13-6-8-16(20)19(23)9-13/h3-12,20-23H,1-2H3/b5-4+,7-3+ | ||
| InChIKey | YOWZUITYQFPEGQ-JLVHPEPXSA-N | ||
| CAS Number | 98391-38-9 | ||
| ChEMBL ID | CHEMBL2230262 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | HuaSheng | ||
| Use Part | Seed | ||
| Habitat | China | ||
| Flavor | Sweet | ||
| Meridian Tropism | Spleen; Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Arachis
-->Species: Arachis hypogaea
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| Pair Name | Arachidin-1, Paclitaxel | |||
| Partner Name | Paclitaxel | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induced-->Mitochondrial oxidative stress | |||
| Gene Regulation | Down-regulation | Expression | BIRC5 | hsa332 |
| Up-regulation | Cleavage | CASP7 | hsa840 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| MDA-MB-436 | Invasive breast carcinoma | Homo sapiens (Human) | CVCL_0623 | |
| Result | A-1 in combination with Pac inhibited cell proliferation, induced apoptosis through mitochondrial oxidative stress, and reduced TNBC spheroid growth. These findings underscore the impactful effects of the prenylated stilbenoid A-1 as a novel adjuvant for Pac chemotherapy in TNBC treatment. | |||
