Pair Name	Artesunate, Fluorouracil
Phytochemical Name	Artesunate
Anticancer drug Name	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Our findings point to the crucial treatment effect of Arte on inflammation, intestinal cell senescence, and CRC cell proliferation and offer a new option for CRC treatment.

Pair Name	Magnoflorine, Doxorubicin
Phytochemical Name	Magnoflorine
Anticancer drug Name	Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways

Pair Name	Paeonol, Epirubicin
Phytochemical Name	Paeonol
Anticancer drug Name	Epirubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Expression
Result	These findings suggest that combination of Paeonol and Epirubicin is potentially applicable for breast cancer treatment.

Pair Name	Resveratrol, Cisplatin
Phytochemical Name	Resveratrol
Anticancer drug Name	Cisplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Expression
Result	Combination therapy of cisplatin and resveratrol to induce cellular aging in gastric cancer cells: Focusing on oxidative stress, and cell cycle arrest

Pair Name	Rutin, Oxaliplatin
Phytochemical Name	Rutin
Anticancer drug Name	Oxaliplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	P38 Signal Transduction Pathway Has More Cofactors on Apoptosis of SGC-7901 Gastric Cancer Cells Induced by Combination of Rutin and Oxaliplatin

Pair Name	Withaferin A, Oxaliplatin
Phytochemical Name	Withaferin A
Anticancer drug Name	Oxaliplatin
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	These results support the notion that combination treatment with oxaliplatin and WA could facilitate development of an effective strategy for PC treatment.

Pair Name	(S)-10-Hydroxycamptothecin, Crizotinib
Phytochemical	(S)-10-Hydroxycamptothecin
Drug	Crizotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells

Pair Name	Acteoside, Temozolomide
Phytochemical	Acteoside
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	It was also determined that TMZ + acteoside induced apoptosis and autophagy through the mitogen‑activated protein kinase signaling pathway. These findings suggest that acteoside has beneficial effects on TMZ‑based glioblastoma therapy.

Pair Name	Alantolactone, Oxaliplatin
Phytochemical	Alantolactone
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	These results suggest that the combination treatment with ALT and oxaliplatin may become a potential therapeutic strategy for colon cancer.

Pair Name	Artesunate, Cisplatin
Phytochemical	Artesunate
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	ART exhibited significant anti-tumor effect on A549 cells and this efficiency could be enhanced by combination with CIS

Pair Name	Baicalein, Cisplatin
Phytochemical	Baicalein
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Treatment with baicalein improved the sensitivity of ovarian cancer cells to cisplatin and inhibited cell proliferation, metastasis and tumor growth

Pair Name	Berbamine, Cisplatin
Phytochemical	Berbamine
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	These findings indicate that Ber might be a promising adjuvant for enhancing the cancer cell killing effect of chemotherapy via the inhibition of autophagy. In this process, Nox2 might be a significant mediator of Ber-induced aberrant lysosomal acidification.

Pair Name	Berbamine, Sorafenib
Phytochemical	Berbamine
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Targeting Na+/K+-ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma

Pair Name	Berberine, Cisplatin
Phytochemical	Berberine
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Berberine and Cisplatin Exhibit Synergistic Anticancer Effects on Osteosarcoma MG-63 Cells by Inhibiting the MAPK Pathway

Pair Name	Bufalin, TNF-related apoptosis inducing ligand
Phytochemical	Bufalin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Expression
Result	Bufalin enhanced TRAIL-induced apoptosis by up-regulating the expression of DR4 and DR5. Bufalin-induced down-regulation of Cbl-b contributed to the up-regulation of DR4 and DR5, which might be partially mediated by the activation of ERK, JNK and p38 MAPK.

Pair Name	Chebulagic acid, Doxorubicin
Phytochemical	Chebulagic acid
Drug	Doxorubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Activity
Result	The present study shows the efficacy of CA to overcome MDR-1 mediated drug resistance in HepG2 cells through COX-2 dependant modulation of MDR-1.

Pair Name	Costunolide, Doxorubicin
Phytochemical	Costunolide
Drug	Doxorubicin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	We suggested that costunolide in combination with doxorubicin was a new potential chemotherapeutic strategy for treating prostate cancer.

Pair Name	Delta-Tocotrienol, Cisplatin
Phytochemical	Delta-Tocotrienol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	δ-Tocotrienol sensitizes and re-sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK-mediated apoptosis

Pair Name	Dihydroartemisinin, Oxaliplatin
Phytochemical	Dihydroartemisinin
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Expression
Result	We demonstrated an improved therapeutic strategy for CRC patients by combining DHA and oxaliplatin treatments.

Pair Name	Dihydroberberine, Sunitinib
Phytochemical	Dihydroberberine
Drug	Sunitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	DCS induced the expression of cell cycle signal molecules that are known to be affected by JNK and p38. The change of cell cycle, in turn, led to down-regulation of JNK and p38, and further reduced IL-1 secretion. Collectively, these findings highlight potential molecular mechanisms of DCS chemotherapeutic activity and suggest that DCS is an efficacious strategy in NSCLC therapy.

Pair Name	Licochalcone B, TNF-related apoptosis inducing ligand
Phytochemical	Licochalcone B
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	LCB exhibits cytotoxic activity through modulation of the Akt/mTOR, ER stress and MAPK pathways in HCC cells and effectively enhances TRAIL sensitivity through the upregulation of DR5 expression in ERK- and JNK-dependent manner. Combination therapy with LCB and TRAIL may be an alternative treatment strategy for HCC.

Pair Name	Matairesinol, Fluorouracil
Phytochemical	Matairesinol
Drug	Fluorouracil
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells

Pair Name	Morin Hydrate, Cisplatin
Phytochemical	Morin Hydrate
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Our findings indicate that CP-Mh in combination served as a prominent regulator of autophagy and significant inducer of apoptosis that maintains a homeostatic balance towards HepG2 cells and the subcutaneous tumor model.

Pair Name	Oleandrin, Cisplatin
Phytochemical	Oleandrin
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Activity
Result	The combination of oleandrin with cisplatin exerts a synergistic antitumor effect in osteosarcoma, which relates to the activation of the p38 MAPK pathway.

Pair Name	Oridonin, Fluorouracil
Phytochemical	Oridonin
Drug	Fluorouracil
Disease Info	[ICD-11: 2C90.Z]	Renal carcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Activity
Result	Oridonin enhances the cytotoxicity of 5-FU in renal cancer cells partially through inducing necroptosis, providing evidence of using necroptosis inducers in combination with chemotherapeutic agents for cancer treatment.

Pair Name	Piperlongumine, Oxaliplatin
Phytochemical	Piperlongumine
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Piperlongumine significantly enhanced oxaliplatin-induced growth inhibition of these cells and that TrxR1 activity is involved in their synergistic effect both in vitro and in vivo. These data suggest that PL and oxaliplatin combination treatment of gastric cancer may be more effective than oxaliplatin alone.

Pair Name	Resveratrol, Cisplatin
Phytochemical	Resveratrol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT

Pair Name	Resveratrol, Talazoparib
Phytochemical	Resveratrol
Drug	Talazoparib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Expression
Result	Resveratrol sensitizes breast cancer to PARP inhibitor, talazoparib through dual inhibition of AKT and autophagy flux

Pair Name	Resveratrol, Temozolomide
Phytochemical	Resveratrol
Drug	Temozolomide
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Activity
Result	TMZ in combination with resveratrol remarkably increased reactive oxygen species (ROS) production, which serves as an upstream signal for AMP-activated protein kinase (AMPK) activation. Subsequently, activated AMPK inhibited mTOR signaling and downregulated antiapoptosis protein Bcl-2, which was contributed to the additive antiproliferation effects of combination treatment. In an orthotopic xenograft model of GBM, TMZ plus resveratrol treatment significantly reduced the volume of tumor, which was confirmed by decreased expression of Ki-67, a marker of proliferation index

Pair Name	Silibinin, Sorafenib
Phytochemical	Silibinin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	These results suggested that silibinin improved the efficacy of sorafenib in HCC therapy, indicating a clinical promising therapeutic strategy for HCC patients.

Pair Name	Sulforaphene, Photodynamic therapy
Phytochemical	Sulforaphene
Drug	Photodynamic therapy
Disease Info	[ICD-11: 2D10.Z]	Thyroid cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Our work designates sulforaphene as a unique natural enhancer of efficacy with PDT against anaplastic thyroid cancer.

Pair Name	Thymoquinone, Temozolomide
Phytochemical	Thymoquinone
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Our findings demonstrate that TQ can effectively cross the BBB and function alone or in combination with TMZ to treat glioblastoma.

Pair Name	Vanillin, Fluorouracil
Phytochemical	Vanillin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Vanillin is deemed to be a promising anticancer candidate by inhibiting NNMT and may attenuate NNMT‑induced resistance to 5‑Fu in human CRC therapy with few side effects.

Pair Name	Vitamin C, Methotrexate
Phytochemical	Vitamin C
Drug	Methotrexate
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	Combined low-dose vitamin C and MTX had synergistic anti-proliferative/cytotoxic effects on TNBC cells. In addition, co-treatment increased H2O2 levels and activated both caspase-3 and p38 cell death pathways.

Pair Name	Xanthohumol, Praziquantel
Phytochemical	Xanthohumol
Drug	Praziquantel
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 14		Phosphorylation
Result	XN administered in combination with PZ could efficiently prevent CCA development and hence provide potential chemopreventive benefits in Ov-induced cholangiocarcinogenesis

Pair Name	Xanthorrhizol, Tamoxifen
Phytochemical	Xanthorrhizol
Drug	Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Expression
Result	It can be concluded that while there is no significant herb-drug interaction between xanthorrhizol and tamoxifen in vitro, there is such an interaction in tumor-bearing mice, which provides important information that affects breast cancer treatment translational research.

Pair Name	Gambogic acid, Cisplatin
Phytochemical	Gambogic acid
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Expression
Result	Our results demonstrate that GA may be a new potent therapeutic agent useful for targeting human OS cells.

Pair Name	Mitocurcumin, Cytarabine
Phytochemical	Mitocurcumin
Drug	Cytarabine
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 14		Activity
Result	The data suggest that MitoC exploits stress-induced leukemic oxidative environment to up-regulate JNK/p38 signaling to lead to apoptosis and can potentially overcome Cytarabine resistance via ROS/p21/CHK1 axis.