4',5-diallyl-2,3-dihydroxybiphenyl ether, obovatol
| Name | Obovatol | ||
| PubChem CID | 100771 | ||
| Molecular Weight | 282.3g/mol | ||
| Synonyms |
4',5-diallyl-2,3-dihydroxybiphenyl ether, obovatol |
||
| Formula | C₁₈H₁₈O₃ | ||
| SMILES | C=CCC1=CC=C(C=C1)OC2=CC(=CC(=C2O)O)CC=C | ||
| InChI | 1S/C18H18O3/c1-3-5-13-7-9-15(10-8-13)21-17-12-14(6-4-2)11-16(19)18(17)20/h3-4,7-12,19-20H,1-2,5-6H2 | ||
| InChIKey | OPGPFZQBCIAFLI-UHFFFAOYSA-N | ||
| CAS Number | 83864-78-2 | ||
| ChEMBL ID | CHEMBL491809 | ||
| Herb ID | HBIN037658 | ||
| Structure | 
|
Download
2D
MOL
3D
MOL
|
|
| Chineses Pinyin | HouPu | ||
| Use Part | Bark | ||
| Habitat | SiChuan, HuBei | ||
| Flavor | Bitter, Pungent | ||
| Meridian Tropism | Spleen, Stomach, Lung, Large intestine | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Magnoliales
-->Family: Magnoliaceae
-->Genus: Magnolia
-->Species: Magnolia officinalis
|
||
| Pair Name | Obovatol, Docetaxel | |||
| Partner Name | Docetaxel | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | NFKB1 | hsa4790 |
| In Vitro Model | LNCaP | Prostate carcinoma | Homo sapiens (Human) | CVCL_0395 |
| PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 | |
| SW620 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0547 | |
| HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 | |
| Result | These results indicate that obovatol augments cell growth inhibition by chemotherapeutics through inactivation of NF-kappaB and suggest that obovatol may have therapeutic advantages in the combination treatment with other chemotherapeutics. | |||
