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9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-, Banisterine, Harmine, Leucoharmine, Telepathine, Yageine

No.	Title	Href
1	Harmine Augments the Cytotoxic and Anti-invasive Potential of Temozolomide Against Glioblastoma Multiforme Cells. Jundishapur J Nat Pharm Prod. 2021. doi:10.5812/jjnpp.115464.	`Click`
2	Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer. Oncol Lett. 2016 Aug;12(2):983-988. doi: 10.3892/ol.2016.4696.	`Click`

No.

Title

Href

Harmine Augments the Cytotoxic and Anti-invasive Potential of Temozolomide Against Glioblastoma Multiforme Cells. Jundishapur J Nat Pharm Prod. 2021. doi:10.5812/jjnpp.115464.

Click

Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer. Oncol Lett. 2016 Aug;12(2):983-988. doi: 10.3892/ol.2016.4696.

Click

Name	Harmine
PubChem CID	5280953
Molecular Weight	212.25g/mol
Synonyms	9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-, Banisterine, Harmine, Leucoharmine, Telepathine, Yageine
Formula	C₁₃H₁₂N₂O
SMILES	CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
InChI	1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
InChIKey	BXNJHAXVSOCGBA-UHFFFAOYSA-N
CAS Number	442-51-3
ChEMBL ID	CHEMBL269538
ChEBI ID	CHEBI:28121
Herb ID	HBIN028803
Drug Bank ID	DB07919
KEGG ID	C06538
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	LuoTuoPeng
Use Part	Whole herb
Habitat	NeiMengGu, NingXia, GanSu, XinJiang, XiZang
Flavor	Sour; Sweet
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Sapindales 　　　　-->Family: Nitrariaceae 　　　　　-->Genus: Peganum 　　　　　　-->Species: Peganum harmala

Pair Name	Harmine, Temozolomide
Partner Name	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Gene Regulation	Down-regulation	Expression	MMP2	hsa4313
Gene Regulation	Down-regulation	Expression	MMP9	hsa4318
In Vitro Model	T98G	Glioblastoma	Homo sapiens (Human)	CVCL_0556
Result	Harmine Augments the Cytotoxic and Anti-invasive Potential of Temozolomide Against Glioblastoma Multiforme Cells

Pair Name	Harmine, Paclitaxel
Partner Name	Paclitaxel
Disease Info	[ICD-11: 2B72.Z]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Expression	PCNA	hsa5111
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Expression	TP53	hsa7157
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	SMAD4	hsa4089
	Down-regulation	Expression	TNF	hsa7124
	Down-regulation	Expression	NFKB1	hsa4790
	Down-regulation	Expression	FN1	hsa2335
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	CTNNB1	hsa1499
	Down-regulation	Expression	TWIST1	hsa7291
	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
In Vivo Model	The mice were subcutaneously injected into the left axillary space with 0.1 ml of cell suspension containing 4-6×10⁶ SGC-7901 cells.
Result	Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer