tectochrysin
| Name | Tectochrysin | ||
| PubChem CID | 5281954 | ||
| Molecular Weight | 268.26g/mol | ||
| Synonyms |
tectochrysin |
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| Formula | C₁₆H₁₂O₄ | ||
| SMILES | COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O | ||
| InChI | 1S/C16H12O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-9,17H,1H3 | ||
| InChIKey | IRZVHDLBAYNPCT-UHFFFAOYSA-N | ||
| CAS Number | 520-28-5 | ||
| ChEMBL ID | CHEMBL164841 | ||
| ChEBI ID | CHEBI:9426 | ||
| Herb ID | HBIN045831 | ||
| KEGG ID | C11621 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | YiZhi | ||
| Use Part | Fruit | ||
| Habitat | HaiNan, GuangDong | ||
| Flavor | Pungent | ||
| Meridian Tropism | Kidney; Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Alpinia
-->Species: Alpinia oxyphylla
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| Pair Name | Tectochrysin, Cetuximab | |||
| Partner Name | Cetuximab | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Down-regulation | Expression | CD40 | hsa958 | |
| Down-regulation | Expression | CXCL8 | hsa3576 | |
| Down-regulation | Phosphorylation | EGFR | hsa1956 | |
| Down-regulation | Expression | FOS | hsa2353 | |
| Down-regulation | Phosphorylation | IKBKE | hsa9641 | |
| Down-regulation | Activity | JUN | hsa3725 | |
| Down-regulation | Activity | NFKB1 | hsa4790 | |
| Down-regulation | Expression | PTGS2 | hsa5743 | |
| Down-regulation | Expression | RELA | hsa5970 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| SW480 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0546 | |
| Result | Our results indicate that combined therapy with lower concentration of cetuximab and tectochrysin could significantly enhance the cancer cell growth inhibitory effect through the inhibition of EGFR signaling. | |||
