InterPAD - DETAILS

acteoside, glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-, 4-(3-(3,4-dihydroxyphenyl)-2-propenoate), (E)-beta-D-, kusaginin, TJC 160, TJC-160, verbascoside

No.	Title	Href
1	Acteoside attenuates TSLP-induced mast cell proliferation via down-regulating MDM2. Int Immunopharmacol. 2015 May;26(1):23-9. doi: 10.1016/j.intimp.2015.03.003.	`Click`
2	Acteoside as a potential therapeutic option for primary hepatocellular carcinoma: a preclinical study. BMC Cancer. 2020 Sep 29;20(1):936. doi: 10.1186/s12885-020-07447-3.	`Click`
3	Synergistic anticancer effect of acteoside and temozolomide-based glioblastoma chemotherapy. Int J Mol Med. 2019 Mar;43(3):1478-1486. doi: 10.3892/ijmm.2019.4061.	`Click`

No.

Title

Href

Acteoside attenuates TSLP-induced mast cell proliferation via down-regulating MDM2. Int Immunopharmacol. 2015 May;26(1):23-9. doi: 10.1016/j.intimp.2015.03.003.

Click

Acteoside as a potential therapeutic option for primary hepatocellular carcinoma: a preclinical study. BMC Cancer. 2020 Sep 29;20(1):936. doi: 10.1186/s12885-020-07447-3.

Click

Synergistic anticancer effect of acteoside and temozolomide-based glioblastoma chemotherapy. Int J Mol Med. 2019 Mar;43(3):1478-1486. doi: 10.3892/ijmm.2019.4061.

Click

Name	Acteoside
PubChem CID	5281800
Molecular Weight	624.6g/mol
Synonyms	acteoside, glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-, 4-(3-(3,4-dihydroxyphenyl)-2-propenoate), (E)-beta-D-, kusaginin, TJC 160, TJC-160, verbascoside
Formula	C₂₉H₃₆O₁₅
SMILES	CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)CO)OCCC4=CC(=C(C=C4)O)O)O)O)O)O
InChI	1S/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-/m0/s1
InChIKey	FBSKJMQYURKNSU-ZLSOWSIRSA-N
CAS Number	61276-17-3
ChEMBL ID	CHEMBL444478
ChEBI ID	CHEBI:132853
Herb ID	HBIN014630
Drug Bank ID	DB12996
KEGG ID	C10501
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	MiMengHua
Use Part	Flower Bud, Inflorescence
Habitat	ShanXi, Shaanxi, GanSu, JiangSu, AnHui, FuJian, HeNan, HuBei, HuNan, GuangDong, GuangXi, SiChuan, GuiZhou, YunNan, XiZang
Flavor	Sweet
Meridian Tropism	Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Scrophulariaceae 　　　　　-->Genus: Buddleja 　　　　　　-->Species: Buddleja officinalis

Chineses Pinyin	HouPu
Use Part	Bark
Habitat	SiChuan, HuBei
Flavor	Bitter, Pungent
Meridian Tropism	Spleen, Stomach, Lung, Large intestine
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Magnoliales 　　　　-->Family: Magnoliaceae 　　　　　-->Genus: Magnolia 　　　　　　-->Species: Magnolia officinalis

Chineses Pinyin	DiHuang
Use Part	Dried root
Habitat	HeNan, ZheJiang, JiangSu, AnHui, ShanDong, HeBei, LiaoNing, ShanXi, Shaanxi, NeiMengGu, HuNan, HuBei, SiChuan
Flavor	Sweet
Meridian Tropism	Heart; Liver; Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Lamiales 　　　　-->Family: Orobanchaceae 　　　　　-->Genus: Rehmannia 　　　　　　-->Species: Rehmannia glutinosa

Pair Name	Acteoside, Sorafenib
Partner Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Inhibition-->Angiogenesis
Gene Regulation	Down-regulation	Expression	KLK1	hsa3816
	Down-regulation	Expression	KLK10	hsa5655
	Down-regulation	Expression	KLK2	hsa3817
	Down-regulation	Expression	KLK4	hsa9622
	Down-regulation	Expression	KLK9	hsa284366
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	BEL-7404	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_6568
	HLF	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_2947
	JHH-7	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_2805
In Vivo Model	The BEL7404 cell suspensions were prepared (3×10⁶ cells) and injected subcutaneously into the right flank of athymic nude mice.
Result	Acteoside exerts an antitumor effect possibly through its up-regulation of p53 levels as well as inhibition of KLK expression and angiogenesis. Acteoside could be useful as an adjunct in the treatment of advanced HCC in the clinic.

Pair Name	Acteoside, Temozolomide
Partner Name	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Induction-->Apoptosis and autophagy
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Phosphorylation	MAPK14	hsa1432
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Up-regulation	Expression	RAB7A	hsa7879
	Up-regulation	Expression	SQSTM1	hsa8878
	Up-regulation	Phosphorylation	TP53	hsa7157
In Vitro Model	C6	Rat malignant glioma	Rattus norvegicus (Rat)	CVCL_0194
Result	It was also determined that TMZ + acteoside induced apoptosis and autophagy through the mitogen‑activated protein kinase signaling pathway. These findings suggest that acteoside has beneficial effects on TMZ‑based glioblastoma therapy.

Pair Name	Acteoside, Thymic stromal lymphopoietin
Partner Name	Thymic stromal lymphopoietin
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	IL1B	hsa3553
	Down-regulation	Expression	IL6	hsa3569
	Down-regulation	Expression	MDM2	hsa4193
	Down-regulation	Expression	TNF	hsa7124
In Vitro Model	HMC-1	Mast cell leukemia	Homo sapiens (Human)	CVCL_0003
Result	These results indicate that acteoside is a specific regulator of MDM2 activation in TSLP-stimulated mast cells, which indicates its potential use for the treatment of mast cell-mediated inflammatory diseases.