Pair Name	Paeonol, Epirubicin
Phytochemical Name	Paeonol
Anticancer drug Name	Epirubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Expression
Result	These findings suggest that combination of Paeonol and Epirubicin is potentially applicable for breast cancer treatment.

Pair Name	Withaferin A, Oxaliplatin
Phytochemical Name	Withaferin A
Anticancer drug Name	Oxaliplatin
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	These results support the notion that combination treatment with oxaliplatin and WA could facilitate development of an effective strategy for PC treatment.

Pair Name	(S)-10-Hydroxycamptothecin, Crizotinib
Phytochemical	(S)-10-Hydroxycamptothecin
Drug	Crizotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells

Pair Name	Acteoside, Temozolomide
Phytochemical	Acteoside
Drug	Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	It was also determined that TMZ + acteoside induced apoptosis and autophagy through the mitogen‑activated protein kinase signaling pathway. These findings suggest that acteoside has beneficial effects on TMZ‑based glioblastoma therapy.

Pair Name	Alantolactone, Oxaliplatin
Phytochemical	Alantolactone
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	These results suggest that the combination treatment with ALT and oxaliplatin may become a potential therapeutic strategy for colon cancer.

Pair Name	Alpha-Hederin, Carboplatin
Phytochemical	Alpha-Hederin
Drug	Carboplatin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling

Pair Name	Artesunate, Cisplatin
Phytochemical	Artesunate
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	ART exhibited significant anti-tumor effect on A549 cells and this efficiency could be enhanced by combination with CIS

Pair Name	Bakuchiol, TNF-related apoptosis inducing ligand
Phytochemical	Bakuchiol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	The collective results suggest that bakuchiol facilitates TRAIL-induced apoptosis in colon cancer cells through up-regulation of the TRAIL receptors; DR4 and DR5 via ROS/JNK pathway signals.

Pair Name	Berbamine, Cisplatin
Phytochemical	Berbamine
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	These findings indicate that Ber might be a promising adjuvant for enhancing the cancer cell killing effect of chemotherapy via the inhibition of autophagy. In this process, Nox2 might be a significant mediator of Ber-induced aberrant lysosomal acidification.

Pair Name	Berberine, Cisplatin
Phytochemical	Berberine
Drug	Cisplatin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Berberine and Cisplatin Exhibit Synergistic Anticancer Effects on Osteosarcoma MG-63 Cells by Inhibiting the MAPK Pathway

Pair Name	Bisdemethoxycucurmin, Icotinib
Phytochemical	Bisdemethoxycucurmin
Drug	Icotinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Our data indicate that BMDC has the potential to improve the treatment of primary EGFR-TKI resistant NISCLC that cannot be controlled with single-target agent, such as icotinib.

Pair Name	Bufalin, TNF-related apoptosis inducing ligand
Phytochemical	Bufalin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Expression
Result	Bufalin enhanced TRAIL-induced apoptosis by up-regulating the expression of DR4 and DR5. Bufalin-induced down-regulation of Cbl-b contributed to the up-regulation of DR4 and DR5, which might be partially mediated by the activation of ERK, JNK and p38 MAPK.

Pair Name	Chebulagic acid, Doxorubicin
Phytochemical	Chebulagic acid
Drug	Doxorubicin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Activity
Result	The present study shows the efficacy of CA to overcome MDR-1 mediated drug resistance in HepG2 cells through COX-2 dependant modulation of MDR-1.

Pair Name	Chicoric acid, TNF-related apoptosis inducing ligand
Phytochemical	Chicoric acid
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Activity
Result	Our results suggest that TO plays an important role in TRAIL-induced apoptosis, and further functional studies are warranted to confirm the importance of TO as a novel TRAIL sensitizer for cancer therapy.

Pair Name	Costunolide, Doxorubicin
Phytochemical	Costunolide
Drug	Doxorubicin
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	We suggested that costunolide in combination with doxorubicin was a new potential chemotherapeutic strategy for treating prostate cancer.

Pair Name	Daidzein, Gefitinib
Phytochemical	Daidzein
Drug	Gefitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Activity
Result	Daidzein Synergizes with Gefitinib to Induce ROS/JNK/c-Jun Activation and Inhibit EGFR-STAT/AKT/ERK Pathways to enhance Lung Adenocarcinoma cells chemosensitivity

Pair Name	Delta-Tocotrienol, Cisplatin
Phytochemical	Delta-Tocotrienol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	δ-Tocotrienol sensitizes and re-sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK-mediated apoptosis

Pair Name	Dihydroartemisinin, Oxaliplatin
Phytochemical	Dihydroartemisinin
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Expression
Result	We demonstrated an improved therapeutic strategy for CRC patients by combining DHA and oxaliplatin treatments.

Pair Name	Dihydroberberine, Sunitinib
Phytochemical	Dihydroberberine
Drug	Sunitinib
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	DCS induced the expression of cell cycle signal molecules that are known to be affected by JNK and p38. The change of cell cycle, in turn, led to down-regulation of JNK and p38, and further reduced IL-1 secretion. Collectively, these findings highlight potential molecular mechanisms of DCS chemotherapeutic activity and suggest that DCS is an efficacious strategy in NSCLC therapy.

Pair Name	Epsilon-Viniferin, alpha-Viniferin
Phytochemical	Epsilon-Viniferin
Drug	alpha-Viniferin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	ε-viniferin and α-viniferin may prove to be new approaches and effective therapeutic agents for osteosarcoma and lung cancer treatment.

Pair Name	Eriocalyxin B, Gemcitabine
Phytochemical	Eriocalyxin B
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10]	Pancreatic cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Gem and EriB (or Isodon extract) taken together in combination regulated PDK1/AKT1/caspase and JNK signaling and promoted apoptosis synergistically, which may contribute to the much increased anti-proliferative activity compared to either agent alone.

Pair Name	Gambogic Acid, Cisplatin
Phytochemical	Gambogic Acid
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Gambogic acid sensitises lung cancer cells to CDDP in vitro and in vivo in NSCLC through inactivation of NF-κB and MAPK/HO-1 signalling pathways, providing a rationale for the combined use of CDDP and GA in lung cancer chemotherapy.

Pair Name	Ginsenoside Rg3, Endostar
Phytochemical	Ginsenoside Rg3
Drug	Endostar
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Expression
Result	Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug, and it can inhibit angiogenesis and cell invasion, and enhance cell autophagy.

Pair Name	Glaucocalyxin B, Cisplatin
Phytochemical	Glaucocalyxin B
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	GLB enhances the sensitivity of ovarian cancer cells to cisplatin via increasing reactive oxygen species (ROS) levels, the phosphorylation of c-Jun N-terminal kinase (JNK), and DNA damage. A synergistic inhibitory effect of GLB with cisplatin was also observed in the cells which were resistance to cisplatin. These data suggest that GLB can sensitize ovarian cancer cells to cisplatin by increasing ROS levels.

Pair Name	Guggulsterone, Gemcitabine
Phytochemical	Guggulsterone
Drug	Gemcitabine
Disease Info	[ICD-11: 2C10.0]	Pancreatic ductal adenocarcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	The combination of guggulsterone to gemcitabine enhanced antitumor efficacy through apoptosis induction by suppressing Akt and nuclear factor KappaB activity and by modulating apoptosis-related protein expression in pancreatic cancer

Pair Name	Isodeoxyelephantopin, Cisplatin
Phytochemical	Isodeoxyelephantopin
Drug	Cisplatin
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Activity
Result	Our study provide a preclinical proof-of-concept for ESI as a potential strategy for colon cancer treatment.

Pair Name	Isoliquiritigenin, Docosahexaenoic acid
Phytochemical	Isoliquiritigenin
Drug	Docosahexaenoic acid
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Excessive ROS-induced JNK activation and cytochrome c release from mitochondria played a key role in the synergistic anticancer activity of CRC cells by cotreating with DHA and ISL.

Pair Name	Licochalcone A, Sorafenib
Phytochemical	Licochalcone A
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Expression
Result	These findings first revealed the synergistic effects of LicA and Sor cotreatment against human HCC cells, further suggesting that beneficial effects on tumor regression could be confirmed through prospective clinical trials.

Pair Name	Licochalcone B, TNF-related apoptosis inducing ligand
Phytochemical	Licochalcone B
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	LCB exhibits cytotoxic activity through modulation of the Akt/mTOR, ER stress and MAPK pathways in HCC cells and effectively enhances TRAIL sensitivity through the upregulation of DR5 expression in ERK- and JNK-dependent manner. Combination therapy with LCB and TRAIL may be an alternative treatment strategy for HCC.

Pair Name	Liquiritin, TNF-related apoptosis inducing ligand
Phytochemical	Liquiritin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Combining TRAIL and liquiritin exerts synergistic effects against human gastric cancer cells and xenograft in nude mice through potentiating apoptosis and ROS generation

Pair Name	Luteolin, Paclitaxel
Phytochemical	Luteolin
Drug	Paclitaxel
Disease Info	[ICD-11: 2B70]	Esophageal cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	The molecular mechanism of inhibiting cell migration and EMT processes may be related to the inhibition of SIRT1, and the mechanism of apoptosis induction is associated with the reactive oxygen species (ROS)/c-Jun N-terminal kinase (JNK) pathway-mediated activation of mitochondrial apoptotic pathway.

Pair Name	Luteolin, Sorafenib
Phytochemical	Luteolin
Drug	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Sorafenib and luteolin combination synergistically kills HCC cells through JNK-mediated apoptosis, and luteolin may be an ideal candidate for increasing the activity of sorafenib in HCC therapy.

Pair Name	Luteolin, TNF-related apoptosis inducing ligand
Phytochemical	Luteolin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	TRAIL combined with luteolin could be as an effective chemotherapeutic strategy for NSCLC.

Pair Name	Medicarpin, TNF-related apoptosis inducing ligand
Phytochemical	Medicarpin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B33.1]	Myeloid leukemia		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

Pair Name	Morin Hydrate, Cisplatin
Phytochemical	Morin Hydrate
Drug	Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Our findings indicate that CP-Mh in combination served as a prominent regulator of autophagy and significant inducer of apoptosis that maintains a homeostatic balance towards HepG2 cells and the subcutaneous tumor model.

Pair Name	Nimbolide, Tumor necrosis factor-alpha
Phytochemical	Nimbolide
Drug	Tumor necrosis factor-alpha
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Our findings overall indicate that nimbolide may enhance TNF-α-mediated cellular proliferation inhibition through increasing cell apoptosis of HT-29 cells by up-reglation of DR5 expression via the JNK pathway.

Pair Name	Oridonin, Cetuximab
Phytochemical	Oridonin
Drug	Cetuximab
Disease Info	[ICD-11: 2C23.Z]	Laryngeal cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Expression
Result	Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: Involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway

Pair Name	Oridonin, Fluorouracil
Phytochemical	Oridonin
Drug	Fluorouracil
Disease Info	[ICD-11: 2C90.Z]	Renal carcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Activity
Result	Oridonin enhances the cytotoxicity of 5-FU in renal cancer cells partially through inducing necroptosis, providing evidence of using necroptosis inducers in combination with chemotherapeutic agents for cancer treatment.

Pair Name	Piperlongumine, HSP90 inhibitors
Phytochemical	Piperlongumine
Drug	HSP90 inhibitors
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells

Pair Name	Piperlongumine, Oxaliplatin
Phytochemical	Piperlongumine
Drug	Oxaliplatin
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Piperlongumine significantly enhanced oxaliplatin-induced growth inhibition of these cells and that TrxR1 activity is involved in their synergistic effect both in vitro and in vivo. These data suggest that PL and oxaliplatin combination treatment of gastric cancer may be more effective than oxaliplatin alone.

Pair Name	Plumbagin, Cisplatin
Phytochemical	Plumbagin
Drug	Cisplatin
Disease Info	[ICD-11: 2B62.0]	Tongue squamous cell carcinoma		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Activity
Result	PLB combined with cisplatin is a potential therapeutic strategy against therapy TSCC cisplatin resistance.

Pair Name	Resveratrol, Cisplatin
Phytochemical	Resveratrol
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT

Pair Name	Resveratrol, Temozolomide
Phytochemical	Resveratrol
Drug	Temozolomide
Disease Info	[ICD-11: 2F7Z]	Glioma		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Activity
Result	TMZ in combination with resveratrol remarkably increased reactive oxygen species (ROS) production, which serves as an upstream signal for AMP-activated protein kinase (AMPK) activation. Subsequently, activated AMPK inhibited mTOR signaling and downregulated antiapoptosis protein Bcl-2, which was contributed to the additive antiproliferation effects of combination treatment. In an orthotopic xenograft model of GBM, TMZ plus resveratrol treatment significantly reduced the volume of tumor, which was confirmed by decreased expression of Ki-67, a marker of proliferation index

Pair Name	Sanguinarium, Cisplatin
Phytochemical	Sanguinarium
Drug	Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Our findings demonstrate that SNG induces mitochondrial and caspase-dependent apoptosis, generates oxidative stress, and suppresses MM cell lines proliferation. In addition, co-treatment of MM cell lines with sub-toxic doses of SNG and BTZ potentiated the cytotoxic activity. These results would suggest that SNG could be developed into therapeutic agent either alone or in combination with other anticancer drugs in MM.

Pair Name	Shikonin, BEZ235
Phytochemical	Shikonin
Drug	BEZ235
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	We found that low doses shikonin and dual PI3K-mTOR inhibitor (BEZ235) have a synergistic effect that inhibits the spheroid formation from chemoresistant lung cancer sublines. Inhibiting the proliferation of lung cancer stem cells is believed to reduce the recurrence of lung cancer; therefore, shikonin's anti-drug resistance and anti-cancer stem cell activities make it a highly interesting molecule for future combined lung cancer therapy.

Pair Name	Shikonin, TNF-related apoptosis inducing ligand
Phytochemical	Shikonin
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	The results indicated that shikonin sensitized resistant cancer cells to TRAIL-induced cytotoxicity via the modulation of the JNK, STAT3 and AKT pathways, the downregulation of antiapoptotic proteins and the upregulation of proapoptotic proteins.

Pair Name	Tangeretin, Fluorouracil
Phytochemical	Tangeretin
Drug	Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	To our knowledge gained from literature, this study is the first to describe synergistic activity of TAN and 5-FU against colorectal cancer cells.

Pair Name	Wogonin, Cisplatin
Phytochemical	Wogonin
Drug	Cisplatin
Disease Info	Head and neck cancer
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Wogonin induced selective cell death by targeting the antioxidant defense mechanisms enhanced in the resistant HNC cells and activating cell death pathways involving PUMA and PARP. Hence, wogonin significantly sensitized resistant HNC cells to cisplatin both in vitro and in vivo. Wogonin is a promising anticancer candidate that induces ROS accumulation and selective cytotoxicity in HNC cells and can help to overcome cisplatin-resistance in this cancer.

Pair Name	Cepharanthine, Cisplatin
Phytochemical	Cepharanthine
Drug	Cisplatin
Disease Info	[ICD-11: 2B70]	Esophageal cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals

Pair Name	Honokiol, Paclitaxel
Phytochemical	Honokiol
Drug	Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	Synergistic killing effect of paclitaxel and honokiol in non-small cell lung cancer cells through paraptosis induction

Pair Name	Mitocurcumin, Cytarabine
Phytochemical	Mitocurcumin
Drug	Cytarabine
Disease Info	[ICD-11: 2B33.4]	Leukemia		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	The data suggest that MitoC exploits stress-induced leukemic oxidative environment to up-regulate JNK/p38 signaling to lead to apoptosis and can potentially overcome Cytarabine resistance via ROS/p21/CHK1 axis.

Pair Name	Sclareol, Cisplatin
Phytochemical	Sclareol
Drug	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Regulate Info	Down-regulation	Mitogen-activated protein kinase 8		Expression
Result	Sclareol has potential as an adjuvant for the treatment in NSCLC patients with cisplatin resistance.

Pair Name	Shogaol, TNF-related apoptosis inducing ligand
Phytochemical	Shogaol
Drug	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B90]	Colon cancer		Investigative
Regulate Info	Up-regulation	Mitogen-activated protein kinase 8		Phosphorylation
Result	This study gives rise to the possibility of applying shogaol as an antitumor agent that can be used for the purpose of combination treatment with TRAIL in TRAIL-resistant colon tumor therapy.