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3-O-acetyl-11-keto-boswellic acid, acetyl-11-keto-beta-boswellic acid, acetyl-11-keto-boswellic acid, acetyl-11-ketoboswellic acid, AcKBA, AKBA cpd

No.	Title	Href
1	Acetyl-11-keto-β-boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway. Cell Biol Toxicol. 2021 Apr;37(2):209-228. doi: 10.1007/s10565-020-09541-5.	`Click`

No.

Title

Href

Acetyl-11-keto-β-boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway. Cell Biol Toxicol. 2021 Apr;37(2):209-228. doi: 10.1007/s10565-020-09541-5.

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Name	AKBA
PubChem CID	11168203
Molecular Weight	512.7g/mol
Synonyms	3-O-acetyl-11-keto-boswellic acid, acetyl-11-keto-beta-boswellic acid, acetyl-11-keto-boswellic acid, acetyl-11-ketoboswellic acid, AcKBA, AKBA cpd
Formula	C₃₂H₄₈O₅
SMILES	CC1CCC2(CCC3(C(=CC(=O)C4C3(CCC5C4(CCC(C5(C)C(=O)O)OC(=O)C)C)C)C2C1C)C)C
InChI	1S/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32-/m1/s1
InChIKey	HMMGKOVEOFBCAU-BCDBGHSCSA-N
CAS Number	67416-61-9
ChEMBL ID	CHEMBL237111
ChEBI ID	CHEBI:166842
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	ChiYeRuXiang
Use Part	Resin exuded from stem bark
Flavor	Pungent; Bitter
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Sapindales 　　　　-->Family: Burseraceae 　　　　　-->Genus: Boswellia 　　　　　　-->Species: Boswellia serrata

Pair Name	AKBA, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Expression	ATG5	hsa9474
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	CCNA2	hsa890
	Down-regulation	Expression	CCNE1	hsa898
	Down-regulation	Phosphorylation	CDK1	hsa983
	Down-regulation	Expression	CDK4	hsa1019
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Expression	MAP1LC3A	hsa84557
	Down-regulation	Expression	MAP1LC3B	hsa81631
	Up-regulation	Expression	PSMD9	hsa5715
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
Result	Acetyl-11-keto-beta-boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway