1,7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione, tetrahydrocurcumin
| Name | Tetrahydrocurcumin | ||
| PubChem CID | 124072 | ||
| Molecular Weight | 372.4g/mol | ||
| Synonyms |
1,7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione, tetrahydrocurcumin |
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| Formula | C₂₁H₂₄O₆ | ||
| SMILES | COC1=C(C=CC(=C1)CCC(=O)CC(=O)CCC2=CC(=C(C=C2)O)OC)O | ||
| InChI | 1S/C21H24O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,24-25H,3-4,7-8,13H2,1-2H3 | ||
| InChIKey | LBTVHXHERHESKG-UHFFFAOYSA-N | ||
| CAS Number | 36062-04-1 | ||
| ChEMBL ID | CHEMBL318743 | ||
| ChEBI ID | CHEBI:67263 | ||
| Structure | 
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2D
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3D
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| Chineses Pinyin | GaoLiangJiang | ||
| Use Part | Rhizome | ||
| Habitat | HaiNan, GuangXi, YunNan, TaiWan, GuangDong | ||
| Flavor | Pungent | ||
| Meridian Tropism | Spleen, Stomach | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Alpinia
-->Species: Alpinia officinarum
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| Chineses Pinyin | JiangHuang | ||
| Use Part | Tuberoid | ||
| Habitat | SiChuan, FuJian, GuangDong, ZheJiang, JiangXi | ||
| Flavor | Pungent; Bitter | ||
| Meridian Tropism | Spleen; Liver | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Zingiberales
-->Family: Zingiberaceae
-->Genus: Curcuma
-->Species: Curcuma longa
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| Pair Name | Tetrahydrocurcumin, Celecoxib | |||
| Partner Name | Celecoxib | |||
| Disease Info | [ICD-11: 2C77.Z] | Cervical cancer | Investigative | |
| Biological Phenomena | Inhibition-->Angiogenesis | |||
| Gene Regulation | Down-regulation | Expression | VEGFA | hsa7422 |
| Down-regulation | Expression | MVD | hsa4597 | |
| Down-regulation | Expression | PTGS2 | hsa5743 | |
| Down-regulation | Expression | EGFR | hsa1956 | |
| In Vitro Model | Ca Ski | Human papillomavirus-related cervical squamous cell carcinoma | Homo sapiens (Human) | CVCL_1100 |
| In Vivo Model | To evaluate the combinational treatment effect of THC and celecoxib on tumor progression and tumor angiogenesis in cervical cancer (CaSki)-implanted nude mice. | |||
| Result | The combinational treatment effect of THC and celecoxib causing inhibition of tumor growth and tumor angiogenesis via down-regulation of VEGF, COX-2 and EGFR expression. However, this combined treatment did not show the synergistic effect on inhibiting the tumor growth and tumor angiogenesis in cervical cancer (CaSki)-implanted nude mice model. | |||
