Pair Name	Anacardic Acid, Bortezomib
Phytochemical	Anacardic Acid
Drug	Bortezomib
Disease Info	[ICD-11: 2A83]	Multiple myeloma		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	The results of the present study suggest that AA/Bor combination may be a potential therapeutic strategy for MM treatment.

Pair Name	Betulinic Acid, Sorafenib
Phytochemical	Betulinic Acid
Drug	Sorafenib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	We showed that combination therapy with low concentrations of sorafenib and betulinic acid had the capacity to induce high levels of cell death and abolish clonogenic activity in some NSCLC cell lines regardless of KRAS mutations.

Pair Name	Casticin, TNF-related apoptosis inducing ligand
Phytochemical	Casticin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Casticin enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and the upregulation of DR5 receptors through actions on the ROS-ER stress-CHOP pathway.

Pair Name	Decursin, TNF-related apoptosis inducing ligand
Phytochemical	Decursin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	ROS generation by decursin selectively activated the PERK/ATF4 axis of the endoplasmic reticulum stress signalling pathway, leading to enhanced TRAIL sensitivity in TRAIL-resistant NSCLC cell lines, partly via up-regulation of DR5.

Pair Name	Fangchinoline, Everolimus
Phytochemical	Fangchinoline
Drug	Everolimus
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Firstly link CHOP to Notch 3/c-MYC axis-dependent apoptosis and provide the Notch 3/c-MYC/CHOP activation as a promising strategy for mTOR-targeted combination therapy in lung cancer treatment.

Pair Name	Licochalcone B, TNF-related apoptosis inducing ligand
Phytochemical	Licochalcone B
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	LCB exhibits cytotoxic activity through modulation of the Akt/mTOR, ER stress and MAPK pathways in HCC cells and effectively enhances TRAIL sensitivity through the upregulation of DR5 expression in ERK- and JNK-dependent manner. Combination therapy with LCB and TRAIL may be an alternative treatment strategy for HCC.

Pair Name	Medicarpin, TNF-related apoptosis inducing ligand
Phytochemical	Medicarpin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B33.1]	Myeloid leukemia		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

Pair Name	Phenethyl isothiocyanate, Gefitinib
Phytochemical	Phenethyl isothiocyanate
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	We explored the prospect of PEITC in improving the efficacy of targeted drug therapy and demonstrated the synergistic effects and underlined mechanisms of PEITC combined with Gefitinib in NSCLC cells treatment. This study provided useful information for developing novel therapy strategies by combination treatment of PEITC with targeted drugs.

Pair Name	Piperlongumine, Bortezomib
Phytochemical	Piperlongumine
Drug	Bortezomib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Piperlongumine and bortezomib synergically inhibit cholangiocarcinoma via ER stress-induced cell death

Pair Name	Piperlongumine, HSP90 inhibitors
Phytochemical	Piperlongumine
Drug	HSP90 inhibitors
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells

Pair Name	Pristimerin, Sorafenib
Phytochemical	Pristimerin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Pristimerin synergistically sensitizes conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells to sorafenib through endoplasmic reticulum stress and ROS generation by modulating Akt/FoxO1/p27kip1 signaling pathway

Pair Name	Pterostilbene, TNF-related apoptosis inducing ligand
Phytochemical	Pterostilbene
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Activity
Result	Pterostilbene enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistance triple negative breast cancer cells

Pair Name	Resveratrol, Cisplatin
Phytochemical	Resveratrol
Drug	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	These results indicated that RES is a promising adjuvant for DDP during GC chemotherapy.

Pair Name	Shogaol, Gefitinib
Phytochemical	Shogaol
Drug	Gefitinib
Disease Info	[ICD-11: 2C73]	Ovarian Cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Our results suggest that 6-shogaol exerts a potential anti-cancer effect in ovarian cancer and combination treatment with 6-shogaol and gefitinib may provide a novel anti-tumor therapeutic strategy in gefitinib-resistant ovarian cancer.

Pair Name	Sulforaphane, CB-5083
Phytochemical	Sulforaphane
Drug	CB-5083
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	The combination of Sulforaphane and CB-5083 may be a useful treatment strategy to combat CB-5083 resistance.

Pair Name	Sulforaphene, Photodynamic therapy
Phytochemical	Sulforaphene
Drug	Photodynamic therapy
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	This study could be useful in the improvement of therapies for human cervical and other types of cancers.

Pair Name	Tannic acid, Cisplatin
Phytochemical	Tannic acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	The combination of TA and CDDP may produce synergistic antitumoral effects mediated by the PERK-ATF4-CHOP apoptotic axis, suggesting a novel adjuvant treatment for lung cancer.

Pair Name	Ursodiol, Bortezomib
Phytochemical	Ursodiol
Drug	Bortezomib
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Ursodeoxycholic Acid Inhibits Glioblastoma Progression via Endoplasmic Reticulum Stress Related Apoptosis and Synergizes with the Proteasome Inhibitor Bortezomib

Pair Name	Withaferin A, Fluorouracil
Phytochemical	Withaferin A
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Synergistic antitumor effect of 5-fluorouracil and withaferin-A induces endoplasmic reticulum stress-mediated autophagy and apoptosis in colorectal cancer cells

Pair Name	Zerumbone, Celecoxib
Phytochemical	Zerumbone
Drug	Celecoxib
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Our results provide novel insights into the role of ATF3 as an essential transcription factor for p53-independent DR5 induction upon both ZER and CCB treatment, and this may be a useful biomarker for TRAIL-based anticancer therapy.

Pair Name	Honokiol, Paclitaxel
Phytochemical	Honokiol
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	DNA damage-inducible transcript 3 protein		Expression
Result	Synergistic killing effect of paclitaxel and honokiol in non-small cell lung cancer cells through paraptosis induction