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24-epibrassinolide, 2alpha,3alpha,22alpha,23alpha-tetrahydroxy-24alpha-methyl-B-homo-7-oxa-5alpha-cholestan-6-one, brassinolide, brassinolide, (2alpha,3alpha,5alpha,22S,23S)-isomer, brassinolide, (2alpha,3alpha,5alpha.22R,23R)-isomer

No.	Title	Href
1	The effect of brassinolide, a plant steroid hormone, on drug resistant small-cell lung carcinoma cells. Biochem Biophys Res Commun. 2017 Nov 4;493(1):783-787. doi: 10.1016/j.bbrc.2017.08.094.	`Click`

No.

Title

Href

The effect of brassinolide, a plant steroid hormone, on drug resistant small-cell lung carcinoma cells. Biochem Biophys Res Commun. 2017 Nov 4;493(1):783-787. doi: 10.1016/j.bbrc.2017.08.094.

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Name	Brassinolid
PubChem CID	115196
Molecular Weight	480.7g/mol
Synonyms	24-epibrassinolide, 2alpha,3alpha,22alpha,23alpha-tetrahydroxy-24alpha-methyl-B-homo-7-oxa-5alpha-cholestan-6-one, brassinolide, brassinolide, (2alpha,3alpha,5alpha,22S,23S)-isomer, brassinolide, (2alpha,3alpha,5alpha.22R,23R)-isomer
Formula	C₂₈H₄₈O₆
SMILES	CC(C)C(C)C(C(C(C)C1CCC2C1(CCC3C2COC(=O)C4C3(CC(C(C4)O)O)C)C)O)O
InChI	1S/C28H48O6/c1-14(2)15(3)24(31)25(32)16(4)18-7-8-19-17-13-34-26(33)21-11-22(29)23(30)12-28(21,6)20(17)9-10-27(18,19)5/h14-25,29-32H,7-13H2,1-6H3/t15-,16-,17-,18+,19-,20-,21+,22-,23+,24+,25+,27+,28+/m0/s1
InChIKey	IXVMHGVQKLDRKH-KNBKMWSGSA-N
CAS Number	72962-43-7
ChEBI ID	CHEBI:28277
KEGG ID	C08814
Structure		Download 2D MOL 3D MOL

Chineses Pinyin	YouCai
Use Part	Seed
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Brassicales 　　　　-->Family: Brassicaceae 　　　　　-->Genus: Brassica 　　　　　　-->Species: Brassica rapa subsp/ oleifera

Pair Name	Brassinolid, Doxorubicin
Partner Name	Doxorubicin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	APC	hsa324
	Down-regulation	Expression	BIRC5	hsa332
	Up-regulation	Activity	CASP3	hsa836
	Down-regulation	Expression	JUN	hsa3725
	Down-regulation	Expression	MMP1	hsa4312
	Down-regulation	Expression	MMP26	hsa56547
	Down-regulation	Expression	MMP7	hsa4316
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Expression	NANOG	hsa79923
	Up-regulation	Expression	POU5F1	hsa5460
	Down-regulation	Expression	SOX9	hsa6662
	Up-regulation	Expression	VEGFA	hsa7422
In Vitro Model	NCI-H69	Lung small cell carcinoma	Homo sapiens (Human)	CVCL_1579
Result	These data indicate that EB, a natural product with widespread occurrence in plants, is pharmacologically active in both drug-sensitive and drug-resistant SCLC cells and acts through the Wnt signaling pathway.