deoxyelephantopin
| Name | Deoxyelephantopin | ||
| PubChem CID | 6325056 | ||
| Molecular Weight | 344.4g/mol | ||
| Synonyms |
deoxyelephantopin |
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| Formula | C₁₉H₂₀O₆ | ||
| SMILES | CC1=CC2C(C(CC3=CC(C1)OC3=O)OC(=O)C(=C)C)C(=C)C(=O)O2 | ||
| InChI | 1S/C19H20O6/c1-9(2)17(20)24-15-8-12-7-13(23-19(12)22)5-10(3)6-14-16(15)11(4)18(21)25-14/h6-7,13-16H,1,4-5,8H2,2-3H3/b10-6+/t13-,14-,15+,16+/m1/s1 | ||
| InChIKey | JMUOPRSXUVOHFE-GZZMZBIISA-N | ||
| ChEMBL ID | CHEMBL5272075 | ||
| ChEBI ID | CHEBI:4409 | ||
| Herb ID | HBIN023361 | ||
| KEGG ID | C09388 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | DiDanCao | ||
| Use Part | Root, Rhizome | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, NeiMengGu | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver, Gallbladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Elephantopus
-->Species: Elephantopus scaber
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| Chineses Pinyin | ChuanXinLian | ||
| Use Part | Aerial Parts | ||
| Habitat | JiangXi, HuNan, FuJian, GuangDong, GuangXi, SiChuan | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart, Lung, Large intestine, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Lamiales
-->Family: Acanthaceae
-->Genus: Andrographis
-->Species: Andrographis paniculata
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| Chineses Pinyin | ZiSuiHuai | ||
| Use Part | Leaf | ||
| Habitat | HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, NingXia, XinJiang, ShanDong, AnHui, JiangSu, HeNan, HuBei, GuangXi, SiChuan | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Amorpha
-->Species: Amorpha fruticosa
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| Pair Name | Deoxyelephantopin, Gemcitabine | |||
| Partner Name | Gemcitabine | |||
| Disease Info | [ICD-11: 2C10.Z] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induced-->Oxidative Stress | |||
| Gene Regulation | Down-regulation | Expression | NFKB1 | hsa4790 |
| In Vitro Model | BxPC-3 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0186 |
| CFPAC-1 | Cystic fibrosis | Homo sapiens (Human) | CVCL_1119 | |
| In Vivo Model | To confirm the inhibition of tumor growth by DET and GEM, 100 μL of BxPC-3 cell suspension (5×10⁷ cells/mL) was administered subcutaneously into the right middle armpit of mice to establish subcutaneous tumors. | |||
| Result | It is possible that DET could be developed as a single agent or combined with conventional chemotherapy drugs to improve the treatment of pancreatic cancer. | |||
| Pair Name | Deoxyelephantopin, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C30] | Melanoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Expression | CDK1 | hsa983 |
| Down-regulation | Expression | CCNA2 | hsa890 | |
| Down-regulation | Expression | CCND1 | hsa595 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| In Vitro Model | B16 | Mouse melanoma | Mus musculus (Mouse) | CVCL_F936 |
| In Vivo Model | The other six groups of mice were intravenously (i.v.) injected with 1×10⁵ B16 cells in 200 μl PBS through the tail vein at day 0. | |||
| Result | The CP and DET combination may be an effective intervention for melanoma with reduced side effects. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity. Phytomedicine. 2019 Mar 15;56:194-206. doi: 10.1016/j.phymed.2018.11.005. | Click |
| 2 | Deoxyelephantopin induces apoptosis via oxidative stress and enhances gemcitabine sensitivity in vitro and in vivo through targeting the NF-κB signaling pathway in pancreatic cancer. Aging (Albany NY). 2020 Jun 11;12(11):11116-11138. doi: 10.18632/aging.103327. | Click |
