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6-glucosyl-apigenin, 6-glucosylapigenin, apigenin 6-C-glucoside, isovitexin

No.	Title	Href
1	Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice. Int Immunopharmacol. 2021 May;94:107357. doi: 10.1016/j.intimp.2020.107357.	`Click`

No.

Title

Href

Isovitexin potentiated the antitumor activity of cisplatin by inhibiting the glucose metabolism of lung cancer cells and reduced cisplatin-induced immunotoxicity in mice. Int Immunopharmacol. 2021 May;94:107357. doi: 10.1016/j.intimp.2020.107357.

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Name	Isovitexin
PubChem CID	162350
Molecular Weight	432.4g/mol
Synonyms	6-glucosyl-apigenin, 6-glucosylapigenin, apigenin 6-C-glucoside, isovitexin
Formula	C₂₁H₂₀O₁₀
SMILES	C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)C4C(C(C(C(O4)CO)O)O)O)O)O
InChI	1S/C21H20O10/c22-7-14-17(26)19(28)20(29)21(31-14)16-11(25)6-13-15(18(16)27)10(24)5-12(30-13)8-1-3-9(23)4-2-8/h1-6,14,17,19-23,25-29H,7H2/t14-,17-,19+,20-,21+/m1/s1
InChIKey	MYXNWGACZJSMBT-VJXVFPJBSA-N
CAS Number	38953-85-4
ChEMBL ID	CHEMBL465360
ChEBI ID	CHEBI:18330
Herb ID	HBIN031346
KEGG ID	C01714
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	BanLanGen
Use Part	Root
Habitat	HeBei, JiangSu, AnHui
Flavor	Bitter
Meridian Tropism	Heart, Stomach

Chineses Pinyin	DaQingYe
Use Part	Leaf
Habitat	China
Flavor	Bitter
Meridian Tropism	Heart, Stomach

Chineses Pinyin	HuangGua
Use Part	Fruit
Habitat	China
Flavor	Sweet
Meridian Tropism	Lung, Spleen, Stomach

Chineses Pinyin	XiFanLian
Use Part	Whole herb
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Malpighiales 　　　　-->Family: Passifloraceae 　　　　　-->Genus: Passiflora 　　　　　　-->Species: Passiflora caerulea

Pair Name	Isovitexin, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	IL2	hsa3558
	Up-regulation	Expression	TNF	hsa7124
	Down-regulation	Expression	PKM	hsa5315
	Down-regulation	Phosphorylation	STAT3	hsa6774
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	BCL-xL	hsa598
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
In Vitro Model	NCI-H1975	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_1511
In Vivo Model	A549 cells at a concentration of 5 × 105 cells/25 μl were injected into left lung of each nude mouse.
Result	IVT not only inhibited cell proliferation and glucose metabolism via downregulating the expression of PKM2 to enhance the antitumor activity of DDP against lung cancer cells, and improved DDP-induced immunotoxicity in mice. It also presented a novel strategy to enhance the anti-tumor effect of platinum-based chemotherapy against NSCLC.