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2',4',4-trihydroxychalcone, 6'-deoxychalcone, GU 17, GU-17, isoliquiritigenin

No.	Title	Href
1	Isoliquiritigen enhances the antitumour activity and decreases the genotoxic effect of cyclophosphamide. Molecules. 2013 Jul 24;18(8):8786-98. doi: 10.3390/molecules18088786.	`Click`
2	Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma. J Pharmacol Sci. 2008 Mar;106(3):444-51. doi: 10.1254/jphs.fp0071498.	`Click`
3	Synergistic anticancer effect of docosahexaenoic acid and isoliquiritigenin on human colorectal cancer cells through ROS-mediated regulation of the JNK and cytochrome c release. Mol Biol Rep. 2021 Feb;48(2):1171-1180. doi: 10.1007/s11033-021-06159-6.	`Click`
4	Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. Environ Health Prev Med. 2008 Sep;13(5):281-7. doi: 10.1007/s12199-008-0041-1.	`Click`

No.

Title

Href

Isoliquiritigen enhances the antitumour activity and decreases the genotoxic effect of cyclophosphamide. Molecules. 2013 Jul 24;18(8):8786-98. doi: 10.3390/molecules18088786.

Click

Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma. J Pharmacol Sci. 2008 Mar;106(3):444-51. doi: 10.1254/jphs.fp0071498.

Click

Synergistic anticancer effect of docosahexaenoic acid and isoliquiritigenin on human colorectal cancer cells through ROS-mediated regulation of the JNK and cytochrome c release. Mol Biol Rep. 2021 Feb;48(2):1171-1180. doi: 10.1007/s11033-021-06159-6.

Click

Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. Environ Health Prev Med. 2008 Sep;13(5):281-7. doi: 10.1007/s12199-008-0041-1.

Click

Name	Isoliquiritigenin
PubChem CID	638278
Molecular Weight	256.25g/mol
Synonyms	2',4',4-trihydroxychalcone, 6'-deoxychalcone, GU 17, GU-17, isoliquiritigenin
Formula	C₁₅H₁₂O₄
SMILES	C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O
InChI	1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
InChIKey	DXDRHHKMWQZJHT-FPYGCLRLSA-N
CAS Number	961-29-5
ChEMBL ID	CHEMBL129795
ChEBI ID	CHEBI:310312
Herb ID	HBIN030896
Drug Bank ID	DB03285
KEGG ID	C08650
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	GanCao
Use Part	Root, Rhizome
Habitat	HeiLongJiang, JiLin, LiaoNing, NeiMengGu, GanSu, XinJiang
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza uralensis

Chineses Pinyin	JiangXiang
Use Part	Dried Heartwood Of Tree Trunk And Root
Habitat	HaiNan, GuangDong, GuangXi, YunNan
Flavor	Pungent
Meridian Tropism	Liver, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Dalbergia 　　　　　　-->Species: Dalbergia odorifera

Chineses Pinyin	ZhiGanCao
Use Part	Root, Rhizome Of Prepared Liauorice Root
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, XinJiang, ShanDong
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza uralensis

Chineses Pinyin	CiHuaiHua
Use Part	Flower
Habitat	China
Flavor	Sweet
Meridian Tropism	Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Robinia 　　　　　　-->Species: Robinia pseudoacacia

Chineses Pinyin	DuHuiMaoDou
Use Part	Seed, Bark, Root, Leaf, Bean Screen, Branch
Habitat	FuJian, TaiWan, GuangDong, HaiNan, GuangXi, YunNan
Flavor	Mildly bitter
Meridian Tropism	Spleen, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Tephrosia 　　　　　　-->Species: Tephrosia purpurea

Chineses Pinyin	GuangGuoGanCao
Use Part	Root, Rhizome
Habitat	HeiLongJiang, JiLin, LiaoNing, BeiJing, TianJin, HeBei, ShanXi, NeiMengGu, Shaanxi, GanSu, QingHai, NingXia, XinJiang
Flavor	Sweet
Meridian Tropism	Heart, Lung, Spleen, Stomach

Chineses Pinyin	HongDouCao
Use Part	Whole Herb
Habitat	XinJiang
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Onobrychis 　　　　　　-->Species: Onobrychis viciifolia

Chineses Pinyin	HuCong
Use Part	Bulb
Habitat	ShanXi, HeNan, AnHui, HuBei, HuNan, JiangXi, ZheJiang, FuJian, GuangDong, GuiZhou, YunNan, HaiNan, XiZang, TaiWan
Flavor	Pungent
Meridian Tropism	Lung, Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Amaryllidaceae 　　　　　-->Genus: Allium 　　　　　　-->Species: Allium ascalonicum

Chineses Pinyin	HuiHuiDou
Use Part	Seed
Habitat	GanSu, QingHai, Shaanxi, ShanXi, HeBei
Flavor	Sweet
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Cicer 　　　　　　-->Species: Cicer arietinum

Chineses Pinyin	LingNanHuaiShu
Use Part	Seed, Root, Stem, Leaf
Habitat	YunNan, GuiZhou, GuangXi
Flavor	Bitter, Astringent
Meridian Tropism	Lung, Large intestine

Chineses Pinyin	LongXueShu
Use Part	Root
Habitat	GuangXi, YunNan, SiChuan, GuiZhou, XiZang, ChongQing
Flavor	Sweet, Salty
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Asparagales 　　　　-->Family: Asparagaceae 　　　　　-->Genus: Dracaena 　　　　　　-->Species: Dracaena cochinchinensis

Chineses Pinyin	YaMaiJiaYingTao
Use Part	Fruit, Root, Branch, Leaf, Core
Habitat	Sri Lanka , Indonesia

Chineses Pinyin	YunNanGanCao
Use Part	Root, Rhizome
Habitat	YunNan, XiZang
Flavor	Sweet, Pungent
Meridian Tropism	Heart, Spleen, Lung, Stomach
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza yunnanensis

Chineses Pinyin	ZhangGuoGanCao
Use Part	Root, Rhizome
Habitat	NeiMengGu, GanSu, XinJiang
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Fabales 　　　　-->Family: Fabaceae 　　　　　-->Genus: Glycyrrhiza 　　　　　　-->Species: Glycyrrhiza inflata

Pair Name	Isoliquiritigenin, Docosahexaenoic acid
Partner Name	Docosahexaenoic acid
Disease Info	[ICD-11: 2B91.Z]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->ROS generation
Gene Regulation	Up-regulation	Expression	FAS	hsa355
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Up-regulation	Expression	CYCS	hsa54205
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
Result	Excessive ROS-induced JNK activation and cytochrome c release from mitochondria played a key role in the synergistic anticancer activity of CRC cells by cotreating with DHA and ISL.

Pair Name	Isoliquiritigenin, TNF-related apoptosis inducing ligand
Partner Name	TNF-related apoptosis inducing ligand
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Biological Phenomena	Induction-->Apoptosis and autophagy
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
	Up-regulation	Expression	TNFRSF10B	hsa8795
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
Result	Isoliquiritigenin has the potential to overcome resistance to TRAIL in cancer cells and its chemopreventive effects may depend on TRAIL function

Pair Name	Isoliquiritigenin, Cyclophosphamide
Partner Name	Cyclophosphamide
Disease Info	[ICD-11: 2C77.Z]	Cervical cancer		Investigative
Biological Phenomena	Induction-->DNA damage
In Vitro Model	U14	Cervical carcinoma	Mus musculus (Mouse)	CVCL_9U56
In Vivo Model	KM mice were implanted subcutaneously with 0.2 mL (1×10⁷ mL in sodium chloride) U14 cells.
Result	Isoliquiritigen enhances the antitumour activity and decreases the genotoxic effect of cyclophosphamide

Pair Name	Isoliquiritigenin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Biological Phenomena	Induction-->DNA damage
In Vitro Model	CT26	Mouse colon adenocarcinoma	Mus musculus (Mouse)	CVCL_7254
In Vivo Model	The CT-26 mouse colon cancer cells (2×10⁶ cells in 0.1 mL PBS) cultured in DMEM with 10% FBS were subcutaneously injected into the right flanks of the BALB/c male mice.
Result	Supplementation with ISL may be an effective approach to counteracting the side effects of cisplatin therapy in cancer patients.