costunolide, isocostunolide
| Name | Costunolide | ||
| PubChem CID | 5281437 | ||
| Molecular Weight | 232.32g/mol | ||
| Synonyms |
costunolide, isocostunolide |
||
| Formula | C₁₅H₂₀O₂ | ||
| SMILES | CC1=CCCC(=CC2C(CC1)C(=C)C(=O)O2)C | ||
| InChI | 1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1 | ||
| InChIKey | HRYLQFBHBWLLLL-AHNJNIBGSA-N | ||
| CAS Number | 553-21-9 | ||
| ChEMBL ID | CHEMBL86416 | ||
| ChEBI ID | CHEBI:3900 | ||
| Herb ID | HBIN021599 | ||
| KEGG ID | C09382 | ||
| Structure | 
|
Download
2D
MOL
3D
MOL
|
|
| Chineses Pinyin | ChuanMuXiang | ||
| Use Part | Root | ||
| Habitat | SiChuan, XiZang | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Spleen, Stomach, Large intestine, Gallbladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Dolomiaea
-->Species: Dolomiaea souliei
|
||
| Chineses Pinyin | MuXiang | ||
| Use Part | Root | ||
| Habitat | YunNan, SiChuan | ||
| Flavor | Pungent, Bitter | ||
| Meridian Tropism | Spleen, Stomach, Large intestine, Triple burner, Gallbladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Aucklandia
-->Species: Aucklandia lappa
|
||
| Chineses Pinyin | MuBieGen | ||
| Use Part | Tuberoid | ||
| Habitat | JiangSu, AnHui, JiangXi, FuJian, TaiWan, GuangDong, GuangXi, HuNan, SiChuan, GuiZhou | ||
| Flavor | Bitter, Mildly sweet | ||
| Chineses Pinyin | YueGuiYe | ||
| Use Part | Leaf | ||
| Habitat | JiangSu, ZheJiang, FuJian, TaiWan, SiChuan, YunNan | ||
| Flavor | Pungent | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Laurales
-->Family: Lauraceae
-->Genus: Laurus
-->Species: Laurus nobilis
|
||
| Chineses Pinyin | YunMuXiang | ||
| Use Part | Root | ||
| Flavor | Pungent; Bitter | ||
| Meridian Tropism | Spleen; Stomach; Large intestine; Gallbladder; Triple Energizers | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Magnoliopsida
-->Order: Asterales
-->Family: Asteraceae
-->Genus: Saussurea
-->Species: Saussurea costus
|
||
| Pair Name | Costunolide, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
| Biological Phenomena | Induction-->ROS generation | |||
| Gene Regulation | Up-regulation | Phosphorylation | MAPK14 | hsa1432 |
| Up-regulation | Phosphorylation | MAPK8 | hsa5599 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | DU145 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0105 |
| PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 | |
| In Vivo Model | PC-3 cells (3×10⁶) were injected subcutaneously into the armpit of each mouse. | |||
| Result | We suggested that costunolide in combination with doxorubicin was a new potential chemotherapeutic strategy for treating prostate cancer. | |||
| Pair Name | Costunolide, Imatinib | |||
| Partner Name | Imatinib | |||
| Disease Info | [ICD-11: 2B33.3] | Acute lymphoblastic leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| In Vitro Model | K-562 | Blast phase chronic myelogenous leukemia | Homo sapiens (Human) | CVCL_0004 |
| Result | These results demonstrate that costunolide may be a potent therapeutic agent against chronic myeloid leukemia. | |||
| Pair Name | Costunolide, Doxorubicin | |||
| Partner Name | Doxorubicin | |||
| Disease Info | [ICD-11: 2B33.3] | Acute lymphoblastic leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Phosphorylation | PIK3CA | hsa5290 | |
| In Vitro Model | K-562 | Blast phase chronic myelogenous leukemia | Homo sapiens (Human) | CVCL_0004 |
| Result | These results demonstrate that costunolide may be a potent therapeutic agent against chronic myeloid leukemia. | |||
| Pair Name | Costunolide, Osimertinib | |||
| Partner Name | Osimertinib | |||
| Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Phosphorylation | GSK3B | hsa2932 | |
| Down-regulation | Phosphorylation | MAP2K1 | KEGG ID N.A. | |
| Down-regulation | Phosphorylation | MAPK1 | hsa5594 | |
| Down-regulation | Phosphorylation | NFKB1 | hsa4790 | |
| Down-regulation | Phosphorylation | RPS6KA3 | KEGG ID N.A. | |
| In Vitro Model | PC-9 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_B260 |
| HCC827 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_2063 | |
| NCI-H1975 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_1511 | |
| In Vivo Model | 6–7 weeks old female mice with severe combined immunodeficiency (SCID) were employed to eatablish osimertinib-resistant PDX model. | |||
| Result | The combination of osimertinib and costunolide showed synergistic or additive inhibitory effects on tumor growth in osimertinib-resistant cell lines and PDX model. Hence, this study highlights a potential therapeutic strategy for osimertinib-resistant patients through targeting of MEK1 and AKT1/2 by costunolide. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Costunolide enhances doxorubicin-induced apoptosis in prostate cancer cells via activated mitogen-activated protein kinases and generation of reactive oxygen species. Oncotarget. 2017 Nov 21;8(64):107701-107715. doi: 10.18632/oncotarget.22592. | Click |
| 2 | Costunolide promotes imatinib-induced apoptosis in chronic myeloid leukemia cells via the Bcr/Abl-Stat5 pathway. Phytother Res. 2018 Sep;32(9):1764-1769. doi: 10.1002/ptr.6106. | Click |
| 3 | Costunolide enhances sensitivity of K562/ADR chronic myeloid leukemia cells to doxorubicin through PI3K/Akt pathway. Phytother Res. 2019 Jun;33(6):1683-1688. doi: 10.1002/ptr.6355. | Click |
| 4 | Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer. Mol Cancer. 2022;21(1):193. Published 2022 Oct 6. doi:10.1186/s12943-022-01662-1 | Click |
