InterPAD - DETAILS

4',5',7-trihydroxy-6-methoxyisoflavone, tectorigenin

No.	Title	Href
1	Tectorigenin sensitizes paclitaxel-resistant human ovarian cancer cells through downregulation of the Akt and NFκB pathway. Carcinogenesis. 2012 Dec;33(12):2488-98. doi: 10.1093/carcin/bgs302.	`Click`

No.

Title

Href

Tectorigenin sensitizes paclitaxel-resistant human ovarian cancer cells through downregulation of the Akt and NFκB pathway. Carcinogenesis. 2012 Dec;33(12):2488-98. doi: 10.1093/carcin/bgs302.

Click

Name	Tectorigenin
PubChem CID	5281811
Molecular Weight	300.26g/mol
Synonyms	4',5',7-trihydroxy-6-methoxyisoflavone, tectorigenin
Formula	C₁₆H₁₂O₆
SMILES	COC1=C(C2=C(C=C1O)OC=C(C2=O)C3=CC=C(C=C3)O)O
InChI	1S/C16H12O6/c1-21-16-11(18)6-12-13(15(16)20)14(19)10(7-22-12)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3
InChIKey	OBBCRPUNCUPUOS-UHFFFAOYSA-N
CAS Number	548-77-6
ChEMBL ID	CHEMBL242740
ChEBI ID	CHEBI:9429
Herb ID	HBIN045833
KEGG ID	C10534
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	FenGe
Use Part	Root
Habitat	GuangDong, GuangXi, SiChuan, GuiZhou, YunNan
Flavor	Sweet, Pungent
Meridian Tropism	Spleen, Stomach

Chineses Pinyin	DangShen
Use Part	Root
Habitat	HuBei, HuNan, SiChuan, GuiZhou
Flavor	Sweet
Meridian Tropism	Spleen, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asterales 　　　　-->Family: Campanulaceae 　　　　　-->Genus: Codonopsis 　　　　　　-->Species: Codonopsis pilosula

Chineses Pinyin	SangBaiPi
Use Part	Root Bark
Habitat	China
Flavor	Sweet
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Rosales 　　　　-->Family: Moraceae 　　　　　-->Genus: Morus 　　　　　　-->Species: Morus alba

Chineses Pinyin	ChuanSheGan
Use Part	Rhizome
Habitat	Shaanxi, JiangSu, ZheJiang, JiangXi, HuBei, HuNan, GuangDong, GuangXi
Flavor	Bitter
Meridian Tropism	Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Iridaceae 　　　　　-->Genus: Iris 　　　　　　-->Species: Iris tectorum

Chineses Pinyin	SheGan
Use Part	Rhizome
Habitat	HuBei, JiangSu, HeNan, AnHui
Flavor	Bitter
Meridian Tropism	Lung

Chineses Pinyin	BaiHuaSheGan
Use Part	Whole Herb
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, NingXia, GanSu, QingHai, ShanDong, AnHui, JiangSu, JiangXi, HeNan
Flavor	Bitter, Pungent
Meridian Tropism	Lung, Stomach, Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Iridaceae 　　　　　-->Genus: Iris 　　　　　　-->Species: Iris dichotoma

Chineses Pinyin	DeGuoYuanWei
Use Part	Stem-Leaf
Habitat	GuangDong, GuangXi, SiChuan, GuiZhou
Flavor	Bitter, Pungent
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Iridaceae 　　　　　-->Genus: Iris 　　　　　　-->Species: Iris tectorum

Chineses Pinyin	YuanWei
Use Part	Leaf, Whole Herb
Habitat	Japan
Flavor	Bitter, Pungent
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Iridaceae 　　　　　-->Genus: Iris 　　　　　　-->Species: Iris tectorum

Chineses Pinyin	YeGe
Use Part	Root
Flavor	Pungent; Sweet
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Pueraria 　　　　　　-->Species: Pueraria montana

Pair Name	Tectorigenin, Paclitaxel
Partner Name	Paclitaxel
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Gene Regulation	Down-regulation	Activity	AKT1	hsa207
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Up-regulation	Activity	CASP3	hsa836
	Up-regulation	Activity	CASP8	hsa841
	Up-regulation	Activity	CASP9	hsa842
	Down-regulation	Expression	CFLAR	hsa8837
	Down-regulation	Phosphorylation	CHUK	hsa1147
	Down-regulation	Phosphorylation	CHUK	hsa1147
	Down-regulation	Expression	COX2	hsa4513
	Down-regulation	Phosphorylation	IKBKE	hsa9641
	Down-regulation	Activity	NFKB1	hsa4790
	Down-regulation	Phosphorylation	NFKBIA	hsa4792
	Down-regulation	Expression	XIAP	hsa331
In Vitro Model	MPSC1	Low grade ovarian serous adenocarcinoma	Homo sapiens (Human)	CVCL_9822
	A2780	Ovarian endometrioid adenocarcinoma	Homo sapiens (Human)	CVCL_0134
	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens (Human)	CVCL_0532
Result	These data suggest that tectorigenin could sensitize paclitaxel-resistant human ovarian cancer cells through inactivation of the Akt/IKK/IκB/NFκB signaling pathway, and promise a new intervention to chemosensitize paclitaxel-induced cytotoxicity in ovarian cancer.