| Name | Cyclin-dependent kinase inhibitor 1B | ||
| UniProt ID | CDN1B_HUMAN | ||
| Gene Name | CDKN1B | ||
| Gene ID | 1027 | ||
| Synonyms |
CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1
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| Sequence |
MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKW
NFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAAPLIG APANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPN AGSVEQTPKKPGLRRRQT |
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| Pathway Map | MAP LINK | ||
| KEGG ID | hsa1027 | ||
| TTD ID | T14006 | ||
| Pfam | PF02234; PF13447 | ||
| Pair Name | Gossypol, Zoledronic acid | |||
| Phytochemical | Gossypol | |||
| Drug | Zoledronic acid | |||
| Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
| Regulate Info | Up-regulation | Cyclin-dependent kinase inhibitor 1B | Expression | |
| Result | GP significantly enhances the anti-tumor activity of ZA in hormone- and drug-resistant prostate cancer cells by targeting many pivotal apoptosis-related proteins. | |||
| Pair Name | Resveratrol, Cisplatin | |||
| Phytochemical | Resveratrol | |||
| Drug | Cisplatin | |||
| Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
| Regulate Info | Up-regulation | Cyclin-dependent kinase inhibitor 1B | Activity | |
| Result | These results indicated that RES is a promising adjuvant for DDP during GC chemotherapy. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Targeting apoptosis in the hormone- and drug-resistant prostate cancer cell line, DU-145, by gossypol/zoledronic acid combination. Cell Biol Int. 2009 Nov;33(11):1165-72. doi: 10.1016/j.cellbi.2009.08.006. | Click |
| 2 | Resveratrol synergizes with cisplatin in antineoplastic effects against AGS gastric cancer cells by inducing endoplasmic reticulum stress‑mediated apoptosis and G2/M phase arrest. Oncol Rep. 2020 Oct;44(4):1605-1615. doi: 10.3892/or.2020.7708. | Click |
