2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)-ethyl)-phenol, 2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)ethyl)phenol, 3-hydro-4,3',4',5'-quamythloxy-stilbene, dihydrocombretastatin A-4(1c), Eri cpd, Erianin, isoerianin
| Name | Erianin | ||
| PubChem CID | 356759 | ||
| Molecular Weight | 318.4g/mol | ||
| Synonyms |
2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)-ethyl)-phenol, 2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)ethyl)phenol, 3-hydro-4,3',4',5'-quamythloxy-stilbene, dihydrocombretastatin A-4(1c), Eri cpd, Erianin, isoerianin |
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| Formula | C₁₈H₂₂O₅ | ||
| SMILES | COC1=C(C=C(C=C1)CCC2=CC(=C(C(=C2)OC)OC)OC)O | ||
| InChI | 1S/C18H22O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h7-11,19H,5-6H2,1-4H3 | ||
| InChIKey | UXDFUVFNIAJEGM-UHFFFAOYSA-N | ||
| CAS Number | 95041-90-0 | ||
| ChEMBL ID | CHEMBL10557 | ||
| Herb ID | HBIN025562 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | ShiHu | ||
| Use Part | Dendrobium loddigesii Rolfe.; Dendrobium fimbriatum Hook. var. oculatum Hook.; Dendrobium chrysanthum Wall.; Dendrobium candidum Wall. ex Lindl.; Dendrobium nobile Lindl. | ||
| Habitat | GuangXi, GuiZhou, YunNan, HuBei | ||
| Flavor | Sweet | ||
| Meridian Tropism | Stomach; Kidney | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Asparagales
-->Family: Orchidaceae
-->Genus: Dendrobium
-->Species: Dendrobium nobile
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| Pair Name | Erianin, Afatinib | |||
| Partner Name | Afatinib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Inhibition-->Angiogenesis | |||
| Gene Regulation | Down-regulation | Phosphorylation | FLT1 | hsa2321 |
| Down-regulation | Phosphorylation | KDR | hsa3791 | |
| Down-regulation | Expression | MMP2 | hsa4313 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| Down-regulation | Expression | PIK3CA | hsa5290 | |
| Down-regulation | Phosphorylation | SRC | hsa6714 | |
| Down-regulation | Phosphorylation | STAT3 | hsa6774 | |
| Down-regulation | Expression | VEGFA | hsa7422 | |
| In Vitro Model | Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 |
| In Vivo Model | 1×10⁷ HepG2 cells were resuspended in 50% matrigel solution (v/v, saline: matrigel = 1:1) and injected subcutaneously into the left forelimb of each mice. | |||
| Result | EBTP/Afa targets VEGF and EGFR signaling pathways in liver cancer cells and tumor vasculature, thereby inhibiting the proliferation, motion and angiogenesis of liver cancer cells. Overall, this study provides a new combined strategy for the clinical treatment of hepatocellular carcinoma. | |||
