Pair Name	Carvacrol, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	ABCB1	hsa5243
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	Our results suggest that carvacrol can downregulate P-gp expression and combination therapy with carvacrol and 5-FU is considered a novel approach to improve the efficacy of chemotherapeutics in cancer patients with high P-glycoprotein expression.

Pair Name	Carvacrol, Sorafenib
Partner Name	Sorafenib
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Down-regulation	Expression	ABCG2	hsa9429
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	CCND1	hsa595
	Up-regulation	Expression	GSS	hsa2937
	Down-regulation	Expression	HIF1A	hsa3091
	Up-regulation	Expression	IL6	hsa3569
	Down-regulation	Expression	LDHA	hsa3939
	Down-regulation	Expression	NOTCH1	hsa4851
	Down-regulation	Expression	SALL4	hsa57167
	Down-regulation	Expression	TGFB1	hsa7040
	Up-regulation	Expression	TNF	hsa7124
	Down-regulation	Expression	TRPM7	hsa54822
	Down-regulation	Expression	VEGFA	hsa7422
	Down-regulation	Expression	VIM	hsa7431
In Vivo Model	A preliminary study was conducted using 200 mg/kg of TAA dissolved in 0.2 mL of normal saline and given intraperitoneal (i.p.) twice a week for 16 weeks to induce HCC.
Result	CARV/Sora is a promising combination for tumor suppression and overcoming Sora resistance and cardiotoxicity in HCC by modulating TRPM7. To our best knowledge, this study represents the first study to investigate the efficiency of CARV/ Sora on the HCC rat model. Moreover, no previous studies have reported the effect of inhibiting TRPM7 on HCC.