| Name | Beta-Sitosterol | ||
| PubChem CID | 222284 | ||
| Molecular Weight | 414.7g/mol | ||
| Synonyms |
24-ethylcholest-5-en-3 beta-ol, 24-ethylcholesterol, 3beta-sitosterol, 3beta-stigmast-5-en-3-ol, beta-sitosterol, clionasterol, gamma-sitosterol, Harzol, sitosterol, sitosterol, (3beta)-isomer, sitosterol, (3beta,24xi)-isomer, sitosterol, 26-(14)C-labeled, stigmast-5-en-3-ol, (3beta,24S)- |
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| Formula | C₂₉H₅₀O | ||
| SMILES | CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C | ||
| InChI | 1S/C29H50O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h10,19-21,23-27,30H,7-9,11-18H2,1-6H3/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1 | ||
| InChIKey | KZJWDPNRJALLNS-VJSFXXLFSA-N | ||
| CAS Number | 83-46-5 | ||
| ChEMBL ID | CHEMBL221542 | ||
| ChEBI ID | CHEBI:27693 | ||
| Drug Bank ID | DB14038 | ||
| KEGG ID | C01753 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| rat | LD50 | intraperitoneal(165 mg/kg) | |
| mouse | LD50 | intraperitoneal(254 mg/kg) | |
| rat | LD50 | oral(322 mg/kg) | |
| Structure | 
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Download
2D
MOL
3D
MOL
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| Chineses Pinyin | DaDou | ||
| Habitat | China | ||
| Flavor | Pungent; Bitter | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Fabales
-->Family: Fabaceae
-->Genus: Glycin
-->Species: Glycine max
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| Pair Name | Beta-Sitosterol, Gemcitabine | |||
| Partner Name | Gemcitabine | |||
| Disease Info | [ICD-11: 2C10] | Pancreatic cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G0/G1 phase | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CDH1 | hsa999 | |
| Down-regulation | Phosphorylation | GSK3B | hsa2932 | |
| Down-regulation | Phosphorylation | NFKB1 | hsa4790 | |
| Down-regulation | Expression | SNAI1 | hsa6615 | |
| Down-regulation | Expression | VIM | hsa7431 | |
| In Vitro Model | MIA PaCa-2 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0428 |
| BxPC-3 | Pancreatic ductal adenocarcinoma | Homo sapiens (Human) | CVCL_0186 | |
| In Vivo Model | BXPC-3 cells (0.2 mL; 7×10⁶ cells) were subcutaneously injected into the right flank of the nude mice. | |||
| Result | β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling | |||
| No. | Title | Href |
|---|---|---|
| 1 | β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-Pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling. Front Pharmacol. 2020 Nov 20;11:565535. doi: 10.3389/fphar.2020.565535. | Click |
