Pair Name | Flavokawain A, Herceptin | |||
Partner Name | Flavokawain A | |||
Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
Biological Phenomena | Induction-->Apoptosis | |||
Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
Up-regulation | Expression | BAX | hsa581 | |
Down-regulation | Expression | BCL2 | hsa596 | |
Up-regulation | Expression | BCL2L11 | KEGG ID N.A. | |
Down-regulation | Expression | BCL-xL | hsa598 | |
Up-regulation | Expression | BIM | hsa10018 | |
Down-regulation | Phosphorylation | CDC25C | hsa995 | |
Down-regulation | Phosphorylation | CDK1 | hsa983 | |
Down-regulation | Expression | ERBB2 | hsa2064 | |
Down-regulation | Expression | ERBB2 | hsa2064 | |
Down-regulation | Expression | MYT1 | hsa4661 | |
Down-regulation | Expression | SKP2 | hsa6502 | |
Down-regulation | Expression | WEE1 | hsa7465 | |
Down-regulation | Expression | XIAP | hsa331 | |
In Vitro Model | MCF-7 | Invasive breast carcinoma of no special type | Homo sapiens (Human) | CVCL_0031 |
MDA-MB-468 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0419 | |
Result | Our results suggest FKA as a promising and novel apoptosis inducer and G2 blocking agent that, in combination with Herceptin, enhances for the treatment of HER2-overexpressing breast cancer. |