gedunin
| Name | Gedunin | ||
| PubChem CID | 12004512 | ||
| Molecular Weight | 482.6g/mol | ||
| Synonyms |
gedunin |
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| Formula | C₂₈H₃₄O₇ | ||
| SMILES | CC(=O)OC1CC2C(C(=O)C=CC2(C3C1(C45C(O4)C(=O)OC(C5(CC3)C)C6=COC=C6)C)C)(C)C | ||
| InChI | 1S/C28H34O7/c1-15(29)33-20-13-18-24(2,3)19(30)8-10-25(18,4)17-7-11-26(5)21(16-9-12-32-14-16)34-23(31)22-28(26,35-22)27(17,20)6/h8-10,12,14,17-18,20-22H,7,11,13H2,1-6H3/t17-,18+,20-,21+,22-,25-,26+,27+,28-/m1/s1 | ||
| InChIKey | YJXDGWUNRYLINJ-BHAPSIHVSA-N | ||
| CAS Number | 2753-30-2 | ||
| ChEMBL ID | CHEMBL465226 | ||
| ChEBI ID | CHEBI:65954 | ||
| Herb ID | HBIN027407 | ||
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | KuLianPi | ||
| Use Part | Bark | ||
| Habitat | SiChuan, GuiZhou, HuNan, HuBei, HeNan, GanSu | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver, Spleen, Stomach | ||
| Chineses Pinyin | KuLianShi | ||
| Use Part | Fruit | ||
| Habitat | ShanXi, HeBei, BeiJing, TianJin, ShanDong | ||
| Flavor | Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Meliaceae
-->Genus: Melia
-->Species: Melia azedarach
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| Chineses Pinyin | ShanZhuZi | ||
| Use Part | Bark, Fruit | ||
| Habitat | JiangXi, FuJian, TaiWan, GuangDong, GuangXi, YunNan | ||
| Flavor | Bitter, Astringent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Malpighiales
-->Family: Clusiaceae
-->Genus: Garcinia
-->Species: Garcinia multiflora
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| Chineses Pinyin | KuLanPi | ||
| Use Part | Dried bark and root bark | ||
| Habitat | SiChuan, GuiZhou, HuNan, HuBei, HeNan, GanSu | ||
| Flavor | Bitter | ||
| Meridian Tropism | Liver; Spleen; Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Sapindales
-->Family: Meliaceae
-->Genus: Melia
-->Species: Melia azedarach
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| Pair Name | Gedunin, Epalrestat | |||
| Partner Name | Epalrestat | |||
| Disease Info | [ICD-11: 2B66.Z] | Oral cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in the G1/S phase | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Down-regulation | Expression | AR | hsa367 | |
| Down-regulation | Expression | CHUK | hsa1147 | |
| Down-regulation | Expression | MAPK1 | hsa5594 | |
| Down-regulation | Expression | NFKB1 | hsa4790 | |
| Down-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | SCC-131 | Rat squamous cell carcinoma | Rattus norvegicus (Rat) | CVCL_6726 |
| Result | Our results provide compelling evidence that the combination of gedunin and epalrestat modulates expression of key oncogenic signalling kinases and transcription factors primarily by influencing phosphorylation and subcellular localisation. AR inhibitors such as gedunin and epalrestat are novel candidate agents for cancer prevention and therapy. | |||
