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Phytochemical Details

01. General Information

Name	Neferine
PubChem CID	159654
Molecular Weight	624.8g/mol
Synonyms	neferine
Formula	C₃₈H₄₄N₂O₆
SMILES	CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC
InChI	1S/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32-/m1/s1
InChIKey	MIBATSHDJRIUJK-ROJLCIKYSA-N
CAS Number	2292-16-2
ChEMBL ID	CHEMBL455560
ChEBI ID	CHEBI:176257
Herb ID	HBIN036518
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

02. Source Information of Phytochemical

(1) Nelumbo nucifera Even

Chineses Pinyin	LianZi
Use Part	Seed
Habitat	HuNan, HuBei, FuJian, JiangSu, ZheJiang
Flavor	Sweet, Astringent
Meridian Tropism	Spleen, Kidney, Heart
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Proteales 　　　　-->Family: Nelumbonaceae 　　　　　-->Genus: Nelumbo 　　　　　　-->Species: Nelumbo nucifera

(2) Nelumbo nucifera Cold

Chineses Pinyin	LianZiXin
Use Part	Dried Plumule And Radicle In Seed
Habitat	HuNan, HuBei, FuJian, JiangSu, ZheJiang
Flavor	Bitter
Meridian Tropism	Heart, Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Proteales 　　　　-->Family: Nelumbonaceae 　　　　　-->Genus: Nelumbo 　　　　　　-->Species: Nelumbo nucifera

(3) Nelumbo nucifera Even

Chineses Pinyin	OuJie
Use Part	Rhizome Node
Habitat	ZheJiang, JiangSu, AnHui
Flavor	Sweet, Astringent
Meridian Tropism	Liver, Lung, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Proteales 　　　　-->Family: Nelumbonaceae 　　　　　-->Genus: Nelumbo 　　　　　　-->Species: Nelumbo nucifera

(4) Nelumbo nucifera Cold

Chineses Pinyin	Ou
Use Part	Rhizome
Habitat	China
Flavor	Sweet
Meridian Tropism	Heart, Spleen, Stomach, Liver, Lung
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Proteales 　　　　-->Family: Nelumbonaceae 　　　　　-->Genus: Nelumbo 　　　　　　-->Species: Nelumbo nucifera

(5) Nelumbo nucifera Cold

Chineses Pinyin	LianXin
Use Part	Seed
Habitat	HuNan, HuBei, FuJian, JiangSu, ZheJiang
Flavor	Sweet; Punkery
Meridian Tropism	Spleen; Heart; Kidney
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Proteales 　　　　-->Family: Nymphaeaceae 　　　　　-->Genus: Nelumbo 　　　　　　-->Species: Nelumbo nucifera

03. Combinatorial Therapeutic Effect(s)

Synergistic Effect

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Drug(s) whose efficacy can be enhanced by this phytochemical

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Combination Pair ID: 457

Ref_1

Pair Name	Neferine, Vitamin D3
Partner Name	Vitamin D3
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Biological Phenomena	Inhibition-->Cell metastasis
Gene Regulation	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	VIM	hsa7431
	Down-regulation	Expression	SNAI1	hsa6615
	Down-regulation	Expression	SNAI2	hsa6591
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
Result	These data suggest that neferine enhances the anticancer capability of VD3 and reduces the dose dependency of VD3. The combination of vitamin D with neferine appears to be a potential therapeutic strategy for CRC.

Combination Pair ID: 458

Ref_2

Pair Name	Neferine, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C90.Z]	Renal carcinoma		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
Gene Regulation	Down-regulation	Activity	NFKB1	hsa4790
In Vitro Model	Caki-1	Clear cell renal cell carcinoma	Homo sapiens (Human)	CVCL_0234
Result	Neferine increases sensitivities to multiple anticancer drugs via downregulation of Bcl-2 expression in renal cancer cells

04. Reference

No.	Title	Href
1	Combined effects of vitamin D and neferine on the progression and metastasis of colorectal cancer. J Cancer Res Clin Oncol. 2023 Aug;149(9):6203-6210. doi: 10.1007/s00432-022-04552-7.	`Click`
2	Neferine increases sensitivities to multiple anticancer drugs via downregulation of Bcl-2 expression in renal cancer cells. Genes Genomics. 2022 Feb;44(2):165-173. doi: 10.1007/s13258-021-01201-0.	`Click`