genipin
| Name | Genipin | ||
| PubChem CID | 442424 | ||
| Molecular Weight | 226.23g/mol | ||
| Synonyms |
genipin |
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| Formula | C₁₁H₁₄O₅ | ||
| SMILES | COC(=O)C1=COC(C2C1CC=C2CO)O | ||
| InChI | 1S/C11H14O5/c1-15-10(13)8-5-16-11(14)9-6(4-12)2-3-7(8)9/h2,5,7,9,11-12,14H,3-4H2,1H3/t7-,9-,11-/m1/s1 | ||
| InChIKey | AZKVWQKMDGGDSV-BCMRRPTOSA-N | ||
| CAS Number | 6902-77-8 | ||
| ChEMBL ID | CHEMBL459016 | ||
| ChEBI ID | CHEBI:5298 | ||
| Herb ID | HBIN027445 | ||
| KEGG ID | C09780 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | BaiHuaSheSheCao | ||
| Use Part | Whole Herb With Root | ||
| Habitat | FuJian, GuangDong, Hongkong , GuangXi, HaiNan, AnHui, YunNan, Nepal , Japan | ||
| Flavor | Sweet, Bland | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Gentianales
-->Family: Rubiaceae
-->Genus: Scleromitrion
-->Species: Scleromitrion diffusum
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| Chineses Pinyin | ZhiZi | ||
| Use Part | Ripe fruit | ||
| Habitat | JiangXi, HuBei, HuNan, ZheJiang, FuJian, SiChuan | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart; Lung; Triple Energizers | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Gentianales
-->Family: Rubiaceae
-->Genus: Gardenia
-->Species: Gardenia jasminoides
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| Pair Name | Genipin, Oxaliplatin | |||
| Partner Name | Oxaliplatin | |||
| Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Up-regulation | Expression | DRAM1 | hsa55332 |
| Up-regulation | Expression | MAP1LC3A | hsa84557 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 |
| MKN45 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0434 | |
| MKN28 | Gastric tubular adenocarcinoma | Homo sapiens (Human) | CVCL_1416 | |
| Result | We showed that genipin increases the oxaliplatin-induced cell death via p53-DRAM autophagy, we suggest that genipin is a sensitizer of oxaliplatin. | |||
| Pair Name | Genipin, Everolimus | |||
| Partner Name | Everolimus | |||
| Disease Info | [ICD-11: 2C10] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induction-->Proliferation | |||
| Gene Regulation | Up-regulation | Expression | AKT1 | hsa207 |
| Up-regulation | Expression | BECN1 | hsa8678 | |
| Up-regulation | Expression | MTOR | hsa2475 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Up-regulation | Expression | UCP2 | hsa7351 | |
| In Vitro Model | PaCa-44 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_7087 |
| PaCa-3 | Pancreatic carcinoma | Homo sapiens (Human) | CVCL_4011 | |
| PANC-1 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0480 | |
| MIA PaCa-2 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0428 | |
| T3M-4 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_4056 | |
| In Vivo Model | PaCa44 cells (1×10⁶ cells/mice) were s.c. injected into the dorsal flank of six nude female mice for each condition (5 weeks of age; Charles River Laboratories, Inc.). | |||
| Result | These results reveal novel mechanisms through which UCP2 promotes cancer cell proliferation and support the combined inhibition of UCP2 and of Akt/mTOR pathway as a novel therapeutic strategy in the treatment of pancreatic adenocarcinoma. | |||
| Pair Name | Genipin, Oxaliplatin | |||
| Partner Name | Oxaliplatin | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Endoplasmic reticulum stress | |||
| Gene Regulation | Up-regulation | Expression | BCL2L11 | KEGG ID N.A. |
| Up-regulation | Expression | BIM | hsa10018 | |
| Up-regulation | Expression | ESR1 | hsa2099 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| Down-regulation | Activity | SOD3 | hsa6649 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| DLD-1 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0248 | |
| Result | These findings suggest that genipin may be a novel agent for increasing the sensitivity of oxaliplatin against colorectal cancer. The combination of oxaliplatin and genipin hold significant therapeutic potential with minimal adverse effects. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Genipin Enhances the Therapeutic Effects of Oxaliplatin by Upregulating BIM in Colorectal Cancer. Mol Cancer Ther. 2019 Apr;18(4):751-761. doi: 10.1158/1535-7163.MCT-18-0196. | Click |
| 2 | Genipin increases oxaliplatin-induced cell death through autophagy in gastric cancer. J Cancer. 2020 Jan 1;11(2):460-467. doi: 10.7150/jca.34773. | Click |
| 3 | UCP2 inhibition induces ROS/Akt/mTOR axis: Role of GAPDH nuclear translocation in genipin/everolimus anticancer synergism. Free Radic Biol Med. 2017 Dec;113:176-189. doi: 10.1016/j.freeradbiomed.2017.09.022. | Click |
