neferine
| Name | Neferine | ||
| PubChem CID | 159654 | ||
| Molecular Weight | 624.8g/mol | ||
| Synonyms |
neferine |
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| Formula | C₃₈H₄₄N₂O₆ | ||
| SMILES | CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC | ||
| InChI | 1S/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32-/m1/s1 | ||
| InChIKey | MIBATSHDJRIUJK-ROJLCIKYSA-N | ||
| CAS Number | 2292-16-2 | ||
| ChEMBL ID | CHEMBL455560 | ||
| ChEBI ID | CHEBI:176257 | ||
| Herb ID | HBIN036518 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | LianZi | ||
| Use Part | Seed | ||
| Habitat | HuNan, HuBei, FuJian, JiangSu, ZheJiang | ||
| Flavor | Sweet, Astringent | ||
| Meridian Tropism | Spleen, Kidney, Heart | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Proteales
-->Family: Nelumbonaceae
-->Genus: Nelumbo
-->Species: Nelumbo nucifera
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| Chineses Pinyin | LianZiXin | ||
| Use Part | Dried Plumule And Radicle In Seed | ||
| Habitat | HuNan, HuBei, FuJian, JiangSu, ZheJiang | ||
| Flavor | Bitter | ||
| Meridian Tropism | Heart, Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Proteales
-->Family: Nelumbonaceae
-->Genus: Nelumbo
-->Species: Nelumbo nucifera
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| Chineses Pinyin | OuJie | ||
| Use Part | Rhizome Node | ||
| Habitat | ZheJiang, JiangSu, AnHui | ||
| Flavor | Sweet, Astringent | ||
| Meridian Tropism | Liver, Lung, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Proteales
-->Family: Nelumbonaceae
-->Genus: Nelumbo
-->Species: Nelumbo nucifera
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| Chineses Pinyin | Ou | ||
| Use Part | Rhizome | ||
| Habitat | China | ||
| Flavor | Sweet | ||
| Meridian Tropism | Heart, Spleen, Stomach, Liver, Lung | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Proteales
-->Family: Nelumbonaceae
-->Genus: Nelumbo
-->Species: Nelumbo nucifera
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| Chineses Pinyin | LianXin | ||
| Use Part | Seed | ||
| Habitat | HuNan, HuBei, FuJian, JiangSu, ZheJiang | ||
| Flavor | Sweet; Punkery | ||
| Meridian Tropism | Spleen; Heart; Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Proteales
-->Family: Nymphaeaceae
-->Genus: Nelumbo
-->Species: Nelumbo nucifera
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| Pair Name | Neferine, Vitamin D3 | |||
| Partner Name | Vitamin D3 | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| Gene Regulation | Up-regulation | Expression | CDH1 | hsa999 |
| Down-regulation | Expression | CDH2 | hsa1000 | |
| Down-regulation | Expression | SNAI1 | hsa6615 | |
| Down-regulation | Expression | SNAI2 | hsa6591 | |
| Down-regulation | Expression | VIM | hsa7431 | |
| In Vitro Model | HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 |
| Result | These data suggest that neferine enhances the anticancer capability of VD3 and reduces the dose dependency of VD3. The combination of vitamin D with neferine appears to be a potential therapeutic strategy for CRC. | |||
| Pair Name | Neferine, Cisplatin | |||
| Partner Name | Cisplatin | |||
| Disease Info | [ICD-11: 2C90.Z] | Renal carcinoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Down-regulation | Activity | NFKB1 | hsa4790 | |
| In Vitro Model | Caki-1 | Clear cell renal cell carcinoma | Homo sapiens (Human) | CVCL_0234 |
| Result | Neferine increases sensitivities to multiple anticancer drugs via downregulation of Bcl-2 expression in renal cancer cells | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combined effects of vitamin D and neferine on the progression and metastasis of colorectal cancer. J Cancer Res Clin Oncol. 2023 Aug;149(9):6203-6210. doi: 10.1007/s00432-022-04552-7. | Click |
| 2 | Neferine increases sensitivities to multiple anticancer drugs via downregulation of Bcl-2 expression in renal cancer cells. Genes Genomics. 2022 Feb;44(2):165-173. doi: 10.1007/s13258-021-01201-0. | Click |
