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  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Mangiferin
PubChem CID 5281647
Molecular Weight 422.3g/mol
Synonyms

2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one, 9H-xanthen-9-one, 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-, alpizarin, chinonin, mangiferin
Formula C₁₉H₁₈O₁₁
SMILES C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)C4C(C(C(C(O4)CO)O)O)O)O
InChI 1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1
InChIKey AEDDIBAIWPIIBD-ZJKJAXBQSA-N
CAS Number 4773-96-0
ChEMBL ID CHEMBL464825
ChEBI ID CHEBI:6682
Herb ID HBIN034394
KEGG ID C10077
Toxicity Organism Test Type Route(Dose)
rat LD50 intraperitoneal(165 mg/kg)
mouse LD50 intraperitoneal(254 mg/kg)
rat LD50 oral(322 mg/kg)
Structure 2D-img
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2D MOL 3D MOL
02. Source Information of Phytochemical
(1) Anemarrhena asphodeloides Cold
Chineses Pinyin ZhiMu
Use Part Rhizome
Habitat HeiLongJiang, JiLin, LiaoNing, NeiMengGu, HeBei, HeNan, ShanDong, Shaanxi, GanSu
Flavor Bitter, Sweet
Meridian Tropism Lung, Stomach, Kidney
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Asparagales
　　　　-->Family: Asparagaceae
　　　　　-->Genus: Anemarrhena
　　　　　　-->Species: Anemarrhena asphodeloides
(2) Urena lobataL Cold
Chineses Pinyin DiTaoHua
Use Part Root, Whole Grass
Habitat HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan
Flavor Sweet, Bland
Meridian Tropism Spleen, Lung
(3) Artemisia scoparia Cold
Chineses Pinyin YinChen
Use Part Whole Herb
Habitat China
Flavor Bitter, Pungent
Meridian Tropism Spleen, Stomach, Liver, Gallbladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Asterales
　　　　-->Family: Asteraceae
　　　　　-->Genus: Artemisia
　　　　　　-->Species: Artemisia scoparia
(4) Swertia mussotii Cool
Chineses Pinyin ChuanXiZhangYaCai
Use Part Whole Herb
Habitat XiZang, YunNan, SiChuan, GanSu, QingHai, NingXia, XinJiang, QingHai, GuiZhou, ChongQing
Flavor Bitter
Meridian Tropism Heart, Liver
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Gentianales
　　　　-->Family: Gentianaceae
　　　　　-->Genus: Swertia
　　　　　　-->Species: Swertia mussotii
(5) Swertia pseudochinensis Cold
Chineses Pinyin DangYao
Use Part Whole Herb
Habitat China
Flavor Bitter
Meridian Tropism Liver, Stomach, Large intestine
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Gentianales
　　　　-->Family: Gentianaceae
　　　　　-->Genus: Swertia
　　　　　　-->Species: Swertia pseudochinensis
(6) Gentiana manshurica Cold
Chineses Pinyin LongDan
Use Part Root, Rhizome
Habitat HeiLongJiang, JiLin, LiaoNing
Flavor Bitter
Meridian Tropism Liver, Gallbladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Gentianales
　　　　-->Family: Gentianaceae
　　　　　-->Genus: Gentiana
　　　　　　-->Species: Gentiana manshurica
(7) Gossampinus malabarica Cool
Chineses Pinyin MuMianHua
Use Part Flower
Habitat GuangDong, GuangXi, FuJian, TaiWan, YunNan
Flavor Sweet, Bland
Meridian Tropism Large intestine
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Malvales
　　　　-->Family: Malvaceae
　　　　　-->Genus: Gossampinus
　　　　　　-->Species: Gossampinus malabarica
(8) Mangifera indica Even
Chineses Pinyin MangGuoYe
Use Part Leaf
Habitat FuJian, TaiWan, GuangDong, HaiNan, GuangXi, YunNan
Flavor Mildly sour
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Sapindales
　　　　-->Family: Anacardiaceae
　　　　　-->Genus: Mangifera
　　　　　　-->Species: Mangifera indica
(9) Pyrrosia sheareri Cool
Chineses Pinyin BeiJingShiWei
Habitat HeBei, ShanDong, HuBei, ShanXi, Shaanxi, NeiMengGu
Flavor Bitter, Sweet
Meridian Tropism Lung, Bladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Polypodiales
　　　　-->Family: Polypodiaceae
　　　　　-->Genus: Pyrrosia
　　　　　　-->Species: Pyrrosia sheareri
(10) Drynaria fortunei Warm
Chineses Pinyin GuSuiBu
Use Part Rhizome
Habitat ZheJiang, FuJian, TaiWan
Flavor Bitter
Meridian Tropism Liver, Kidney
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Polypodiales
　　　　-->Family: Polypodiaceae
　　　　　-->Genus: Drynaria
　　　　　　-->Species: Drynaria fortunei
(11) Pyrrosia sheareri Cold
Chineses Pinyin ShiWei
Use Part Leaf
Habitat China
Flavor Sweet, Bitter
Meridian Tropism Lung, Bladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Polypodiales
　　　　-->Family: Polypodiaceae
　　　　　-->Genus: Pyrrosia
　　　　　　-->Species: Pyrrosia sheareri
(12) Crocus sativus Even
Chineses Pinyin ZangHongHua
Use Part Stigma
Habitat ZheJiang, JiangSu, ShangHai
Flavor Sweet
Meridian Tropism Heart, Liver
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Asparagales
　　　　-->Family: Iridaceae
　　　　　-->Genus: Crocus
　　　　　　-->Species: Crocus sativus
(13) Iris domestica Cold
Chineses Pinyin SheGan
Use Part Rhizome
Habitat HuBei, JiangSu, HeNan, AnHui
Flavor Bitter
Meridian Tropism Lung
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Asparagales
　　　　-->Family: Iridaceae
　　　　　-->Genus: Iris
　　　　　　-->Species: Iris domestica
(14) Prunus amygdalus Even
Chineses Pinyin BianTao
Use Part Fruit
Habitat XinJiang, Shaanxi, GanSu
Flavor Bitter, Sweet
Meridian Tropism Heart, Liver, Large intestine
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Rosales
　　　　-->Family: Rosaceae
　　　　　-->Genus: Prunus
　　　　　　-->Species: Prunus amygdalus
(15) Gentiana scabra Cold
Chineses Pinyin CuCaoLongDan
Use Part Root, Rhizome
Habitat HeiLongJiang, JiLin, LiaoNing, NeiMengGu, HeBei, ShanDong, JiangSu, AnHui, ZheJiang, FuJian, JiangXi, HuNan, HuBei, GuiZhou, SiChuan, GuangDong, GuangXi
Flavor Bitter
Meridian Tropism Liver, Gallbladder
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Gentianales
　　　　-->Family: Gentianaceae
　　　　　-->Genus: Gentiana
　　　　　　-->Species: Gentiana scabra
(16) Pyrrosia sheareri Cold
Chineses Pinyin LuShanShiWei
Use Part Leaf
Habitat GuiZhou, SiChuan, XiZang, GuangXi, GuangDong, HuNan, HuBei, ZheJiang, AnHui, JiangXi, FuJian, TaiWan
Flavor Bitter, Sweet
Meridian Tropism Lung, Bladder, Small intestine
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Polypodiales
　　　　-->Family: Polypodiaceae
　　　　　-->Genus: Pyrrosia
　　　　　　-->Species: Pyrrosia sheareri
(17) Salacia prinoides Unknown
Chineses Pinyin WuCengLong
Use Part Root, Stem
Habitat GuangDong, GuangXi
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Celastrales
　　　　-->Family: Celastraceae
　　　　　-->Genus: Salacia
　　　　　　-->Species: Salacia chinensis
(18) Pyrrosia petiolosa Cold
Chineses Pinyin YouBingShiWei
Use Part Leaf
Flavor Bitter, Sweet
Species
>Kingdom: Viridiplantae
　-->Phylum: Streptophyta
　　-->Class: Equisetopsida
　　　-->Order: Polypodiales
　　　　-->Family: Polypodiaceae
　　　　　-->Genus: Pyrrosia
　　　　　　-->Species: Pyrrosia petiolosa
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Drug(s) whose efficacy can be enhanced by this phytochemical
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Combination Pair ID: 454
Ref_2
Pair Name Mangiferin, Doxorubicin
Partner Name Doxorubicin
Disease Info [ICD-11: 2A83] Multiple myeloma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in sub-G1 phase
Gene Regulation Down-regulation Expression BCL-xL hsa598
Down-regulation Expression BIRC5 hsa332
Up-regulation Activity CASP3 hsa836
Down-regulation Expression NFKB1 hsa4790
Up-regulation Expression PMAIP1 hsa5366
Up-regulation Expression TP53 hsa7157
Down-regulation Expression XIAP hsa331
In Vitro Model IM-9 Healthy Homo sapiens (Human) CVCL_1305
RPMI-8226 Plasma cell myeloma Homo sapiens (Human) CVCL_0014
Result Our findings suggest that the combination of mangiferin and an anticancer drug could be used as a new regime for the treatment of MM.
Combination Pair ID: 868
Ref_3
Pair Name Mangiferin, Oxaliplatin
Partner Name Oxaliplatin
Disease Info [ICD-11: 2B91] Colorectal cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression CASP3 hsa836
Down-regulation Expression CDH13 hsa1012
In Vitro Model HT-29 Colon adenocarcinoma Homo sapiens (Human) CVCL_0320
Result The present study indicates that mangiferin in combination with oxaliplatin favours apoptotic cell death and thereby improves the efficacy of oxaliplatin in vitro. In addition, combination therapy with mangiferin may also counteract the development of resistance in cancer cell lines.
Drug(s) whose toxicity can be decreased by this phytochemical
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Combination Pair ID: 453
Ref_1
Pair Name Mangiferin, Cisplatin
Partner Name Cisplatin
Disease Info Nephrotoxicity Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Down-regulation Expression CAPN1 hsa823
Down-regulation Cleavage CASP12 hsa100506742
Down-regulation Cleavage CASP3 hsa836
Up-regulation Expression HMOX1 hsa3162
Down-regulation Expression MYC hsa4609
Up-regulation Expression NFE2L2 hsa4780
Up-regulation Expression PIK3CA hsa5290
Up-regulation Expression SOD2 hsa6648
In Vitro Model MCF-7 Invasive breast carcinoma of no special type Homo sapiens (Human) CVCL_0031
SK-RC-45 Clear cell renal cell carcinoma Homo sapiens (Human) CVCL_4016
EAC-E2G8 Malignant neoplasms of the mouse mammary gland Mus musculus (Mouse) CVCL_WJ08
In Vivo Model Four weeks old male swiss albino mice were used for this study.
Result The study reveals a mechanistic basis of mangiferin action against cisplatin induced nephrotoxicity. Since Mangiferin shows synergistic anticancer activity with cisplatin, it can be considered as a promising drug candidate, to be used in combination with cisplatin.
04. Reference
No. Title Href
1 Mangiferin Ameliorates Cisplatin Induced Acute Kidney Injury by Upregulating Nrf-2 via the Activation of PI3K and Exhibits Synergistic Anticancer Activity With Cisplatin. Front Pharmacol. 2018 Jun 18;9:638. doi: 10.3389/fphar.2018.00638. Click
2 Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway. Int J Oncol. 2016 Jun;48(6):2704-12. doi: 10.3892/ijo.2016.3470. Click
3 Combination treatment with oxaliplatin and mangiferin causes increased apoptosis and downregulation of NFκB in cancer cell lines. Afr J Tradit Complement Altern Med. 2011;8(2):177-84. doi: 10.4314/ajtcam.v8i2.63206. Click
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