Endostatin, N-methyl-N-phenacylnitrous amide, 187888-07-9, 55984-52-6, Endostatins, Ethanone, 2-(methylnitrosoamino)-1-phenyl-, 2-Oxo-2-phenylethylmethylnitrosamine, 2-[methyl(nitroso)amino]-1-phenylethanone, DTXSID10204557
| Name | Endostar | ||
| PubChem CID | 187888 | ||
| Molecular Weight | 178.19g/mol | ||
| Synonyms |
Endostatin, N-methyl-N-phenacylnitrous amide, 187888-07-9, 55984-52-6, Endostatins, Ethanone, 2-(methylnitrosoamino)-1-phenyl-, 2-Oxo-2-phenylethylmethylnitrosamine, 2-[methyl(nitroso)amino]-1-phenylethanone, DTXSID10204557 |
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| Drug Type | Small molecule | ||
| Formula | C₉H₁₀N₂O₂ | ||
| SMILES | CN(CC(=O)C1=CC=CC=C1)N=O | ||
| InChI | 1S/C9H10N2O2/c1-11(10-13)7-9(12)8-5-3-2-4-6-8/h2-6H,7H2,1H3 | ||
| InChIKey | AAFYOVPTFNNVDN-UHFFFAOYSA-N | ||
| CAS Number | 187888-07-9 | ||
| TTD ID | D05YAG | ||
| Drug Bank ID | DB06423 | ||
| Toxicity | Organism | Test Type | Route(Dose) |
| Structure | 
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2D
MOL
3D
MOL
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| Pair Name | Ginsenoside Rg3, Endostar | |||
| Partner Name | Ginsenoside Rg3 | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
| Down-regulation | Expression | BECN1 | hsa8678 | |
| Down-regulation | Expression | MAPK8 | hsa5599 | |
| Down-regulation | Expression | MMP2 | hsa4313 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| Down-regulation | Expression | MTOR | hsa2475 | |
| Down-regulation | Expression | PIK3CA | hsa5290 | |
| Down-regulation | Expression | SQSTM1 | hsa8878 | |
| Down-regulation | Expression | VEGFA | hsa7422 | |
| Down-regulation | Expression | VEGFB | hsa7423 | |
| Down-regulation | Expression | VEGFC | hsa7424 | |
| In Vivo Model | MCF-7 cells were inoculated under right mammary gland of female C57 mice. | |||
| Result | Endostar combined with ginsenoside Rg3 has stronger inhibiting effect on breast cancer tumor growth in tumor-bearing mice than single drug, and it can inhibit angiogenesis and cell invasion, and enhance cell autophagy. | |||
